ChemicalBook > CAS DataBase List > 2-BROMO-1-FLUORO-4-IODOBENZENE

2-BROMO-1-FLUORO-4-IODOBENZENE

Product Name: 2-BROMO-1-FLUORO-4-IODOBENZENE
CAS No.: 811842-30-5
Chemical Name: 2-BROMO-1-FLUORO-4-IODOBENZENE
Synonyms: 2-Bromo-4-iodofluorobenzene;3-BROMO-4-FLUORO IODOBENZENE;3-bromo-4-fluoro-1-iodobenzene;1-Bromo-2-fluoro-5-iodobenzene;2-BROMO-1-FLUORO-4-IODOBENZENE;3-Bromo-4-fluoroiodobenzene 98%;Benzene,2-broMo-1-fluoro-4-iodo-;2-BROMO-1-FLUORO-4-IODOBENZENE ISO 9001：2015 REACH
CBNumber: CB1670789
Molecular Formula: C6H3BrFI
Formula Weight: 300.89
MOL File: 811842-30-5.mol

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2-BROMO-1-FLUORO-4-IODOBENZENE Property

Boiling point:: 243℃
Density: 2.281
Flash point:: 101℃
storage temp.: 2-8°C(protect from light)
Appearance: Light yellow to light brown Liquid
InChI: InChI=1S/C6H3BrFI/c7-5-3-4(9)1-2-6(5)8/h1-3H
InChIKey: LHRMBQARSBULRX-UHFFFAOYSA-N
SMILES: C1(F)=CC=C(I)C=C1Br

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B692308
Product name: 2-Bromo-1-fluoro-4-iodobenzene
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B692308
Product name: 2-Bromo-1-fluoro-4-iodobenzene
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B692308
Product name: 2-Bromo-1-fluoro-4-iodobenzene
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 1600-U-05
Product name: 2-Bromo-1-fluoro-4-iodobenzene
Purity: 98%
Packaging: 25g
Price: $84
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB67663
Product name: 2-Bromo-1-fluoro-4-iodobenzene
Packaging: 250g
Price: $200
Updated: 2021/12/16

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2-BROMO-1-FLUORO-4-IODOBENZENE Chemical Properties,Usage,Production

Chemical Properties

light yellow liquid

Synthesis

656-64-4

811842-30-5

The general procedure for the synthesis of 2-bromo-1-fluoro-4-iodobenzene from 3-bromo-4-fluoroaniline is as follows: in a 1L four-necked round-bottomed flask equipped with a stirrer, a Liebig condenser, a 100mL dropping funnel, and a thermometer, 630mL of water, 84mL (0.926mol) of concentrated hydrochloric acid, and 54.7g (0.241 mol) of 3-bromo-4-fluoroaniline were added at room temperature and stirred for 24 hours. Subsequently, the reaction mixture was cooled to -10 °C with an ice-water bath and 19.0 g (0.270 mol) of sodium nitrite in 63 mL of aqueous solution was slowly added dropwise, controlling the temperature not to exceed 5 °C during the dropwise addition. After the dropwise addition was completed, stirring was continued at 5 °C or lower for 30 min, and the reaction solution was filtered through a filter aid to obtain an aqueous solution of the diazonium salt. In another 2L four-necked round-bottomed flask equipped with a stirrer, an Erlenmeyer condenser, a 1L dropping funnel, and a thermometer, 42.0 g (0.251 mol) of potassium iodide and 125 mL of water were added, and the mixture was cooled to 10°C and stirred. Subsequently, the aqueous diazonium salt solution prepared above was slowly added dropwise. Upon completion of the dropwise addition, the ice water bath was removed and the reaction mixture was allowed to warm naturally to room temperature, then heated to 40 °C and stirred at that temperature for 4 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, 270 mL of dichloromethane (DCM) was added, and transferred to a 2L dispensing funnel to separate the aqueous layer. The aqueous layer was extracted with 220 mL of DCM, and the organic layer was combined and washed three times with 220 mL of 20% aqueous sodium thiosulfate, 220 mL of saturated saline, and 220 mL of water, in that order. The organic layer was dried over anhydrous magnesium sulfate, filtered to remove the desiccant, and distilled under reduced pressure to remove the solvent to obtain the crude product. The crude product was purified by silica gel column chromatography with n-heptane as the unfolding agent, and 62.5 g (86.0% yield) of 2-bromo-1-fluoro-4-iodobenzene was finally obtained.

References

[1] Patent: JP2018/90561, 2018, A. Location in patent: Paragraph 0088
[2] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 45

2-BROMO-1-FLUORO-4-IODOBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-1-FLUORO-4-IODOBENZENE Suppliers

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View Lastest Price from 2-BROMO-1-FLUORO-4-IODOBENZENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-BROMO-1-FLUORO-4-IODOBENZENE 811842-30-5
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Career Henan Chemical Co

Product: 2-BROMO-1-FLUORO-4-IODOBENZENE 811842-30-5
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

811842-30-5, 2-BROMO-1-FLUORO-4-IODOBENZENERelated Search:

2-BROMO-3,4-DIFLUOROBENZOIC ACID 2-BROMO-5-NITROBENZOIC ACID 2-BROMO-6-CHLOROBENZOTRIFLUORIDE 2-BROMO-4-FLUORO-1-IODOBENZENE 3-FLUORO-5-IODO BROMOBENZENE 4-BROMO-1-FLUORO-2-IODOBENZENE,98% 1-BROMO-3-FLUORO-4-IODOBENZENE 1,3-Dibromo-5-fluoro-2-iodobenzene 5-Bromo-2-fluoro-1-iodobenzene 1-Fluoro-4-iodobenzene 1-BROMO-4-FLUORO-2-IODOBENZENE,1-Bromo-4-fluoro-2-iodobenzene97%,1-BROMO-4-FLUORO-2-IODOBENZENE, 98+%,2-Bromo-5-fluoro-1-iodobenzene 1-BROMO-2-FLUORO-4-IODOBENZENE,1-Bromo-2-fluoro-4-iodobenzene,98%,1-Bromo-2-fluoro-4-iodobenzene 98% 1-BROMO-3-FLUORO-5-IODOBENZENE 2-BROMO-1-FLUORO-3-IODOBENZENE 1-BROMO-4-FLUORO-3-IODOBENZENE 1-BROMO-3-FLUORO-2-IODOBENZENE 4-BROMO-1-FLUORO-2-IODOBENZENE 99% 4-BROMO-1-FLUORO-2-IODOBENZENE

3-BROMO-4-FLUORO IODOBENZENE

2-BROMO-1-FLUORO-4-IODOBENZENE

1-Bromo-2-fluoro-5-iodobenzene

3-Bromo-4-fluoroiodobenzene 98%

Benzene,2-broMo-1-fluoro-4-iodo-

2-BROMO-1-FLUORO-4-IODOBENZENE ISO 9001：2015 REACH

2-Bromo-4-iodofluorobenzene

3-bromo-4-fluoro-1-iodobenzene

811842-30-5

Fluorine series

Fluorinated benzene series

Aromatic Halides (substituted)

Bromine Compounds

Fluorine Compounds

Iodine Compounds