2-Bromo-4-chloro-3-fluoropyridine
- Product Name
- 2-Bromo-4-chloro-3-fluoropyridine
- CAS No.
- 1155847-42-9
- Chemical Name
- 2-Bromo-4-chloro-3-fluoropyridine
- Synonyms
- 2-Bromo-4-chloro-3-fluoropyridine;Pyridine, 2-bromo-4-chloro-3-fluoro-
- CBNumber
- CB22742508
- Molecular Formula
- C5H2BrClFN
- Formula Weight
- 210.43
- MOL File
- 1155847-42-9.mol
2-Bromo-4-chloro-3-fluoropyridine Property
- Boiling point:
- 205.4±35.0 °C(Predicted)
- Density
- 1.829±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.13±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2530AA
- Product name
- 2-Bromo-4-chloro-3-fluoropyridine
- Packaging
- 250mg
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 2530AA
- Product name
- 2-Bromo-4-chloro-3-fluoropyridine
- Packaging
- 1g
- Price
- $294
- Updated
- 2021/12/16
- Product number
- A141043
- Product name
- 2-Bromo-4-chloro-3-fluoropyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $609
- Updated
- 2021/12/16
- Product number
- A141043
- Product name
- 2-Bromo-4-chloro-3-fluoropyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $609
- Updated
- 2021/12/16
- Product number
- CM174912
- Product name
- 2-bromo-4-chloro-3-fluoropyridine
- Purity
- 96%
- Packaging
- 1g
- Price
- $617
- Updated
- 2021/12/16
2-Bromo-4-chloro-3-fluoropyridine Chemical Properties,Usage,Production
Synthesis
2546-56-7
1155847-42-9
General procedure for the synthesis of 2-bromo-4-chloro-3-fluoropyridine from 4-chloro-3-fluoropyridine: 1. Intermediate 101A. 2-Bromo-4-chloro-3-fluoropyridine was prepared by slowly adding 1.6 M hexane solution of n-butyllithium (n-BuLi) (5.23 mL, 8.36 mmol) dropwise to a tetrahydrofuran (THF, 40 mL) solution of 2,2,6,6-tetramethylpiperidine (1.54 mL, 9.12 mmol) at -78 °C. 2. The reaction solution was warmed to 0 °C and stirred for 0.5 hours. 3. The reaction solution was again cooled to -78 °C and a solution of 4-chloro-3-fluoropyridine (0.769 mL, 7.60 mmol) in THF (5 mL) was added dropwise over 30 min. 4. Stirring was continued at -78 °C for 30 min. 5. A solution of N-bromosuccinimide (NBS, 1.624 g, 9.12 mmol) in THF (25 mL) was added dropwise to the reaction solution. 6. The reaction solution was stirred at -78 °C for 1 hour, then brought to room temperature and stirred for 12 hours. 7. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and water. 8. The organic layer was separated, washed with brine, concentrated and purified by silica gel column chromatography to afford the target product 2-bromo-4-chloro-3-fluoropyridine (0.541 g, 34%) as an orange oil (volatile). 9. 9. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.13 (d, J = 5.0 Hz, 1H), 7.35 (t, J = 5.1 Hz, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 24, p. 7344 - 7350
[2] Patent: WO2013/22818, 2013, A1. Location in patent: Paragraph 00408
[3] Patent: WO2009/67166, 2009, A2. Location in patent: Page/Page column 114-115
2-Bromo-4-chloro-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4-chloro-3-fluoropyridine Suppliers
- Tel
- 029-68669089-8816
- Fax
- +86-29-68669073
- market@xarlm.com
- Country
- China
- ProdList
- 499
- Advantage
- 55
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0512-0512-52358471 17715136450
- Fax
- 05125235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 12127
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-65232103 17602124823
- combiphos@vip.qq.com
- Country
- China
- ProdList
- 30000
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9713
- Advantage
- 58
View Lastest Price from 2-Bromo-4-chloro-3-fluoropyridine manufacturers
- Product
- 2-Bromo-4-chloro-3-fluoropyridine 1155847-42-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%min
- Supply Ability
- 2000Kg
- Release date
- 2023-11-06