Isosilybin
- Product Name
- Isosilybin
- CAS No.
- 72581-71-6
- Chemical Name
- Isosilybin
- Synonyms
- Q-100795;Isosilybin;Isosilybinin;ISOSILIBININ;indissolubly;Isosilybin,ISB;ISOSILYBIN hplc;Diosmin Impurity 24;Isosilybin USP/EP/BP;Isosilybin(Mixture A&B)
- CBNumber
- CB5359479
- Molecular Formula
- C25H22O10
- Formula Weight
- 482.44
- MOL File
- 72581-71-6.mol
Isosilybin Property
- Boiling point:
- 793.0±60.0 °C(Predicted)
- Density
- 1.527±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.1 mg/ml
- pka
- 7.39±0.60(Predicted)
- form
- Solid
- color
- White-light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHL89231
- Product name
- Isosilybin (A + B mixture)
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $732
- Updated
- 2024/03/01
- Product number
- 24913
- Product name
- Isosilybin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- 24913
- Product name
- Isosilybin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1087
- Updated
- 2024/03/01
- Product number
- 24913
- Product name
- Isosilybin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $2052
- Updated
- 2024/03/01
- Product number
- 280565
- Product name
- Isosilybin
- Packaging
- 5mg
- Price
- $595
- Updated
- 2021/12/16
Isosilybin Chemical Properties,Usage,Production
Description
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.
Uses
Isosilybin is useful in the treatment of liver disease
Uses
Useful in the treatment of liver disease.
Definition
ChEBI: A flavonolignan isolated from Silybum marianum.
Isosilybin Preparation Products And Raw materials
Raw materials
Preparation Products
Isosilybin Suppliers
View Lastest Price from Isosilybin manufacturers
- Product
- Isosilybin 72581-71-6
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 100 g
- Release date
- 2020-08-12
- Product
- Isosilybin 72581-71-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Isosilybin 72581-71-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31