ChemicalBook > CAS DataBase List > 2-BROMO-4,6-DIFLUORONITROBENZENE

2-BROMO-4,6-DIFLUORONITROBENZENE

Product Name
2-BROMO-4,6-DIFLUORONITROBENZENE
CAS No.
884494-38-6
Chemical Name
2-BROMO-4,6-DIFLUORONITROBENZENE
Synonyms
2-BROMO-4,6-DIFLUORONITROBENZENE;1-broMo-3,5-difluoro-2-nitrobenzene;Benzene, 1-bromo-3,5-difluoro-2-nitro-;2-BROMO-4,6-DIFLUORONITROBENZENE ISO 9001：2015 REACH
CBNumber
CB5766295
Molecular Formula
C6H2BrF2NO2
Formula Weight
237.99
MOL File
Mol file
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2-BROMO-4,6-DIFLUORONITROBENZENE Property

Boiling point:
226.9±35.0 °C(Predicted)
Density 
1.890±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
crystalline powder
color 
Off-white to faint yellow
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Safety

HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B690308
Product name
2-Bromo-4,6-difluoronitrobenzene
Packaging
250mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-N-00
Product name
2-Bromo-4,6-difluoronitrobenzene
Packaging
5G
Price
$40
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105819
Product name
1-Bromo-3,5-difluoro-2-nitrobenzene
Packaging
10g
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
074450
Product name
2-Bromo-4,6-difluoronitrobenzene
Purity
95+%
Packaging
1g
Price
$98
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105819
Product name
1-Bromo-3,5-difluoro-2-nitrobenzene
Packaging
25g
Price
$100
Updated
2021/12/16
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2-BROMO-4,6-DIFLUORONITROBENZENE Chemical Properties,Usage,Production

Uses

2-Bromo-4,6-difluoronitrobenzene is a polysubstituted fluoronitrobenzene analogue that can be used to prepare pyrazolylamino benzimidazole derivatives as JAK inhibitors.

Synthesis

461-96-1

884494-38-6

Fuming nitric acid (20 mL) was slowly added dropwise to a solution of 1-bromo-3,5-difluorobenzene (35.00 mL, 304 mmol) dissolved in sulfuric acid (50 mL) at 0 °C. The reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction mixture was carefully poured into an ice-water mixture (600 mL) and subsequently slowly warmed to room temperature. Ethyl acetate (200 mL) and hexane (100 mL) were added and stirred until all solids were completely dissolved. The organic layer was separated, washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give 2-bromo-4,6-difluoronitrobenzene as a yellow oil (57.37 g, 79% yield).GCMS analysis showed m/z = 237,239 (corresponding to Br isotope pattern).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5243 - 5263
[2] Patent: US9556153, 2017, B1. Location in patent: Page/Page column 8
[3] Patent: WO2018/13486, 2018, A1. Location in patent: Page/Page column 13

2-BROMO-4,6-DIFLUORONITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-BROMO-4,6-DIFLUORONITROBENZENE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-bromo-3,5-difluoro-2-nitrobenzene 884494-38-6
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-19
Career Henan Chemical Co
Product
2-BROMO-4,6-DIFLUORONITROBENZENE 884494-38-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

884494-38-6, 2-BROMO-4,6-DIFLUORONITROBENZENERelated Search:

2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 2-Bromo-4-nitrobenzaldehyde 2-Bromo-4-methylthiazole 2-Bromo-4-fomylthiazole 2-BROMO-4-(4-BROMO-PHENYL)-THIAZOLE 2-BROMO-5-IODOTHIAZOLE 2-BROMO-4-CYANOTHIAZOLE (2-Bromo-4-nitrophenyl)methanol 2-BROMO-4-METHOXYBENZOTHIAZOLE 2-BROMO-4-METHYLBENZOTHIAZOLE 2-BroMo-4-chloro-3-Methylpyridine 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE 2-Bromo-4-chloro-3-fluoropyridine Benzaldehyde, 2-broMo-4-hydroxy 2-BroMo-4-(trifluoroMethyl)thiazole 2-Bromo-4,5-dimethyl-1,3-thiazole 2-BROMO-4-CHLOROBENZOTHIAZOLE 3-(2-BROMO-THIAZOL-4-YL)-PYRIDINE

  • 1-broMo-3,5-difluoro-2-nitrobenzene
  • 2-BROMO-4,6-DIFLUORONITROBENZENE
  • Benzene, 1-bromo-3,5-difluoro-2-nitro-
  • 2-BROMO-4,6-DIFLUORONITROBENZENE ISO 9001：2015 REACH
  • 884494-38-6