Isosorbide-2-Acetate
- Product Name
- Isosorbide-2-Acetate
- CAS No.
- 13042-39-2
- Chemical Name
- Isosorbide-2-Acetate
- Synonyms
- 2-Acetyl-isosorbide;Isosorbide Impurity 5;Isosorbide Impurity 15;Isosorbide Dinitrate Impurity 5;1,4:3,6-dianhydro-D-glucitol 2-acetate;1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol;D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate;(3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate;(6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate;(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate
- CBNumber
- CB7874929
- Molecular Formula
- C8H12O5
- Formula Weight
- 188.18
- MOL File
- 13042-39-2.mol
Isosorbide-2-Acetate Property
- Melting point:
- 78 °C
- Boiling point:
- 323.0±42.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- pka
- 13.35±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 293150
- Product name
- 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
- Packaging
- 10g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- MD09909
- Product name
- 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
- Packaging
- 100g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CHM0077644
- Product name
- ISOSORBIDE-2-ACETATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- MD09909
- Product name
- 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
- Product number
- MD09909
- Product name
- 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol
- Packaging
- 10g
- Price
- $80
- Updated
- 2021/12/16
Isosorbide-2-Acetate Chemical Properties,Usage,Production
Chemical Properties
Isosorbide-2-acetate is a colourless, crystalline substance with a melting point of 75°-76°C. It has a TLC (diethyl ether) value of Rf=0.28 and a specific rotation of [α]D 20 =+77.1° (c=1.12, ethyl acetate). It is an important intermediate in the synthesis of isosorbide-5-mononitrate, a well-known organic nitrate drug.
Uses
1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol is a useful reagent in the practical enzymic synthesis of isosorbide-2-acetate.
Preparation
The synthesis of isosorbide-2-acetate involves dissolving 2.30 g (10 mmol) of isosorbide-2,5-diacetate in 15 ml of acetone and 5 ml of n-heptanol. Then, 200 mg of lipase from Pseudomonas fluorescens (SAM II, Amano Pharmaceuticals) is added, and the mixture is stirred at room temperature for 2 days. After that, the enzyme is removed by filtration, and the resulting solid is washed thoroughly with acetone. The solvent, excess n-heptanol, and heptyl acetate residue are removed by distillation.
The yield is 1.71 g (9.09 mmol) of isosorbide-2-acetate, which is a colourless crystalline substance with a melting point of 75°-76°C. The overall yield is 91%.
US5538891A
Isosorbide-2-Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Isosorbide-2-Acetate Suppliers
- Tel
- +49 2102 2077 19
- Fax
- +49 2102 2077 40
- Martin.Klapper@connectchemicals.com
- Country
- Germany
- ProdList
- 404
- Advantage
- 62
View Lastest Price from Isosorbide-2-Acetate manufacturers
- Product
- Isosorbide-2-Acetate 13042-39-2
- Price
- US $0.00/g
- Min. Order
- 50g
- Purity
- 98%
- Supply Ability
- 5kg
- Release date
- 2023-05-24