4-BROMO-2,5-DIFLUORONITROBENZENE

Product Name: 4-BROMO-2,5-DIFLUORONITROBENZENE
CAS No.: 167415-27-2
Chemical Name: 4-BROMO-2,5-DIFLUORONITROBENZENE
Synonyms: BUTTPARK 29\01-58;2,5-Difluoro-4-bromonitrobenzene;4-BROMO-2,5-DIFLUORONITROBENZENE;5-Bromo-1,4-difluoro-2-nitrobenzene;1-BROMO-2,5-DIFLUORO-4-NITROBENZENE;4-Bromo-2,5-difluoronitrobenzene >Benzene, 1-bromo-2,5-difluoro-4-nitro-;4-BROMO-2,5-DIFLUORONITROBENZENE ISO 9001：2015 REACH
CBNumber: CB9300651
Molecular Formula: C6H2BrF2NO2
Formula Weight: 237.99
MOL File: 167415-27-2.mol

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4-BROMO-2,5-DIFLUORONITROBENZENE Property

Melting point:: 55 °C
Boiling point:: 262.4±35.0 °C(Predicted)
Density: 1.890±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: Light orange to Yellow to Green
BRN: 7411347
CAS DataBase Reference: 167415-27-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36/37/39-36/37
Hazard Note: Irritant
HazardClass: IRRITANT, TOXIC
HS Code: 29042090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3926
Product name: 4-Bromo-2,5-difluoronitrobenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: B3926
Product name: 4-Bromo-2,5-difluoronitrobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $90
Updated: 2025/07/31

TRC

Product number: B690313
Product name: 4-Bromo-2,5-difluoronitrobenzene
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B690313
Product name: 4-Bromo-2,5-difluoronitrobenzene
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105820
Product name: 1-bromo-2,5-difluoro-4-nitrobenzene
Packaging: 250g
Price: $500
Updated: 2021/12/16

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4-BROMO-2,5-DIFLUORONITROBENZENE Chemical Properties,Usage,Production

Chemical Properties

light yellow solid

Synthesis

399-94-0

167415-27-2

General procedure for the synthesis of 4-bromo-2,5-difluoronitrobenzene from 2,5-difluorobromobenzene: Referring to Example-50, a mixture of acids was prepared by cooling concentrated sulfuric acid (57 mL) in an ice bath, followed by the slow dropwise addition of 69% nitric acid (25.5 g, 279 mmol) over a period of 25 minutes. A dichloroethane (125 mL) solution of 2-bromo-1,4-difluorobenzene (50 g, 254 mmol) was added slowly dropwise over 1.5 h to the above mixed acid under ice bath cooling conditions. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction solution was slowly poured into ice water (500 g) and extracted with ether (300 mL x 2). The organic phases were combined and washed sequentially with water (300 mL), saturated aqueous sodium bicarbonate solution (300 mL) and saturated saline (300 mL). The organic layer was dried over anhydrous magnesium sulfate and then distilled under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/chloroform=4:1) to afford 1-bromo-2,5-difluoro-4-nitrobenzene (56 g, yield: 93%) as a pale yellow solid.1H-NMR (400 MHz, CDCl3): δ 7.59 (dd, J=9.5 and 5.5 Hz, 1H), 7.89 (dd, J=7.3 and 6.5 Hz, 1H).19F-NMR (376 MHz, CDCl3): δ -120.1 (d, J=15.2 Hz, 1F), -107.9 (d, J=15.2 Hz, 1F).

References

[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0809; 0810
[2] Patent: JP2016/56157, 2016, A. Location in patent: Paragraph 0164; 0168
[3] Patent: JP2016/60742, 2016, A. Location in patent: Paragraph 0251
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 22, p. 4367 - 4379
[5] Journal of Organic Chemistry, 1995, vol. 60, # 18, p. 5838 - 5842

4-BROMO-2,5-DIFLUORONITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-2,5-DIFLUORONITROBENZENE Suppliers

Americas 1 China 139 Europe 1 Germany 2 India 6 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 10 United States 23 Global 185

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View Lastest Price from 4-BROMO-2,5-DIFLUORONITROBENZENE manufacturers

Career Henan Chemical Co

Product: 4-BROMO-2,5-DIFLUORONITROBENZENE 167415-27-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-12

167415-27-2, 4-BROMO-2,5-DIFLUORONITROBENZENERelated Search:

2-Bromo-4,5-difluoronitrobenzene 2-Bromo-3,4-Difluoronitrobenzene 1-Bromo-4-nitrobenzene 4-BROMO-2,5-DIFLUORONITROBENZENE 1-Bromo-2-fluoro-4-nitrobenzene 1-Bromo-2,5-difluorobenzene 2-Bromofluorobenzene 2-Fluoro-4-bromonitrobenzene 4-Bromo-2-fluoroaniline 4-BROMO-2,5-DIFLUOROANILINE 3-Fluoro-4-broMoaniline 2,5-Difluoronitrobenzene 3-Bromofluorobenzene Nitrobenzene 5-BROMO-2,4-DIFLUORONITROBENZENE 3-BROMO-4,5-DIFLUORONITROBENZENE 2-BROMO-3,5-DIFLUORONITROBENZENE 2-BROMO-4,6-DIFLUORONITROBENZENE

1-BROMO-2,5-DIFLUORO-4-NITROBENZENE

5-Bromo-1,4-difluoro-2-nitrobenzene

BUTTPARK 29\01-58

4-BROMO-2,5-DIFLUORONITROBENZENE

2,5-Difluoro-4-bromonitrobenzene

4-Bromo-2,5-difluoronitrobenzene &gt

Benzene, 1-bromo-2,5-difluoro-4-nitro-

4-BROMO-2,5-DIFLUORONITROBENZENE ISO 9001：2015 REACH

167415-27-2

C6H2BrF2NO2