ChemicalBook > CAS DataBase List > Isosorbide-2-Acetate

Isosorbide-2-Acetate

Product Name
Isosorbide-2-Acetate
CAS No.
13042-39-2
Chemical Name
Isosorbide-2-Acetate
Synonyms
2-Acetyl-isosorbide;Isosorbide Impurity 5;Isosorbide Impurity 15;Isosorbide Dinitrate Impurity 5;1,4:3,6-dianhydro-D-glucitol 2-acetate;1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol;D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate;(3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate;(6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate;(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate
CBNumber
CB7874929
Molecular Formula
C8H12O5
Formula Weight
188.18
MOL File
13042-39-2.mol
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Isosorbide-2-Acetate Property

Melting point:
78 °C
Boiling point:
323.0±42.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
pka
13.35±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological
Product number
293150
Product name
1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging
10g
Price
$359
Updated
2021/12/16
Biosynth Carbosynth
Product number
MD09909
Product name
1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging
100g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077644
Product name
ISOSORBIDE-2-ACETATE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
Biosynth Carbosynth
Product number
MD09909
Product name
1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging
5G
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
MD09909
Product name
1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
Packaging
10g
Price
$80
Updated
2021/12/16
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Isosorbide-2-Acetate Chemical Properties,Usage,Production

Chemical Properties

Isosorbide-2-acetate is a colourless, crystalline substance with a melting point of 75°-76°C. It has a TLC (diethyl ether) value of Rf=0.28 and a specific rotation of [α]D 20 =+77.1° (c=1.12, ethyl acetate). It is an important intermediate in the synthesis of isosorbide-5-mononitrate, a well-known organic nitrate drug.

Uses

1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol is a useful reagent in the practical enzymic synthesis of isosorbide-2-acetate.

Preparation

The synthesis of isosorbide-2-acetate involves dissolving 2.30 g (10 mmol) of isosorbide-2,5-diacetate in 15 ml of acetone and 5 ml of n-heptanol. Then, 200 mg of lipase from Pseudomonas fluorescens (SAM II, Amano Pharmaceuticals) is added, and the mixture is stirred at room temperature for 2 days. After that, the enzyme is removed by filtration, and the resulting solid is washed thoroughly with acetone. The solvent, excess n-heptanol, and heptyl acetate residue are removed by distillation.
The yield is 1.71 g (9.09 mmol) of isosorbide-2-acetate, which is a colourless crystalline substance with a melting point of 75°-76°C. The overall yield is 91%.
US5538891A

Isosorbide-2-Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isosorbide-2-Acetate manufacturers

Jiangsu Nata Opto-electronic Material Co.,Ltd.
Product
Isosorbide-2-Acetate 13042-39-2
Price
US $0.00/g
Min. Order
50g
Purity
98%
Supply Ability
5kg
Release date
2023-05-24

13042-39-2, Isosorbide-2-AcetateRelated Search:

POLY(VINYL ACETATE) Glatiramer acetate Triacetin Potassium Acetate Isosorbide 1-Methoxy-2-propyl acetate Furan Tocopherol Ethyl acetate Ethylene glycol monoethyl ether acetate Dimethylbenzylcarbinyl acetate Butyl acetate Tween 80 D-alpha-Tocopheryl acetate 2-Butoxyethyl acetate PHENYL ACETATE Tocopheryl acetate Sodium acetate

  • 1,4:3,6-dianhydro-D-glucitol 2-acetate
  • (6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate
  • Acetic acid (3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl ester
  • (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate
  • (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) ethanoate
  • acetic acid (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) ester
  • 2-Acetyl-isosorbide
  • 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
  • (3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate
  • Isosorbide Impurity 5
  • D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate
  • Isosorbide Impurity 15
  • Isosorbide Dinitrate Impurity 5
  • 13042-39-2