Dihydromyricetin
- Product Name
- Dihydromyricetin
- CAS No.
- 27200-12-0
- Chemical Name
- Dihydromyricetin
- Synonyms
- ampeloptin;AMPELOPSIN;Two hydrogenMyricetin;vine tea extract dihydromyricetin;DihydroMyricetin, froM Myrica rubra;3,3’,4’,5,5’,7-hexahydroxy-flavanon;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3',4',5,5;,(2r-trans)-
- CBNumber
- CB1670507
- Molecular Formula
- C15H12O8
- Formula Weight
- 320.25
- MOL File
- 27200-12-0.mol
Dihydromyricetin Property
- storage temp.
- -20°C
- solubility
- DMSO: ≥5mg/mL (warmed)
- Density
- 1.808±0.06 g/cm3(Predicted)
- form
- powder
- Boiling point:
- 780.7±60.0 °C(Predicted)
- Melting point:
- 239-241 °C
- pka
- 7.38±0.60(Predicted)
- color
- white to beige
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
- InChIKey
- KJXSIXMJHKAJOD-LSDHHAIUSA-N
- SMILES
- [C@H]1(C2=CC(O)=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
- LogP
- 1.230 (est)
- CAS DataBase Reference
- 27200-12-0
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29329990
N-Bromosuccinimide Price
- Product number
- 42866
- Product name
- Dihydromyricetin
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $176
- Updated
- 2022/05/15
- Product number
- D5464
- Product name
- Dihydromyricetin
- Purity
- >97.0%(HPLC)
- Packaging
- 200mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- D5464
- Product name
- Dihydromyricetin
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $511
- Updated
- 2024/03/01
- Product number
- 23549
- Product name
- Dihydromyricetin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 23549
- Product name
- Dihydromyricetin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $129
- Updated
- 2024/03/01
Dihydromyricetin Chemical Properties,Usage,Production
Description
Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound, which is found in large quantities in Asian plant species. One of them – Hovenia dulcis – is known for centuries in traditional Chinese medicine as a cure for alcohol poisoning and hangover (Liang et al. 2014). DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties.
Dihydromyricetin had beneficial effects on health such as antimicrobial, anti-inflammatory,antioxidative, anticancer, lipid and glucose metabolism-regulatory activities，and cell death-mediating without or with minimum adverse effects on normal cells. And most importantly, DHM has been shown to provide significant hepatoprotective effects. Its positive influence on alcohol-induced and other liver diseases was suggested in the study of acute liver failure (Liu et al. 2017).
Uses
Dihydromyricetin has been used to study its effect on adipogenesis and glucose uptake in differentiated 3T3-L1 pre-adipocytes. It has also been used to study its antitumor activity against liver cancer cells.
Definition
ChEBI: (+)-dihydromyricetin is an optically active form of dihydromyricetin having (2R,3R)-configuration. It has a role as a metabolite, an antioxidant and an antineoplastic agent. It is a secondary alpha-hydroxy ketone and a dihydromyricetin. It is an enantiomer of a (-)-dihydromyricetin.
benefits
Dihydromyricetin (DHM) relieves alcohol toxicity and prevents intoxication by limiting the absorption of alcohol in the gastrointestinal tract and promoting the metabolisation of alcohol in the liver. DHM is a promising compound for kidney protection, liver protection, and neurological protection when drinking alcohol.
DHM benefits can include things like:
relieve hangover
relieve anxiety
cardioprotective properties
protect the liver
Biochem/physiol Actions
Dihydromyricetin (Ampelopsin) is a flavanonol with antioxidant and anti-cancer activity, found to have anti-alcohol intoxication effects. Its anti-alcohol effects appear to be by its actions as a positive modulator of GABA-A receptors at the benzodiazepine site.
Clinical Use
Dihydromyricetin can be used as a novel anti-alcoholism drug, clinically used to treat hangovers, fever, parasitic infections and liver disease. It is currently being studied in clinical trials for its effects on glycaemic control, insulin sensitivity and insulin secretion in type 2 diabetes.
Side effects
Dihydromyricetin has been used in Asia for thousands of years as a hangover cure and anti-intoxication medicine and is considered safe for humans even in massive doses.
In a DHM toxicity study, researchers failed to find any side-effects while giving mice massive doses of up to 22g/kg body weight.
Acute toxicity tests showed that a single dose of oral SHE up to 22 g/kg did not result in any death or toxic side effects in mice during 14 days'observation.
Conversions from rat to human pharmacology can be estimated using the HED ratio of 16%, giving DHM a safe upper limit dosage of 15.68g for a 70kg person.
Dihydromyricetin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dihydromyricetin manufacturers
- Product
- Dihydromyricetin 27200-12-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%HPLC
- Supply Ability
- 1 ton
- Release date
- 2024-11-07
- Product
- Dihydromyricetin Powder 27200-12-0
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-17
- Product
- vine tea extract dihydromyricetin 27200-12-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 1%-98% HPLC
- Supply Ability
- 1000kg
- Release date
- 2022-11-15