1-BROMO-2,4-DIFLUORO-5-NITROBENZENE

Product Name: 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE
CAS No.: 345-24-4
Chemical Name: 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE
Synonyms: AURORA KA-7912;BUTTPARK 89\07-60;4-DIFLUORO-5-NITROBENZENE;5-BROMO-2,4-DIFLUORONITROBENZENE;2,4-Difluoro-5-BroMonitrobenzene;2,4-Difluoro-5-nitrobroMobenzene;1-BROMO-2,4-DIFLUORO-5-NITROBENZENE;5-Bromo-2,4-difluoronitrobenzene 98%;Benzene, 1-broMo-2,4-difluoro-5-nitro-
CBNumber: CB4776741
Molecular Formula: C6H2BrF2NO2
Formula Weight: 237.99
MOL File: 345-24-4.mol

More

Less

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE Property

Melting point:: 19°C(lit.)
Boiling point:: 85°C 0,4mm
Density: 1.890±0.06 g/cm3(Predicted)
refractive index: 1.5580 to 1.5620
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to lump to clear liquid
color: White or Colorless to Light yellow
InChI: InChI=1S/C6H2BrF2NO2/c7-3-1-6(10(11)12)5(9)2-4(3)8/h1-2H
InChIKey: OOUUWURPSUSDTD-UHFFFAOYSA-N
SMILES: C1(Br)=CC([N+]([O-])=O)=C(F)C=C1F
CAS DataBase Reference: 345-24-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2904990090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: KOB0017
Product name: 1-Bromo-2,4-difluoro-5-nitrobenzene
Packaging: 1 g
Price: $259
Updated: 2025/07/31

TCI Chemical

Product number: B5688
Product name: 1-Bromo-2,4-difluoro-5-nitrobenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: B5688
Product name: 1-Bromo-2,4-difluoro-5-nitrobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $52
Updated: 2025/07/31

TRC

Product number: B690283
Product name: 1-Bromo-2,4-difluoro-5-nitrobenzene
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB82067
Product name: 1-Bromo-2,4-Difluoro-5-Nitrobenzene
Packaging: 10g
Price: $50
Updated: 2021/12/16

More

Less

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE Chemical Properties,Usage,Production

Uses

1-Bromo-2,4-difluoro-5-nitrobenzene is a nitrobenzene derivative containing fluorine and bromine atom substituents. It can be used as a pharmaceutical intermediate for the preparation of novel N2-phenylpyrimidine-2,4-diamine compounds showing effective inhibition of EGFR mutations, and thus can be effectively used in the treatment of EGFR-mutated cancers.

Synthesis

348-57-2

345-24-4

General procedure for the synthesis of 2,4-difluoro-5-bromonitrobenzene from 2,4-difluorobromobenzene: Concentrated HNO3 (34.0 mL) was added slowly and dropwise to a suspension of 1-bromo-2,4-difluorobenzene (53.0 mmol, 6.00 mL) in concentrated H2SO4 (38.5 mL) at 0 °C, ensuring that the internal temperature was maintained below 0 °C. The reaction mixture was stirred for 10 minutes with vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 10 min and subsequently poured into an ice/water mixture under vigorous stirring. The mixture was extracted with ether (ET20, 3 x 100 mL). The combined organic phases were washed sequentially with aqueous NaHCO3 (3 x 100 mL) and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by fast chromatography (eluent: EtOAc/hexane=1:9) to afford 5-bromo-2,4-difluoronitrobenzene as a yellow oil (12.2 g, 97% yield).1H NMR (400 MHz, CDCl3) δ 8.45 (t, 1H, J=7.5 Hz), 7.16 (dd, 1H, J=11.0,8.6 Hz) ; ESMS m/z: 240, 238, 223, 221, 112.

References

[1] Synthesis, 1998, # 8, p. 1101 - 1103
[2] Patent: WO2004/5257, 2004, A1. Location in patent: Page 67
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3870 - 3882
[4] Patent: US2005/154020, 2005, A1. Location in patent: Page/Page column 8
[5] Patent: US2005/154022, 2005, A1. Location in patent: Page/Page column 9

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE Suppliers

Americas 1 Austria 1 China 102 Europe 1 Germany 1 India 2 Japan 1 United Kingdom 11 United States 16 Global 136

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

More

Less

View Lastest Price from 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Bromo-2,4-difluoro-5-nitrobenzene 345-24-4
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-19

Honest Joy Holdings Limited

Product: 1-Bromo-2,4-difluoro-5-nitrobenzene 345-24-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.1%
Supply Ability: 100 tons
Release date: 2022-02-20

Career Henan Chemical Co

Product: 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE 345-24-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

345-24-4, 1-BROMO-2,4-DIFLUORO-5-NITROBENZENERelated Search:

5-Bromo-2,3-difluoro-1-nitrobenzene 1-BROMO-2,5-DIFLUORO-4-NITROBENZENE Nitrobenzene 5-bromo-1,3-difluoro-2-nitrobenzene 3-Bromo-4-fluoroaniline 4-Bromo-1-fluoro-2-nitrobenzene 3-Bromo-4-fluoronitrobenzene 4-Bromofluorobenzene 5-BROMO-2,4-DIFLUOROANILINE 1-Bromo-2,4-difluorobenzene 2,4-Difluoronitrobenzene 5-BROMO-2-FLUOROANILINE 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE 2-BROMO-3,5-DIFLUORO-1-NITROBENZENE 1-BROMO-3,4-DIFLUORO-2-NITROBENZENE 1-BROMO-2,3-DIFLUORO-4-NITROBENZENE 1-BROMO-2,6-DIFLUORO-4-NITROBENZENE 1-BROMO-2,5-DIFLUORO-4-NITROBENZENE, TECH

BUTTPARK 89\07-60

AURORA KA-7912

5-BROMO-2,4-DIFLUORONITROBENZENE

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE

2,4-Difluoro-5-nitrobroMobenzene

2,4-Difluoro-5-BroMonitrobenzene

5-Bromo-2,4-difluoronitrobenzene 98%

Benzene, 1-broMo-2,4-difluoro-5-nitro-

4-DIFLUORO-5-NITROBENZENE

345-24-4

Halides

Phenyls & Phenyl-Het