4-Bromo-2-fluoroaniline
- Product Name
- 4-Bromo-2-fluoroaniline
- CAS No.
- 367-24-8
- Chemical Name
- 4-Bromo-2-fluoroaniline
- Synonyms
- 2-Fluoro-4-Bromoaniline;4-BROMO-2-FLUORO-PHENYLAMINE;4-Bromo-2-fL;AKOS BBS-00003609;Bromofluoroaniline4;4-Bromo-2-fluoroanil;4-Brom-2-fluoranilin;Fluoro-4-bromoaniline;Vandetanib Impurity 2;4-BROMO-2-FLUOROANILINE
- CBNumber
- CB2765000
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 367-24-8.mol
4-Bromo-2-fluoroaniline Property
- Melting point:
- 40-42 °C
- Boiling point:
- 103-108 °C (13 mmHg)
- Density
- 1.6196 (rough estimate)
- refractive index
- 1.4710 (estimate)
- Flash point:
- 220 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.50±0.10(Predicted)
- form
- Crystalline Mass, Powder, Crystals and/or Chunks
- color
- Beige to light brown to brown-gray or gray
- BRN
- 2081089
- Stability:
- Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents.
- InChI
- InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
- InChIKey
- GZRMNMGWNKSANY-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Br)C=C1F
- CAS DataBase Reference
- 367-24-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Bromo-2-fluoroaniline(367-24-8)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-36
- RIDADR
- UN2811
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 304220
- Product name
- 4-Bromo-2-fluoroaniline
- Purity
- 98%
- Packaging
- 10g
- Price
- $47.2
- Updated
- 2024/03/01
- Product number
- 304220
- Product name
- 4-Bromo-2-fluoroaniline
- Purity
- 98%
- Packaging
- 50g
- Price
- $64.2
- Updated
- 2024/03/01
- Product number
- B1314
- Product name
- 4-Bromo-2-fluoroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $72
- Updated
- 2024/03/01
- Product number
- A10228
- Product name
- 4-Bromo-2-fluoroaniline, 98+%
- Packaging
- 10g
- Price
- $20.65
- Updated
- 2024/03/01
- Product number
- A10228
- Product name
- 4-Bromo-2-fluoroaniline, 98+%
- Packaging
- 25g
- Price
- $39.65
- Updated
- 2024/03/01
4-Bromo-2-fluoroaniline Chemical Properties,Usage,Production
Chemical Properties
solid
Uses
4-Bromo-2-fluoroaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Uses
4-Bromo-2-fluoroaniline was used in synthesis of 4-amino-3-fluorophenyl boronic acid. It was also used in chemical modification and synthesis of boronic acid derivatives for ultraviolet-visible titration.
Synthesis
To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 ??C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline.
4-Bromo-2-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-fluoroaniline manufacturers
- Product
- 4-Bromo-2-fluoroaniline 367-24-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
- Product
- 4-Bromo-2-Fluoroaniline 367-24-8
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.6%
- Supply Ability
- 100000
- Release date
- 2024-04-28
- Product
- 4-Bromo-2-fluoroaniline 367-24-8
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22