Isosilybin

ChemicalBook > CAS DataBase List > Isosilybin

Structure

Product Name: Isosilybin
CAS No.: 72581-71-6
Chemical Name: Isosilybin
Synonyms: Q-100795;Isosilybin;Isosilybinin;ISOSILIBININ;indissolubly;Isosilybin，ISB;ISOSILYBIN hplc;Diosmin Impurity 24;Isosilybin USP/EP/BP;Isosilybin(Mixture A&B)
CBNumber: CB5359479
Molecular Formula: C25H22O10
Formula Weight: 482.44
MOL File: 72581-71-6.mol

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Isosilybin Property

Boiling point:: 793.0±60.0 °C(Predicted)
Density: 1.527±0.06 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.1 mg/ml
pka: 7.39±0.60(Predicted)
form: Solid
color: White-light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89231
Product name: Isosilybin (A + B mixture)
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $732
Updated: 2024/03/01

Cayman Chemical

Product number: 24913
Product name: Isosilybin
Purity: ≥95%
Packaging: 1mg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 24913
Product name: Isosilybin
Purity: ≥95%
Packaging: 5mg
Price: $1087
Updated: 2024/03/01

Cayman Chemical

Product number: 24913
Product name: Isosilybin
Purity: ≥95%
Packaging: 10mg
Price: $2052
Updated: 2024/03/01

Usbiological

Product number: 280565
Product name: Isosilybin
Packaging: 5mg
Price: $595
Updated: 2021/12/16

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Isosilybin Chemical Properties,Usage,Production

Structure

Only silybins and isosilybins contain the 1,4-dioxane ring system in their structure during Silymarin’s primary constituents. Silybin and isosilybin have the same trans conformation of C-2, C-3, C-7′ and C-8′. Silybin is considered the major and most active component of silymarin.

Description

Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC₅₀ = 32 μM) and reduces ADP/Fe³⁺-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

Uses

Isosilybin is useful in the treatment of liver disease

Definition

The flavonolignan isosilybin is one of the components of the flavonoid complex extracted from the seeds of Silybum marianum (milk thistle), designated silymarin. Besides isosilybin, silymarin contains other flavonoids (congeners), such as silybin, 2,3-dehydrosilybin, silydianin, silychristin, isosilychristin, and taxifolin and ca. 20–30% is an undefined polymeric phenolic fraction. However, several recent studies have demonstrated that isosilybin is probably the most potent anticancer agent in silymarin. Isosilybin was shown to possess in vivo anti-proliferative, anti-angiogenic, pro-apoptotic, and cell-cycle modulatory properties. Moreover, isosilybin and especially isosilybin B inhibited the growth of advanced human prostate cancer cells in vivo without any toxic effects[1].

Definition

ChEBI: A flavonolignan isolated from Silybum marianum.

References

[1] Radek Ga?ák . “Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture.” Process Biochemistry 48 1 (2013): Pages 184-189.

Isosilybin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isosilybin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Isosilybin 72581-71-6
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: Isosilybin 72581-71-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Isosilybin 72581-71-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

72581-71-6, IsosilybinRelated Search:

hydroxygenkwanin 4',5-DIHYDROXY-7-METHOXYFLAVONE SILIBININ-N-METHYLGLUCAMINE, 95％（HPLC） Silibinin Dihydromyrcenol (2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[1,4]dioxin-6-yl]-4-chromanone Isosilybin A ISOSILYBIN(P)(PLEASE CALL) MEDICAGOL GARDENIN B PONCIRIN Quercetin-7-O-β-D-glucopyranoside 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Isoimperatorin Isoacteoside ISOVITEXIN isomangiferin Isocorynoxeine

ISOSILIBININ

ISOSILYBIN(PRIMARY STANDARD)

Isosilybinin

Isosilybin (Isosilybinin)

(2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

ISOSILYBIN hplc

Isosilybin (A+B) mixture

-(2,3-Dihydro-2-(4-hydroxy-3-Methoxyphenyl)-3-(hydroxyMethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

Isosilybin

4H-1-Benzopyran-4-one,2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-

Q-100795

Isosilybin (Mixture of Diastereomers)

Isosilybin，ISB

Isosilybin USP/EP/BP

indissolubly

Isosilybin(Mixture A&B)

Diosmin Impurity 24

(2R,3R)-3,5,7-Trihydroxy-2-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one

72581-71-6

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

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