Isosorbide-2-Acetate

Product Name: Isosorbide-2-Acetate
CAS No.: 13042-39-2
Chemical Name: Isosorbide-2-Acetate
Synonyms: 2-Acetyl-isosorbide;Isosorbide Impurity 5;Isosorbide Impurity 15;Isosorbide Dinitrate Impurity 5;1,4:3,6-dianhydro-D-glucitol 2-acetate;1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol;D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate;(3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate;(6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate;(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate
CBNumber: CB7874929
Molecular Formula: C8H12O5
Formula Weight: 188.18
MOL File: 13042-39-2.mol

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Isosorbide-2-Acetate Property

Melting point:: 78 °C
Boiling point:: 323.0±42.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
pka: 13.35±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 293150
Product name: 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging: 10g
Price: $359
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MD09909
Product name: 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging: 100g
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077644
Product name: ISOSORBIDE-2-ACETATE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MD09909
Product name: 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging: 5G
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MD09909
Product name: 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging: 10g
Price: $80
Updated: 2021/12/16

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Isosorbide-2-Acetate Chemical Properties,Usage,Production

Chemical Properties

Isosorbide-2-acetate is a colourless, crystalline substance with a melting point of 75°-76°C. It has a TLC (diethyl ether) value of Rf=0.28 and a specific rotation of [α]D 20 =+77.1° (c=1.12, ethyl acetate). It is an important intermediate in the synthesis of isosorbide-5-mononitrate, a well-known organic nitrate drug.

Uses

1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol is a useful reagent in the practical enzymic synthesis of isosorbide-2-acetate.

Preparation

The synthesis of isosorbide-2-acetate involves dissolving 2.30 g (10 mmol) of isosorbide-2,5-diacetate in 15 ml of acetone and 5 ml of n-heptanol. Then, 200 mg of lipase from Pseudomonas fluorescens (SAM II, Amano Pharmaceuticals) is added, and the mixture is stirred at room temperature for 2 days. After that, the enzyme is removed by filtration, and the resulting solid is washed thoroughly with acetone. The solvent, excess n-heptanol, and heptyl acetate residue are removed by distillation.
The yield is 1.71 g (9.09 mmol) of isosorbide-2-acetate, which is a colourless crystalline substance with a melting point of 75°-76°C. The overall yield is 91%.
US5538891A

Isosorbide-2-Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Isosorbide-2-Acetate Suppliers

China 52 Germany 2 India 2 United Kingdom 2 United States 3 Global 61

Connect Chemicals GmbH

Tel: +49 2102 2077 19
Fax: +49 2102 2077 40
Email: Martin.Klapper@connectchemicals.com
Country: Germany
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ChemStrong Scientific Co.,Ltd

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Fax: 0755-28363542
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Country: China
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Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5881
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Amadis Chemical Company Limited

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Wuxi AppTec

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Shanghai Zhen Li Biological Technology Co., Ltd

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Aikon International Limited

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Wuhan FengyaoTonghui Chemical Products Co., Ltd.

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TOSUN PHARM

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Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 6710
Advantage: 58

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View Lastest Price from Isosorbide-2-Acetate manufacturers

Jiangsu Nata Opto-electronic Material Co.,Ltd.

Product: Isosorbide-2-Acetate 13042-39-2
Price: US $0.00/g
Min. Order: 50g
Purity: 98%
Supply Ability: 5kg
Release date: 2023-05-24

13042-39-2, Isosorbide-2-AcetateRelated Search:

POLY(VINYL ACETATE) Glatiramer acetate Triacetin Potassium Acetate Isosorbide 1-Methoxy-2-propyl acetate Furan Tocopherol Ethyl acetate Ethylene glycol monoethyl ether acetate Dimethylbenzylcarbinyl acetate Butyl acetate Tween 80 D-alpha-Tocopheryl acetate 2-Butoxyethyl acetate PHENYL ACETATE Tocopheryl acetate Sodium acetate

1,4:3,6-dianhydro-D-glucitol 2-acetate

(6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate

Acetic acid (3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl ester

(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate

(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) ethanoate

acetic acid (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) ester

2-Acetyl-isosorbide

1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol

(3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate

Isosorbide Impurity 5

D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate

Isosorbide Impurity 15

Isosorbide Dinitrate Impurity 5

13042-39-2