5-BROMO-2,4-DIFLUOROANILINE

Product Name: 5-BROMO-2,4-DIFLUOROANILINE
CAS No.: 452-92-6
Chemical Name: 5-BROMO-2,4-DIFLUOROANILINE
Synonyms: BUTTPARK 100\01-17;2,4-DIFLUORO-5-BROMOANILINE;3-BROMO-4,6-DIFLUOROANILINE;5-BROMO-2,4-DIFLUOROANILINE;5-Bromo-2,4-difluorobenzenamine;5-Bromo-2,4-difluoroaniline 99%;5-BROMO-2,4-DIFLUORO-PHENYLAMINE;Benzenamine, 5-bromo-2,4-difluoro-;5-BROMO-2,4-DIFLUOROANILINE ISO 9001：2015 REACH
CBNumber: CB9195024
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: 452-92-6.mol

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5-BROMO-2,4-DIFLUOROANILINE Property

Melting point:: 25-29 °C (lit.)
Boiling point:: 223℃
Density: 1.788
Flash point:: >230 °F
storage temp.: 2-8°C
pka: 2.19±0.10(Predicted)
form: solid
Appearance: Off-white to brown Solid
CAS DataBase Reference: 452-92-6(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Toxic/Irritant
HazardClass: IRRITANT
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B677898
Product name: 5-Bromo-2,4-difluoroaniline
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC9925
Product name: 5-Bromo-2,4-difluoroaniline
Purity: 98%
Packaging: 5g
Price: $10
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK221950
Product name: 5-Bromo-2,4-difluoroaniline
Purity: 98%
Packaging: 1g
Price: $22
Updated: 2021/12/16

Apolloscientific

Product number: PC9925
Product name: 5-Bromo-2,4-difluoroaniline
Purity: 98%
Packaging: 25g
Price: $38
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-B-52
Product name: 5-Bromo-2,4-difluoroaniline
Purity: 98%
Packaging: 10g
Price: $39
Updated: 2021/12/16

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5-BROMO-2,4-DIFLUOROANILINE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

5-Bromo-2,4-difluoroaniline is an organic compound commonly used in pharmaceutical research and organic synthesis.

Synthesis

345-24-4

452-92-6

General procedure for the synthesis of 2,4-difluoro-5-bromoaniline from 2,4-difluoro-5-bromonitrobenzene: In a 250 mL round-bottomed flask, 5-bromo-2,4-difluoro nitrobenzene (5.04 g, 21.3 mmol), saturated ammonium chloride solution (25.0 mL), iron powder (5.00 g, 89.5 mmol), ethanol (100 mL), tetrahydrofuran (50.0 mL), and water (25.0 mL), and refluxed at 95 °C for 1.5 hours. Upon completion of the reaction, it was cooled to room temperature, saturated sodium bicarbonate solution (100 mL) was added, and the mixture was filtered through diatomaceous earth and the diatomaceous earth was washed with ethyl acetate (3 x 50 mL). The combined filtrates were washed sequentially with water and brine, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast chromatography (ethyl acetate: hexane = 1:9) to afford 5-bromo-2,4-difluoroaniline (2.61 g, 59.1% yield).1H NMR (400 MHz, CDCl3) δ 6.97 (dd, 1H, J = 7.2, 6.7 Hz), 6.85 (t, 1H, J = 8.2 Hz), 3.63 (br, 2H) .

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3870 - 3882
[2] Patent: WO2004/5257, 2004, A1. Location in patent: Page 67-68
[3] Journal of the American Chemical Society, 1956, vol. 78, p. 2593,2596

5-BROMO-2,4-DIFLUOROANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2,4-DIFLUOROANILINE Suppliers

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View Lastest Price from 5-BROMO-2,4-DIFLUOROANILINE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-2,4-DIFLUOROANILINE 452-92-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-13

452-92-6, 5-BROMO-2,4-DIFLUOROANILINERelated Search:

4-BROMO-3,5-DIFLUOROANILINE,4-Bromo-3,5-difluoroaniline 95% 2-Bromo-3,4-Difluoroaniline 4-Bromo-2,5-difluoroaniline98%,4-Bromo-2,5-difluoroaniline 98%,4-BROMO-2,5-DIFLUOROANILINE 5-BROMO-2,4-DIFLUOROANILINE 3-Bromo-4-fluoroaniline 3-Bromo-4,5-difluoroaniline 98%,3-Bromo-4,5-difluoroaniline98%,3-BROMO-4,5-DIFLUOROANILINE 6-BROMO-2,4-DIFLUOROANILINE,2-Bromo-4,6-difluoroaniline, 99+%,2-Bromo-4,6-difluoroaniline98%,2-Bromo-4,6-difluoroaniline 98%,2-BROMO-4,6-DIFLUOROANILINE 4-BROMO-2,6-DIFLUOROANILINE,4-BROMO-2,6-DIFLUOROANILINE 99% 2,4-Difluoroaniline 3-Bromo-2,6-difluoroaniline 4-Bromo-2,3-difluoroaniline 2-BROMO-4,6-DIFLUOROANILINE HYDROBROMIDE 5-BROMO-2-FLUOROANILINE 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE 2-BROMO-4,5-DIFLUOROANILINE 5-BROMO-2,3-DIFLUOROANILINE 3-Bromo-2,4-difluoroaniline 2-BROMO-2,5-DIFLUOROANILINE

5-BROMO-2,4-DIFLUOROANILINE

3-BROMO-4,6-DIFLUOROANILINE

2,4-DIFLUORO-5-BROMOANILINE

BUTTPARK 100\01-17

5-Bromo-2,4-difluoroaniline 99%

5-BROMO-2,4-DIFLUORO-PHENYLAMINE

Benzenamine, 5-bromo-2,4-difluoro-

5-BROMO-2,4-DIFLUOROANILINE ISO 9001：2015 REACH

5-Bromo-2,4-difluorobenzenamine

452-92-6

C2 to C6

Amines

Building Blocks

Nitrogen Compounds

Organic Building Blocks

Amines

C2 to C6

Other fluorin-contained compounds

Nitrogen Compounds