2-BROMO-4,6-DIFLUORONITROBENZENE

Product Name: 2-BROMO-4,6-DIFLUORONITROBENZENE
CAS No.: 884494-38-6
Chemical Name: 2-BROMO-4,6-DIFLUORONITROBENZENE
Synonyms: 2-BROMO-4,6-DIFLUORONITROBENZENE;1-broMo-3,5-difluoro-2-nitrobenzene;Benzene, 1-bromo-3,5-difluoro-2-nitro-;2-BROMO-4,6-DIFLUORONITROBENZENE ISO 9001：2015 REACH
CBNumber: CB5766295
Molecular Formula: C6H2BrF2NO2
Formula Weight: 237.99
MOL File: Mol file

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2-BROMO-4,6-DIFLUORONITROBENZENE Property

Boiling point:: 226.9±35.0 °C(Predicted)
Density: 1.890±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: crystalline powder
color: Off-white to faint yellow

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Safety

HS Code: 2904990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B690308
Product name: 2-Bromo-4,6-difluoronitrobenzene
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 074450
Product name: 2-Bromo-4,6-difluoronitrobenzene
Purity: 95+%
Packaging: 1g
Price: $98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105819
Product name: 1-Bromo-3,5-difluoro-2-nitrobenzene
Packaging: 25g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J51189
Product name: 2-Bromo-4,6-difluoronitrobenzene
Packaging: 25g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-N-00
Product name: 2-Bromo-4,6-difluoronitrobenzene
Packaging: 25g
Price: $136
Updated: 2021/12/16

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2-BROMO-4,6-DIFLUORONITROBENZENE Chemical Properties,Usage,Production

Uses

2-Bromo-4,6-difluoronitrobenzene is a polysubstituted fluoronitrobenzene analogue that can be used to prepare pyrazolylamino benzimidazole derivatives as JAK inhibitors.

Synthesis

461-96-1

884494-38-6

Fuming nitric acid (20 mL) was slowly added dropwise to a solution of 1-bromo-3,5-difluorobenzene (35.00 mL, 304 mmol) dissolved in sulfuric acid (50 mL) at 0 °C. The reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction mixture was carefully poured into an ice-water mixture (600 mL) and subsequently slowly warmed to room temperature. Ethyl acetate (200 mL) and hexane (100 mL) were added and stirred until all solids were completely dissolved. The organic layer was separated, washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give 2-bromo-4,6-difluoronitrobenzene as a yellow oil (57.37 g, 79% yield).GCMS analysis showed m/z = 237,239 (corresponding to Br isotope pattern).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5243 - 5263
[2] Patent: US9556153, 2017, B1. Location in patent: Page/Page column 8
[3] Patent: WO2018/13486, 2018, A1. Location in patent: Page/Page column 13

2-BROMO-4,6-DIFLUORONITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4,6-DIFLUORONITROBENZENE Suppliers

China 95 India 2 United Kingdom 2 United States 8 Global 107

Energy Chemical

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View Lastest Price from 2-BROMO-4,6-DIFLUORONITROBENZENE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-bromo-3,5-difluoro-2-nitrobenzene 884494-38-6
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-19

Career Henan Chemical Co

Product: 2-BROMO-4,6-DIFLUORONITROBENZENE 884494-38-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

884494-38-6, 2-BROMO-4,6-DIFLUORONITROBENZENERelated Search:

2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 2-Bromo-4-nitrobenzaldehyde 2-Bromo-4-methylthiazole 2-Bromo-4-fomylthiazole 2-BROMO-4-(4-BROMO-PHENYL)-THIAZOLE 2-BROMO-5-IODOTHIAZOLE 2-BROMO-4-CYANOTHIAZOLE (2-Bromo-4-nitrophenyl)methanol 2-BROMO-4-METHOXYBENZOTHIAZOLE 2-BROMO-4-METHYLBENZOTHIAZOLE 2-BroMo-4-chloro-3-Methylpyridine 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 2-Bromo-4-chloro-3-fluoropyridine Benzaldehyde, 2-broMo-4-hydroxy 2-BroMo-4-(trifluoroMethyl)thiazole 2-Bromo-4,5-dimethyl-1,3-thiazole 2-BROMO-4-CHLOROBENZOTHIAZOLE 3-(2-BROMO-THIAZOL-4-YL)-PYRIDINE

1-broMo-3,5-difluoro-2-nitrobenzene

2-BROMO-4,6-DIFLUORONITROBENZENE

Benzene, 1-bromo-3,5-difluoro-2-nitro-

2-BROMO-4,6-DIFLUORONITROBENZENE ISO 9001：2015 REACH

884494-38-6