ChemicalBook > CAS DataBase List > Isosorbide

Isosorbide

Product Name
Isosorbide
CAS No.
652-67-5
Chemical Name
Isosorbide
Synonyms
(3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol;at101;IsMotic;Isosorbide (75% solution, 1 g);ucitoL;isobide;hydronol;Isosorbid;NSC 40725;devicoran
CBNumber
CB1162705
Molecular Formula
C6H10O4
Formula Weight
146.14
MOL File
652-67-5.mol
More
Less

Isosorbide Property

Melting point:
60-63 °C (lit.)
alpha 
42 º (c=3, H2O)
Boiling point:
175°C/2mmHg(lit.)
Density 
1.0945 (rough estimate)
vapor pressure 
0.007Pa at 20℃
refractive index 
45 ° (C=5, H2O)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Crystals, Crystalline Solid or Mass
pka
13.17±0.40(Predicted)
color 
Off-white to light yellow or beige
optical activity
[α]20/D +45.2°, c = 3 in H2O
Water Solubility 
Soluble in alcohols, water and ketones.
Sensitive 
Hygroscopic
Merck 
14,5224
BRN 
80510
InChIKey
KLDXJTOLSGUMSJ-JGWLITMVSA-N
LogP
-1.39 at 20℃
CAS DataBase Reference
652-67-5(CAS DataBase Reference)
EPA Substance Registry System
D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)
More
Less

Safety

Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
2
RTECS 
LZ4380000
TSCA 
Yes
HS Code 
29349990
Hazardous Substances Data
652-67-5(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
329207
Product name
Dianhydro-D-glucitol
Purity
98%
Packaging
100g
Price
$91.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1352008
Product name
Isosorbide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1g
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
I0407
Product name
Isosorbide
Purity
>98.0%(GC)
Packaging
25g
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
I0407
Product name
Isosorbide
Purity
>98.0%(GC)
Packaging
100g
Price
$54
Updated
2024/03/01
Alfa Aesar
Product number
A13989
Product name
D-Isosorbide, 98%
Packaging
50g
Price
$39.3
Updated
2024/03/01
More
Less

Isosorbide Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow or beige crystals,

Uses

pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.

Uses

D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.

Uses

Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.

Definition

A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.

brand name

Ismotic (Alcon).

Biological Functions

emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.

Flammability and Explosibility

Non flammable

Clinical Use

Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

Isosorbide Preparation Products And Raw materials

Raw materials

D-Sorbitol Sorbitol

Preparation Products

More
Less

Isosorbide Suppliers

Americas 1 Belgium 4 Canada 2 China 345 Europe 4 Germany 11 India 18 Japan 4 Malaysia 1 Singapore 2 Slovakia 1 South Korea 1 Spain 2 Switzerland 6 The Netherlands 2 Ukraine 1 United Kingdom 12 United States 35 Global 452
Jinan Hongbaifeng Industry And Trade Co., Ltd.
Tel
86-531-87333789 15066110813
Fax
86-531-87333868
Email
hongbaifeng@live.cn
Country
China
ProdList
2
Advantage
58
Yantai Shunkang Biotechnology Co., Ltd.
Tel
0535-7876627 13370911691
Fax
0535-7876601
Email
shunkang@ytsk.com.cn
Country
China
ProdList
173
Advantage
58
Shandong Kangman Biological Technology Co., Ltd.
Tel
0539-7109900 18253952333
Fax
+86-539-7109969
Email
sales2@cmpharm.com.cn
Country
China
ProdList
264
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
0573-86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8025
Advantage
58
Hubei Baidu Chemical Co., Ltd
Tel
027-59106051 13627137652
Fax
027-59223020
Email
1438180055@qq.com
Country
China
ProdList
9965
Advantage
58
Jinan Hongbaifeng Industry And Trade Co., Ltd
Tel
0531-87333789 15066110813
Email
hongbaifeng@live.cn
Country
China
ProdList
2
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2963
Advantage
65
Zhangjiagang BoMan Chemical Co., Ltd.
Tel
15601563028
Fax
4006648400-2
Country
China
ProdList
29
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Simagchem Corp.
Tel
86 592 2680277
Fax
0086 592 2680237
Email
sale@simagchem.com
Country
China
ProdList
430
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2546
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2666
Advantage
55
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Ningbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.
Tel
+86 (574) 8111-0986
Fax
+86 (574) 5687-7575
Email
inquiry@nicesynth-chem.com
Country
China
ProdList
87
Advantage
58
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
More
Less

View Lastest Price from Isosorbide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Isosorbide 652-67-5
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10ton
Release date
2024-05-22
Baoji Guokang Bio-Technology Co., Ltd.
Product
Isosorbide 652-67-5
Price
US $14.50/KG
Min. Order
25KG
Purity
98%
Supply Ability
1-200mt
Release date
2021-06-03
Hebei Weibang Biotechnology Co., Ltd
Product
Isosorbide 652-67-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-05

652-67-5, IsosorbideRelated Search:

Sorbitol Isosorbide dinitrate D(+)-Glucose Isosorbide dimethyl ether Ammonium carbonate Isosorbide-2-Acetate ISOSORBIDE MONONITRATE,ISOSORBIDE 5-NITRATE,ISOSORBIDE 5-MONONITRATE, 98.5%,ISOSORBIDE MONO ACETATE,ISOSORBIDE 5-MONONITRATE,5-ISOSORBIDE MONONITRATE ISOSORBIDE 2-MONONITRATE,ISOSORBIDE 2-MONONITRATE 99-101.0%,isosorbide2-nitrat Isostearic Acid isononyl alcohol 1,4-ANHYDRO-D-GLUCITOL Octadecyl isocyanate 3-Methyl-1-butanol Isosorbide-13C6 2-Mononitrate,Isosorbide-13C6 2-Nitrate 2-CHLOROETHYL ISOTHIOCYANATE ISOCYANIC ACID FIXATEUR ITC Potassium 2-ethylhexanoate

  • Dianhydro-D-glucitol 98%
  • 1,4:3,6-DIANHYDRO-D-SORBITOL
  • 1,4:3,6-DIANHYDROGLUCITOL
  • 1,4:3,6-DIANHYDROSORBITOL
  • 1,4:3,6-DIANHYDRO-D-GLUCITOL
  • D-ISOSORBIDE
  • DIANHYDRO-D-GLUCITOL
  • DIANHYDRO-D-SORBITOL
  • ISOSORBIDE
  • (3S,3AR,6R,6AR)-HEXAHYDRO-FURO[3,2-B]FURAN-3,6-DIOL
  • 1,4:3,6-dianhydro-d-glucito
  • Isosorbide, typically 98%
  • 1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide
  • Isosorbide,98%
  • Dianhydro-D-glucitol,1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide
  • Isosorbide (75% solution, 1 g)
  • Isosorbide, 98% 100GR
  • IsMotic
  • 1,4:3,6-Dianhydroglucitol 1,4:3,6-Dianhydrosorbitol
  • (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol
  • 1,4,3,6,5-Dianhydrosorbitol
  • ISOSONBIDE(1,4:3,6-DIANHYDRO-D-SORHITOL)
  • Isosorbid
  • D-Glucitol, 1,4:3,6-dianhydro-
  • D-Glucitol, 1,4:3,6-dianhydro- (9CI)
  • NSC 40725
  • 1,4,3,6-DIANHYDRO-D-GLUCITOL D-ISOSORBIDE
  • 4:3,6-dianhydro-d-glucito
  • at101
  • d-1,4:3,6-dianhydroglucitol
  • devicoran
  • hydronol
  • isobide
  • Isosorbide,typically98%
  • Isosorbide Isosorbide
  • Isosorbide&gt
  • Isosorbide, 97%, reagent grade
  • Dianhydro-D-g
  • ucitoL
  • Dianhydro-D-gL
  • Isosorbide USP/EP/BP
  • Isosorbide Impurity 21
  • Isosorbide Impurity 22
  • IsosorbideQ: What is Isosorbide Q: What is the CAS Number of Isosorbide Q: What is the storage condition of Isosorbide Q: What are the applications of Isosorbide
  • Isosorbide (75% solution, 1 g) (1352008)
  • 1,4：3,6-dianhydro-D-[UL-13C6]glucitol
  • Isosorbitol
  • (3S, 3AR, 6R, 6AR) - Hexahydrogen - [3,2-B] furan-3,6-diol)
  • Isosorbide 1,4:3,6-Dianhydro-D-glucitol
  • Isosorbide in Acetonitrile
  • lsosorbide
  • 652-67-5
  • 662-67-5
  • Carbohydrate Synthesis
  • Specialty Synthesis
  • Monosaccharides
  • Carbohydrates & Derivatives
  • Heterocycles