2-BroMo-4-(trifluoroMethyl)thiazole
- Product Name
- 2-BroMo-4-(trifluoroMethyl)thiazole
- CAS No.
- 41731-39-9
- Chemical Name
- 2-BroMo-4-(trifluoroMethyl)thiazole
- Synonyms
- 2-Bromo-4-(trifluoromethyl)thiazol;2-BroMo-4-(trifluoroMethyl)thiazole;Thiazole, 2-broMo-4-(trifluoroMethyl)-;2-bromo-4-(trifluoromethyl)-1,3-thiazole
- CBNumber
- CB22550170
- Molecular Formula
- C4HBrF3NS
- Formula Weight
- 232.02
- MOL File
- 41731-39-9.mol
2-BroMo-4-(trifluoroMethyl)thiazole Property
- Boiling point:
- 182.8±35.0 °C(Predicted)
- Density
- 1.904±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.20±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C4HBrF3NS/c5-3-9-2(1-10-3)4(6,7)8/h1H
- InChIKey
- NZNVGMVYUYNBOM-UHFFFAOYSA-N
- SMILES
- S1C=C(C(F)(F)F)N=C1Br
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B699050
- Product name
- 2-Bromo-4-(trifluoromethyl)thiazole
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 090181
- Product name
- 2-Bromo-4-(trifluoromethyl)thiazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $118
- Updated
- 2021/12/16
- Product number
- FB105725
- Product name
- 2-bromo-4-(trifluoromethyl)-1,3-thiazole
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FB105725
- Product name
- 2-bromo-4-(trifluoromethyl)-1,3-thiazole
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB105725
- Product name
- 2-bromo-4-(trifluoromethyl)-1,3-thiazole
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
2-BroMo-4-(trifluoroMethyl)thiazole Chemical Properties,Usage,Production
Synthesis
349-49-5
41731-39-9
General procedure for the synthesis of 2-bromo-4-(trifluoromethyl)thiazole from 2-amino-4-(trifluoromethyl)thiazole: 2-amino-4-(trifluoromethyl)thiazole (500 mg, purchased from Wako Pure Chemical Industries, Ltd.) was dissolved in a 48% aqueous hydrogen bromide solution (6 mL), and sodium nitrite (266) was added slowly and dropwise, under the cooling of an ice bath. mg) in aqueous sodium nitrite (1 mL) was slowly added dropwise under cooling in an ice bath. The reaction mixture was stirred at 0°C for 1 hour. Subsequently, the reaction was quenched by the addition of aqueous sodium bisulfite, then the pH was adjusted with aqueous sodium hydroxide and finally extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with ethyl acetate-hexane (1:9, v/v) as eluent to give 2-bromo-4-(trifluoromethyl)thiazole (167 mg, 24% yield).1H-NMR (300 MHz, DMSO-d6) δ: 8.55 (s, 1H). Referring to the operation of Example 17 of the starting material synthesis, 1-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine hydrochloride (194 mg, 53% yield) was prepared by the reaction of 2-bromo-4-(trifluoromethyl)thiazole (309 mg) with 1-(tert-butoxycarbonyl)piperazine (300 mg).1H-NMR (300 MHz, DMSO-d6) δ: 3.19-3.24 (m, 4H), 3.66-3.75 (m, 4H), 7.68 (s, 1H), 9.57 (brs, 2H).
References
[1] Patent: EP1714961, 2006, A1. Location in patent: Page/Page column 17
2-BroMo-4-(trifluoroMethyl)thiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BroMo-4-(trifluoroMethyl)thiazole manufacturers
- Product
- 2-BroMo-4-(trifluoroMethyl)thiazole 41731-39-9
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 98%-99%
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-07