Isosorbide dinitrate
- Product Name
- Isosorbide dinitrate
- CAS No.
- 87-33-2
- Chemical Name
- Isosorbide dinitrate
- Synonyms
- ISDN;isordil;sorbide;carvasin;sorbitrate;Lion's Mane;dilatrate-sr;Isosorbide dinitrate CRS;(3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate;cardis
- CBNumber
- CB2226929
- Molecular Formula
- C6H8N2O8
- Formula Weight
- 236.14
- MOL File
- 87-33-2.mol
Isosorbide dinitrate Property
- Melting point:
- 700C
- alpha
- D20 +135° (alc)
- Boiling point:
- 378.59°C (rough estimate)
- Density
- 1.7503 (rough estimate)
- refractive index
- 1.5010 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Undiluted isosorbide dinitrate is very slightly soluble in water, very soluble in acetone, sparingly soluble in ethanol (96 per cent). The solubility of the diluted product depends on the diluent and its concentration.
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 549.7mg/L(25 ºC)
- BCS Class
- 3
- InChIKey
- MOYKHGMNXAOIAT-JGWLITMVSA-N
- LogP
- 1.31 at 25℃
- CAS DataBase Reference
- 87-33-2(CAS DataBase Reference)
- EPA Substance Registry System
- D-Glucitol, 1,4:3,6-dianhydro-, dinitrate (87-33-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 5-22
- Safety Statements
- 36
- RIDADR
- UN 2907
- HazardClass
- 4.1
- PackingGroup
- II
- HS Code
- 2932999000
- Hazardous Substances Data
- 87-33-2(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 747mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P230Keep wetted with …
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P380+P375in case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23990
- Product name
- Isosorbide Dinitrate
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23990
- Product name
- Isosorbide Dinitrate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 23990
- Product name
- Isosorbide Dinitrate
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 23990
- Product name
- Isosorbide Dinitrate
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 293783
- Product name
- Isosorbide dinitrate
- Packaging
- 10mg
- Price
- $340
- Updated
- 2021/12/16
Isosorbide dinitrate Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Originator
Isordil,Ives,US,1959
Uses
Coronary vasodilator
Uses
Isosorbide dinitrate is also used in chronic cardiac insufficiency for preventing angina pectoris attacks. It is a long-lasting drug.
Uses
Antianginal;Nitric oxide (NO) donor
Definition
ChEBI: Isosorbide dinitrate is a nitrate ester and a glucitol derivative. It has a role as a vasodilator agent and a nitric oxide donor.
Manufacturing Process
An aqueous syrup of 1,4:3,6-dianhydro-D-glucitol is slowly added to a cooled mixture of HNO3 and H2SO4. After standing a few minutes the mixture is poured into cold water and the precipitated product is collected and recrystallized from ethanol.
brand name
Dilatrate (Schwarz Pharma); Isordil (Biovail); Isordil (Wyeth); Sorbitrate (AstraZeneca).
Therapeutic Function
Coronary vasodilator
General Description
A crystalline solid. May be toxic by ingestion. Used to make pharmaceuticals. Used as a heart drug.
Air & Water Reactions
Highly flammable. Slightly soluble in water.
Reactivity Profile
Nitroalkanes, such as Isosorbide dinitrate, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. This heart drug is detonable when dry, but non-explosive with 30% of water.
Health Hazard
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Clinical Use
Vasodilator:
Prophylaxis and treatment of angina
Left ventricular failure
Safety Profile
Moderately toxic by ingestion, intraperitoneal, intramuscular, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits toxic fumes of NOx. A coronary vasodilator. See also NITRATES.
Synthesis
Isosorbiddinitrate, 1,4:3,6-dianhydrosorbate-2,5-dinitrate (19.1.4), is synthesized by intermolecular dehydration of D-sorbite into isosorbide (19.1.3) using paratoluenesulfonic acid and subsequent nitration of the two hydroxyl groups by nitric acid.
Veterinary Drugs and Treatments
Isosorbide mononitrate (ISMN) and dinitrate (ISDN) are organic
nitrates potentially useful as preload reducing agents in treating
heart failure in small animals, however, research and clinical experience
demonstrating clinical efficacy are lacking in dogs or cats.
Limited research indicates that dogs may require much higher dosages
of isosorbide dinitrate to achieve therapeutic effects than do
humans.
In humans, isosorbide nitrates are used for treating or preventing
angina, treating esophageal spasm, and as an adjunctive treatment
in CHF.
Isosorbide dinitrate Preparation Products And Raw materials
Raw materials
Preparation Products
Isosorbide dinitrate Suppliers
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View Lastest Price from Isosorbide dinitrate manufacturers
- Product
- Isosorbide dinitrate dinitrate 40% 87-33-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 38%～42%,EP10
- Supply Ability
- 100kg/month
- Release date
- 2021-06-19
- Product
- isosorbide dinitrate 87-33-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07
- Product
- Isosorbide Dinitrate 87-33-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20