Isosorbide

Product Name: Isosorbide
CAS No.: 652-67-5
Chemical Name: Isosorbide
Synonyms: (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol;at101;IsMotic;Isosorbide (75% solution, 1 g);ucitoL;isobide;hydronol;Isosorbid;NSC 40725;devicoran
CBNumber: CB1162705
Molecular Formula: C6H10O4
Formula Weight: 146.14
MOL File: 652-67-5.mol

More

Less

Isosorbide Property

Melting point:: 60-63 °C (lit.)
alpha: 42 º (c=3, H2O)
Boiling point:: 175°C/2mmHg(lit.)
Density: 1.0945 (rough estimate)
vapor pressure: 0.007Pa at 20℃
refractive index: 45 ° (C=5, H2O)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Crystals, Crystalline Solid or Mass
pka: 13.17±0.40(Predicted)
color: Off-white to light yellow or beige
optical activity: [α]20/D +45.2°, c = 3 in H2O
Water Solubility: Soluble in alcohols, water and ketones.
Sensitive: Hygroscopic
Merck: 14,5224
BRN: 80510
Cosmetics Ingredients Functions: SKIN CONDITIONING
HUMECTANT
InChI: 1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey: KLDXJTOLSGUMSJ-JGWLITMVSA-N
SMILES: O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12
LogP: -1.39 at 20℃
CAS DataBase Reference: 652-67-5(CAS DataBase Reference)
EPA Substance Registry System: D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)

More

Less

Safety

Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 2
RTECS: LZ4380000
TSCA: TSCA listed
HS Code: 29349990
Storage Class: 11 - Combustible Solids
Hazardous Substances Data: 652-67-5(Hazardous Substances Data)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 329207
Product name: Dianhydro-D-glucitol
Purity: 98%
Packaging: 100g
Price: $94.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1352008
Product name: Isosorbide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 1g
Price: $467
Updated: 2025/07/31

TCI Chemical

Product number: I0407
Product name: Isosorbide
Purity: >98.0%(GC)
Packaging: 25g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: I0407
Product name: Isosorbide
Purity: >98.0%(GC)
Packaging: 100g
Price: $54
Updated: 2025/07/31

Sigma-Aldrich

Product number: 329207
Product name: Dianhydro-D-glucitol
Purity: 98%
Packaging: 500g
Price: $262
Updated: 2025/07/31

More

Less

Isosorbide Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow or beige crystals,

Uses

pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.

Uses

D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.

Uses

Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.

Definition

A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.

brand name

Ismotic (Alcon).

Biological Functions

emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.

Flammability and Explosibility

Non flammable

Clinical Use

Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

Synthesis

Isosorbide can be obtained by catalytic dehydration of sorbitol, sorbitol can be converted from starch, sucrose, glucose and other renewable resources, and has long been large-scale industrialized production, process maturity, cheap.

Isosorbide Preparation Products And Raw materials

Raw materials

D-Sorbitol Sorbitol

Preparation Products

More

Less

Isosorbide Suppliers

Americas 1 Belgium 4 Canada 2 China 397 Europe 4 Germany 11 India 18 Japan 4 Malaysia 1 Singapore 2 Slovakia 1 South Korea 1 Spain 2 Switzerland 6 The Netherlands 2 Ukraine 1 United Kingdom 12 United States 35 Global 504

Puyang Shengtong Juyuan New Materials Co.,Ltd.

Tel: 03935331669 15839333421
Email: china_wulin@foxmail.com
Country: China
ProdList: 17
Advantage: 58

Shanghai Xinyue Chemical Co., Ltd.

Tel: 18116267768
Fax: 021-51685846
Email: 645908973@qq.com
Country: China
ProdList: 112
Advantage: 58

Jinan Hongbaifeng Industry And Trade Co., Ltd

Tel: 0531-87333789 15066110813
Email: hongbaifeng@live.cn
Country: China
ProdList: 2
Advantage: 58

Shandong Kangman Biological Technology Co., Ltd.

Tel: 0539-7109900 18253952333
Fax: +86-539-7109969
Email: sales2@cmpharm.com.cn
Country: China
ProdList: 264
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8772
Advantage: 58

Yantai Shunkang Biotechnology Co., Ltd.

Tel: 0535-7876627 13370911691
Fax: 0535-7876601
Email: ben@sikonbio.net
Country: China
ProdList: 150
Advantage: 58

Shandong Lifan Chemical Co. LTD

Tel: 17864861555
Email: 896889070@qq.com
Country: China
ProdList: 99
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

More

Less

View Lastest Price from Isosorbide manufacturers

Puyang Shengtong Juyuan New Materials Co., Ltd.

Product: Isosorbide 652-67-5
Price: US $8000.00/KG
Min. Order: 1000KG
Purity: ≥99.5%
Supply Ability: 250MT/month
Release date: 2026-01-30

Wuhan JiyunZen Tech Co., Ltd.

Product: Isosorbide 652-67-5
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: Isosorbide 652-67-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-05

652-67-5, IsosorbideRelated Search:

Isosorbide dinitrate D(+)-Glucose Isosorbide dimethyl ether Ammonium carbonate Isosorbide-2-Acetate ISOSORBIDE MONONITRATE,ISOSORBIDE 5-NITRATE,ISOSORBIDE 5-MONONITRATE, 98.5%,ISOSORBIDE MONO ACETATE,ISOSORBIDE 5-MONONITRATE,5-ISOSORBIDE MONONITRATE ISOSORBIDE 2-MONONITRATE,ISOSORBIDE 2-MONONITRATE 99-101.0%,isosorbide2-nitrat Isostearic Acid isononyl alcohol 1,4-ANHYDRO-D-GLUCITOL Octadecyl isocyanate 3-Methyl-1-butanol Sorbitol Isosorbide-13C6 2-Mononitrate,Isosorbide-13C6 2-Nitrate 2-CHLOROETHYL ISOTHIOCYANATE ISOCYANIC ACID FIXATEUR ITC Potassium 2-ethylhexanoate

Dianhydro-D-glucitol 98%

1,4:3,6-DIANHYDRO-D-SORBITOL

1,4:3,6-DIANHYDROGLUCITOL

1,4:3,6-DIANHYDROSORBITOL

1,4:3,6-DIANHYDRO-D-GLUCITOL

D-ISOSORBIDE

DIANHYDRO-D-GLUCITOL

DIANHYDRO-D-SORBITOL

ISOSORBIDE

(3S,3AR,6R,6AR)-HEXAHYDRO-FURO[3,2-B]FURAN-3,6-DIOL

1,4:3,6-dianhydro-d-glucito

Isosorbide, typically 98%

1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide

Isosorbide,98%

Dianhydro-D-glucitol,1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide

Isosorbide (75% solution, 1 g)

Isosorbide, 98% 100GR

IsMotic

1,4:3,6-Dianhydroglucitol 1,4:3,6-Dianhydrosorbitol

(3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol

1,4,3,6,5-Dianhydrosorbitol

ISOSONBIDE(1,4:3,6-DIANHYDRO-D-SORHITOL)

Isosorbid

D-Glucitol, 1,4:3,6-dianhydro-

D-Glucitol, 1,4:3,6-dianhydro- (9CI)

NSC 40725

1,4,3,6-DIANHYDRO-D-GLUCITOL D-ISOSORBIDE

4:3,6-dianhydro-d-glucito

at101

d-1,4:3,6-dianhydroglucitol

devicoran

hydronol

isobide

Isosorbide,typically98%

Isosorbide Isosorbide

Isosorbide&gt

Isosorbide, 97%, reagent grade

Dianhydro-D-g

ucitoL

Dianhydro-D-gL

Isosorbide USP/EP/BP

Isosorbide Impurity 21

Isosorbide Impurity 22

IsosorbideQ: What is Isosorbide Q: What is the CAS Number of Isosorbide Q: What is the storage condition of Isosorbide Q: What are the applications of Isosorbide

Isosorbide (75% solution, 1 g) (1352008)

1,4：3,6-dianhydro-D-[UL-13C6]glucitol

Isosorbitol

(3S, 3AR, 6R, 6AR) - Hexahydrogen - [3,2-B] furan-3,6-diol)

Isosorbide 1,4:3,6-Dianhydro-D-glucitol

Isosorbide in Acetonitrile

lsosorbide

Isosorbide, 10 mM in DMSO

Dianhydro-<sc>D</sc>-glucitol

652-67-5

662-67-5

652-67-8

Carbohydrate Synthesis

Specialty Synthesis