2-BroMo-4-chloro-3-Methylpyridine
- Product Name
- 2-BroMo-4-chloro-3-Methylpyridine
- CAS No.
- 1211521-46-8
- Chemical Name
- 2-BroMo-4-chloro-3-Methylpyridine
- Synonyms
- 2-BroMo-4-chloro-3-Methylpyridin;2-BroMo-4-chloro-3-Methylpyridine;2-bromo-3-methyl-4-chloropyridine;Pyridine, 2-bromo-4-chloro-3-methyl-
- CBNumber
- CB42725592
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 1211521-46-8.mol
2-BroMo-4-chloro-3-Methylpyridine Property
- Boiling point:
- 241.8±35.0 °C(Predicted)
- Density
- 1.624±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.38±0.10(Predicted)
- Appearance
- Yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y1540
- Product name
- 2-bromo-4-chloro-3-methylpyridine
- Packaging
- 1g
- Price
- $458
- Updated
- 2021/12/16
- Product number
- A264156
- Product name
- 2-Bromo-4-chloro-3-methylpyridine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $42
- Updated
- 2021/12/16
- Product number
- A264156
- Product name
- 2-Bromo-4-chloro-3-methylpyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 69R1379
- Product name
- 2-Bromo-4-chloro-3-methyl-pyridine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- AA10-2306
- Product name
- 2-Bromo-4-chloro-3-methyl-pyridine
- Purity
- ＞95%
- Packaging
- 1g
- Price
- $205
- Updated
- 2021/12/16
2-BroMo-4-chloro-3-Methylpyridine Chemical Properties,Usage,Production
Synthesis
22918-01-0
74-88-4
1211521-46-8
General procedure for the synthesis of 2-bromo-4-chloro-3-methylpyridine from 2-bromo-4-chloropyridine and iodomethane: To a solution of 2,2,6,6-tetramethylpyridine (21.1 mL, 125 mmol) dissolved in freshly distilled tetrahydrofuran (THF, 120 mL) at -78 °C was added slowly over 30 min n-butyl lithium (nBuLi, 50 mL 125 mmol). The resulting mixture was stirred at -78 °C for 30 min. The above mixture was added to a solution of 3-bromo-4-chloropyridine (20.0 g, 104 mmol) dissolved in freshly distilled THF (60 mL) that had been cooled to -78 °C via cannula over 30 min. The reaction mixture was continued to be stirred at -78 °C for 30 min, followed by the addition of iodomethane (7.78 mL, 125 mmol) over 10 min. After stirring the reaction mixture at -78 °C for 30 min, it was slowly warmed to room temperature and the reaction was quenched with aqueous ammonium chloride (NH4Cl) (65 mL). The aqueous phase was extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated. The residue was purified by fast silica gel column chromatography (eluent: hexane/ethyl acetate, 5:1) to afford 2-bromo-4-chloro-3-methylpyridine as a yellow solid (10.6 g, 49% yield).1H NMR (CDCl3, 300 MHz) δ ppm: 8.10 (d, J = 5.1 Hz, 1H), 7.27 (d, J = 5.1 Hz, 1H) 2.51 (s, 3H).
References
[1] Patent: EP3034078, 2016, A1. Location in patent: Paragraph 0139-0140
2-BroMo-4-chloro-3-Methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BroMo-4-chloro-3-Methylpyridine manufacturers
- Product
- 2-BroMo-4-chloro-3-Methylpyridine 1211521-46-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29