4-Bromo-1-fluoro-2-iodobenzene
- Product Name
- 4-Bromo-1-fluoro-2-iodobenzene
- CAS No.
- 116272-41-4
- Chemical Name
- 4-Bromo-1-fluoro-2-iodobenzene
- Synonyms
- 3-Iodo-4-fluorobromobenzene;5-Bromo-2-fluoroiodobenzene;2-Iodo-4-bromofluorobenzene;2-fluoro-5-bromo-iodobenzene;4-FLUORO-3-IODO BROMOBENZENE;5-Bromo-2-fluoro-1-iodobenzene;4-Bromo-1-fluoro-2-iodobenzene;4-Bromo-1-fluoro-4-iodobenzene;5-Bromo-2-fluoroiodobenzene 99%;Benzene, 4-bromo-1-fluoro-2-iodo-
- CBNumber
- CB9971774
- Molecular Formula
- C6H3BrFI
- Formula Weight
- 300.89
- MOL File
- 116272-41-4.mol
4-Bromo-1-fluoro-2-iodobenzene Property
- Boiling point:
- 247.4±25.0 °C(Predicted)
- Density
- 2.281
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- form
- liquid
- color
- Clear, colourless
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C6H3BrFI/c7-4-1-2-5(8)6(9)3-4/h1-3H
- InChIKey
- JNETZJWWXCLUKM-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(Br)C=C1I
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B692333
- Product name
- 4-Bromo-1-fluoro-2-iodobenzene
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC2532
- Product name
- 5-Bromo-2-fluoroiodobenzene
- Purity
- 99%
- Packaging
- 100g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- 020562
- Product name
- 4-Bromo-1-fluoro-2-iodobenzene
- Purity
- 98%
- Packaging
- 100g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- J97185
- Product name
- 4-Bromo-1-fluro-2-iodobenzene
- Packaging
- 100g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 1600-U-02
- Product name
- 5-Bromo-2-fluoroiodobenzene
- Purity
- 99%
- Packaging
- 100g
- Price
- $77
- Updated
- 2021/12/16
4-Bromo-1-fluoro-2-iodobenzene Chemical Properties,Usage,Production
Chemical Properties
Yellow crstalline
Uses
4-Bromo-1-fluoro-2-iodobenzene is a polyhalogenated benzene derivative containing substitutable reactive groups of fluorine, bromine and iodine atoms in its molecular structure. It is mainly used as a molecular building block, organic synthesis or pharmaceutical intermediate compound, and is a raw material for the preparation of other aromatic alkanes or heterocyclic compounds.
Synthesis
2924-09-6
116272-41-4
Under argon protection, 5-bromo-2-fluoroaniline (45.6 g, 240 mmol) was dissolved in water (120 mL), stirred and concentrated hydrochloric acid (120 mL) was added slowly. After the reaction mixture was cooled to -20 °C, aqueous sodium nitrite (19.9 g, 288 mmol dissolved in 80 mL of water) was added dropwise. Stirring was continued at -20 °C for 20 min, followed by the addition of aqueous potassium iodide solution (59.8 g, 360 mmol dissolved in 60 mL of water) and stirring was continued for 30 min. After completion of the reaction, the reaction mixture was extracted with hexane and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and sodium sulfite solutions and dried over anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography to afford 5-bromo-2-fluoroiodobenzene (54.6 g, 181 mmol) in 76% yield.
References
[1] Patent: KR2016/18458, 2016, A. Location in patent: Paragraph 0309-0311
[2] Patent: EP2924029, 2015, A1. Location in patent: Paragraph 0130; 0131
4-Bromo-1-fluoro-2-iodobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-1-fluoro-2-iodobenzene manufacturers
- Product
- 3-Iodo-4-fluorobromobenzene 116272-41-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2023-07-03
- Product
- 3-Iodo-4-fluorobromobenzene 116272-41-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 3-Iodo-4-fluorobromobenzene 116272-41-4
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-20