4-Bromo-3,5-difluoroaniline
- Product Name
- 4-Bromo-3,5-difluoroaniline
- CAS No.
- 203302-95-8
- Chemical Name
- 4-Bromo-3,5-difluoroaniline
- Synonyms
- BUTTPARK 35\03-50;4-BROMO-3,5-DIFLUOROANILINE;4-Bromo-3,5-difluoroaniline >4-Bromo-3,5-difluoroaniline 95%;4-bromo-3,5-difluoro-Benzenamine;Benzenamine, 4-bromo-3,5-difluoro-;4-Bromo-3,5-difluoroaniline ISO 9001：2015 REACH;4-BroMo-3,5-difluoroaniline 95%, 5-difluoroaniline 95%
- CBNumber
- CB8767273
- Molecular Formula
- C6H4BrF2N
- Formula Weight
- 208
- MOL File
- 203302-95-8.mol
4-Bromo-3,5-difluoroaniline Property
- Melting point:
- 99-101°C
- Boiling point:
- 223.7±35.0 °C(Predicted)
- Density
- 1.788±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 1.86±0.10(Predicted)
- color
- White to Light gray to Light orange
- InChI
- InChI=1S/C6H4BrF2N/c7-6-4(8)1-3(10)2-5(6)9/h1-2H,10H2
- InChIKey
- DKKUSFDAHRASGO-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(F)=C(Br)C(F)=C1
- CAS DataBase Reference
- 203302-95-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- RIDADR
- UN2811
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B3416
- Product name
- 4-Bromo-3,5-difluoroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- B3416
- Product name
- 4-Bromo-3,5-difluoroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $247
- Updated
- 2025/07/31
- Product number
- B678980
- Product name
- 4-Bromo-3,5-difluoroaniline
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B678980
- Product name
- 4-Bromo-3,5-difluoroaniline
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 017383
- Product name
- 4-Bromo-3,5-difluoroaniline
- Purity
- 99%
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
4-Bromo-3,5-difluoroaniline Chemical Properties,Usage,Production
Chemical Properties
Pale yellow powder
Uses
4-Bromo-3,5-difluoroaniline is a useful reactant in organic synthesis.
Synthesis
372-39-4
203302-95-8
General procedure for the synthesis of 3,5-difluoro-4-bromoaniline from 3,5-difluoroaniline: 1. 3,5-difluoroaniline (10.0 g, 77.5 mmol) was dissolved in DMF (100 mL), then NBS (13.9 g, 78.0 mmol) was added in batches at room temperature. The reaction mixture was stirred overnight at room temperature and then diluted with Et2O and washed with brine. The organic phase was separated, dried over Na2SO4 and concentrated to give an oil. Purification by column chromatography afforded 4-bromo-3,5-difluoroaniline (i) (12.9 g, 80.2%). 2. A mixture of 4-bromo-3,5-difluoroaniline(i) (6.0 g, 28.8 mmol), ferrous sulfate (1.82 g), glycerol (8.6 mL), nitrobenzene (1.79 mL) and concentrated sulfuric acid (5.0 mL) was gently heated. After the first vigorous reaction, the mixture was boiled for 5 hours. Nitrobenzene was removed by vacuum distillation and the aqueous solution was acidified with glacial acetic acid to isolate a dark brown precipitate. Purification by rapid chromatography (silica gel, petroleum ether/ethyl acetate = 12/1) gave 6-bromo-5,7-difluoroquinoline (ii) as a white solid (3.5 g, 49.8%). 3. To a solution of 6-bromo-5,7-difluoroquinoline(ii) (250 g, 1.02 mol) in anhydrous THF (2200 mL) was added dropwise a hexane solution of n-BuLi (2.5 M, 408 mL, 1.02 mol) at -78 °C. The resulting mixture was stirred at -78 °C for another 30 min. Then, anhydrous THF (200 mL) solution of DMF (79 mL, 1.02 mol) was added while the temperature was kept below -70 °C and the mixture was stirred at the same temperature for 30 min. The reaction mixture was slowly warmed to room temperature and diluted with saturated aqueous NH4Cl solution (1000 mL) and water (800 mL). The mixture was extracted twice with ethyl acetate and the combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give a brown oil. Purification by silica gel column chromatography, eluting with petroleum ether and ethyl acetate (10:1), afforded 5,7-difluoroquinoline-6-carbaldehyde (Intermediate H) as a yellow solid (100 g, 50%). 1H NMR (DMSO, 300 MHz) δ (ppm): 10.38 (s, 1H), 9.10~9.12 (m, 1H), 8.62~8.66 (m, 1H), 7.68~7.78 (m, 2H).
References
[1] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 59-60
[2] Patent: WO2004/48314, 2004, A1. Location in patent: Page 31-32
[3] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0243; 0244; 0245; 0246
4-Bromo-3,5-difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-3,5-difluoroaniline manufacturers
- Product
- 4-Bromo-3,5-difluoroaniline 203302-95-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11