ISOSTEVIOL

Product Name: ISOSTEVIOL
CAS No.: 27975-19-5
Chemical Name: ISOSTEVIOL
Synonyms: ISOSTEVIOL;Nsc 231875;Ccris 6121;Isosteviol-RM;Isosteviol, BR;(-)-Isosteviol;ISOSTEVIOL STANDARD;ISOSTEVIOL USP/EP/BP;Iso-Stevio 27975-19-5;Isosteviol (NSC 231875)
CBNumber: CB8324052
Molecular Formula: C20H30O3
Formula Weight: 318.45
MOL File: 27975-19-5.mol

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ISOSTEVIOL Property

Melting point:: 228.0 to 232.0 °C
Boiling point:: 455.6±38.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO:81.5(Max Conc. mg/mL);255.92(Max Conc. mM)
form: Solid
pka: 4.69±0.60(Predicted)
color: White to Almost white
InChI: InChI=1/C20H30O3/c1-17-9-5-14-18(2)7-4-8-19(3,16(22)23)13(18)6-10-20(14,12-17)11-15(17)21/h13-14H,4-12H2,1-3H3,(H,22,23)/t13-,14?,17-,18+,19+,20-/s3
InChIKey: KFVUFODCZDRVSS-MVXPDRGUNA-N
SMILES: C12CC[C@@]3(C(=O)C[C@@]1(CC[C@]1([H])[C@](C)(C(=O)O)CCC[C@@]21C)C3)C |&1:3,7,10,12,20,r|

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Safety

WGK Germany: 3
HS Code: 2918.30.9000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL82395
Product name: Isosteviol
Purity: phyproof? Reference Substance
Packaging: 20mg
Price: $254
Updated: 2025/07/31

Sigma-Aldrich

Product number: 92273
Product name: Isosteviol
Purity: analytical standard
Packaging: 10mg
Price: $235
Updated: 2022/05/15

TCI Chemical

Product number: I1069
Product name: Isosteviol
Purity: >98.0%(GC)(T)
Packaging: 100mg
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: I1069
Product name: Isosteviol
Purity: >98.0%(GC)(T)
Packaging: 500mg
Price: $349
Updated: 2025/07/31

Usbiological

Product number: 300507
Product name: Isosteviol
Packaging: 20mg
Price: $390
Updated: 2021/12/16

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ISOSTEVIOL Chemical Properties,Usage,Production

Chemical Properties

White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Stevia rebaudiana Bertoni, also known as stevia and sweet grass.

Uses

Isosteviol is a tetracyclic diterpenoid with a beyerane core has drawn attention because it can exhibit antihypertensive activity, reduce blood glucose, suppress cancer cells.

Definition

ChEBI: Isosteviol is a diterpenoid.

Synthesis

57817-89-7

27975-19-5

A new structure based on (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl((4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R )-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methylcyclohepta[a]naphthalene-4-carboxylic acid ester was synthesized by 10% sulfuric acid hydrolysis reaction. The reaction conditions were conventional hydrolysis conditions without additional catalyst or special temperature control. The product was purified in 93% yield with the melting point of 228.4-230.8 °C. The structure of the product was confirmed by IR, 1H NMR, 13C NMR and HRMS.The IR spectrum showed that the characteristic absorption peaks were located at 3448, 2955, 2924, 2848, 1736, 1692, 1453, 1404, 1373, 1320, 1268, 1214, 1180, 1150, 1108, 973, 950, 796, 589 cm-1 . 796, 589 cm-1.1H NMR (400 MHz, CDCl3) δ: 2.64 (dd, J = 18.64, 3.76 Hz, 1H), 2.17 (d, J = 13.40 Hz, 1H), 1.90-1.37 (m, 13H), 1.25 (s, 3H), 1.22-1.14 (m, 3H), 1.06- 1.03 (m, 1H), 0.98 (s, 3H), 0.95-0.88 (m, 1H), 0.78 (s, 3H).13C NMR (100 MHz, CDCl3) δ: 224.22, 184.33, 56.79, 57.62, 56.09, 54.83, 49.73, 49.59, 44.38. 42.02, 40.42, 38.99, 38.34, 32.80, 29.69, 22.32, 20.57, 19.55, 14.04. HRMS (ESI) m/z: [M + Na]+ Calculated value C20H30O3Na 341.2093, measured value 341.2085.

References

[1] Chemistry and Biodiversity, 2013, vol. 10, # 2, p. 177 - 188
[2] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 19, p. 2485 - 2490
[3] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 26 - 40
[4] Journal of Chemical Crystallography, 2009, vol. 39, # 2, p. 108 - 111
[5] Journal of Chemical Crystallography, 2011, vol. 41, # 4, p. 519 - 522

ISOSTEVIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOSTEVIOL Suppliers

Americas 1 Belgium 1 Canada 1 China 173 Europe 1 Germany 1 India 3 Japan 2 United Kingdom 3 United States 18 Global 204

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Tel: 025-84430028 13815430202
Email: sale02@cqherb.com
Country: China
ProdList: 294
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Chengdu Yuxin Technology Co., Ltd.

Tel: 13558691827
Email: yuxinpharma@126.com
Country: China
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RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
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Email: info@chemlin.com.cn
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Chemsky (shanghai) International Co.,Ltd

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Country: China
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Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
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BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
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Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
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View Lastest Price from ISOSTEVIOL manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: ISOSTEVIOL 27975-19-5
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-21

Shanghai Standard Technology Co., Ltd.

Product: Isosteviol 27975-19-5
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-13

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Iso-Stevio 27975-19-5 27975-19-5
Price: US $15.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

27975-19-5, ISOSTEVIOLRelated Search:

Isorhamnetin Isosorbide 3-Isocyanatopropyltriethoxysilane ISOSTEVIOL(P) Cycloheptanone CYCLOPENTADECANE CYCLOUNDECANONE Muscone ISOSTEVIOL Cyclopentadecanone 8-OXOTRIDECANOIC ACID 2,2,4,4-TETRAMETHYLCYCLOPENTANONE (R)-(-)-MUSCONE 8-OXODODECANOIC ACID 8-OXOUNDECANOIC ACID 9,9-DIMETHYL-8-OXODECANOIC ACID 8-OXO-DECANOIC ACID 9-METHYL-8-OXODECANOIC ACID

Isosteviol (NSC 231875)

(4α,8β,13β)-13--Methyl-16-oxo-17-norkauran-18-oic acid

Ccris 6121

Nsc 231875

17-NORKAURAN-18-OIC ACID, 13-METHYL-16-OXO-, (4-ALPHA,8-BETA,13-BETA)-

ISOSTEVIOL

(4-alpha,8-beta,13-beta)-13-methyl-16-oxo-17-norkauran-18-oicacid

13-beta-kauran-18-oicacid,13-methyl-16-oxo-17-nor-8-bet

13-methyl-16-oxo-,(4-alpha,8-beta,13-beta)-17-norkauran-18-oicaci

ISOSTEVIOL STANDARD

Isosteviol, 98%, from Stevia rebaudiana (Bertoni) Hemsl

(4aα,11aα)-4,9,11bβ-Trimethyl-8-oxo-6aα,9α-methanotetradecahydro-1H-cyclohepta[a]naphthalene-4β-carboxylic acid

(8β,13S)-13-Methyl-16-oxo-17-norkauran-18-oic acid

17-Nor-8-beta,13-beta-kauran-18-oic acid, 13-methyl-16-oxo-

Iso-Stevio 27975-19-5

Isosteviol, BR

Isosteviol ((-)-Isosteviol

17-Norkauran-18-oic acid, 13-methyl-16-oxo-, (4α,8β,13β)-

ISOSTEVIOL USP/EP/BP

(4R,4aS,6aR,9S,11aR,11bS)-4,9,11b-trimethyl-8-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid

(-)-Isosteviol

Isosteviol-RM

Isosteviol, 10 mM in DMSO

(4R,4aS,6aR,9S,11aR,11bS)-4,9,11b-Trimethyl-8-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalen-4-carboxylic acid

27975-19-5

7975-19-5

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