ChemicalBook > CAS DataBase List > 4-Bromo-3,5-difluoroaniline

4-Bromo-3,5-difluoroaniline

Product Name: 4-Bromo-3,5-difluoroaniline
CAS No.: 203302-95-8
Chemical Name: 4-Bromo-3,5-difluoroaniline
Synonyms: BUTTPARK 35\03-50;4-BROMO-3,5-DIFLUOROANILINE;4-Bromo-3,5-difluoroaniline >4-Bromo-3,5-difluoroaniline 95%;4-bromo-3,5-difluoro-Benzenamine;Benzenamine, 4-bromo-3,5-difluoro-;4-Bromo-3,5-difluoroaniline ISO 9001：2015 REACH;4-BroMo-3,5-difluoroaniline 95%, 5-difluoroaniline 95%
CBNumber: CB8767273
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: 203302-95-8.mol

Less

4-Bromo-3,5-difluoroaniline Property

Melting point:: 99-101°C
Boiling point:: 223.7±35.0 °C(Predicted)
Density: 1.788±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 1.86±0.10(Predicted)
color: White to Light gray to Light orange
InChI: InChI=1S/C6H4BrF2N/c7-6-4(8)1-3(10)2-5(6)9/h1-2H,10H2
InChIKey: DKKUSFDAHRASGO-UHFFFAOYSA-N
SMILES: C1(N)=CC(F)=C(Br)C(F)=C1
CAS DataBase Reference: 203302-95-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
RIDADR: UN2811
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 2921420090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3416
Product name: 4-Bromo-3,5-difluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $62
Updated: 2025/07/31

TCI Chemical

Product number: B3416
Product name: 4-Bromo-3,5-difluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $247
Updated: 2025/07/31

TRC

Product number: B678980
Product name: 4-Bromo-3,5-difluoroaniline
Packaging: 5g
Price: $70
Updated: 2021/12/16

TRC

Product number: B678980
Product name: 4-Bromo-3,5-difluoroaniline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-B-43
Product name: 4-Bromo-3,5-difluoroaniline
Purity: 98%
Packaging: 25g
Price: $49
Updated: 2021/12/16

Less

4-Bromo-3,5-difluoroaniline Chemical Properties,Usage,Production

Chemical Properties

Pale yellow powder

Uses

4-Bromo-3,5-difluoroaniline is a useful reactant in organic synthesis.

Synthesis

372-39-4

203302-95-8

General procedure for the synthesis of 3,5-difluoro-4-bromoaniline from 3,5-difluoroaniline: 1. 3,5-difluoroaniline (10.0 g, 77.5 mmol) was dissolved in DMF (100 mL), then NBS (13.9 g, 78.0 mmol) was added in batches at room temperature. The reaction mixture was stirred overnight at room temperature and then diluted with Et2O and washed with brine. The organic phase was separated, dried over Na2SO4 and concentrated to give an oil. Purification by column chromatography afforded 4-bromo-3,5-difluoroaniline (i) (12.9 g, 80.2%). 2. A mixture of 4-bromo-3,5-difluoroaniline(i) (6.0 g, 28.8 mmol), ferrous sulfate (1.82 g), glycerol (8.6 mL), nitrobenzene (1.79 mL) and concentrated sulfuric acid (5.0 mL) was gently heated. After the first vigorous reaction, the mixture was boiled for 5 hours. Nitrobenzene was removed by vacuum distillation and the aqueous solution was acidified with glacial acetic acid to isolate a dark brown precipitate. Purification by rapid chromatography (silica gel, petroleum ether/ethyl acetate = 12/1) gave 6-bromo-5,7-difluoroquinoline (ii) as a white solid (3.5 g, 49.8%). 3. To a solution of 6-bromo-5,7-difluoroquinoline(ii) (250 g, 1.02 mol) in anhydrous THF (2200 mL) was added dropwise a hexane solution of n-BuLi (2.5 M, 408 mL, 1.02 mol) at -78 °C. The resulting mixture was stirred at -78 °C for another 30 min. Then, anhydrous THF (200 mL) solution of DMF (79 mL, 1.02 mol) was added while the temperature was kept below -70 °C and the mixture was stirred at the same temperature for 30 min. The reaction mixture was slowly warmed to room temperature and diluted with saturated aqueous NH4Cl solution (1000 mL) and water (800 mL). The mixture was extracted twice with ethyl acetate and the combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give a brown oil. Purification by silica gel column chromatography, eluting with petroleum ether and ethyl acetate (10:1), afforded 5,7-difluoroquinoline-6-carbaldehyde (Intermediate H) as a yellow solid (100 g, 50%). 1H NMR (DMSO, 300 MHz) δ (ppm): 10.38 (s, 1H), 9.10~9.12 (m, 1H), 8.62~8.66 (m, 1H), 7.68~7.78 (m, 2H).

References

[1] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 59-60
[2] Patent: WO2004/48314, 2004, A1. Location in patent: Page 31-32
[3] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0243; 0244; 0245; 0246

4-Bromo-3,5-difluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-Bromo-3,5-difluoroaniline Suppliers

Americas 1 China 158 Europe 1 France 2 Germany 4 India 7 Italy 1 Japan 1 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 29 Global 225

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Hangzhou Copiore Chemical Co., Ltd.

Tel: 0571-56501939;0571-56076030 13757145729
Fax: 0571-56501939
Email: sales@copiore.com
Country: China
ProdList: 299
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2806
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
Country: China
ProdList: 1542
Advantage: 55

Tianjin Jinyuda Chemical Co., Ltd.

Tel: 022-58013646 13011382049
Fax: 022-23854368
Email: sales@jinyudachem.com
Country: China
ProdList: 1930
Advantage: 55

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Jalor-Chem co.,LTD

Tel: 0510-0510-86396359 13382276200
Email: sales@jalor-chem.com
Country: China
ProdList: 997
Advantage: 56

Nanjing ShengSai Chemical Co., Ltd.

Tel: 025-85205967 13951876367
Fax: 025-85205967
Email: shengsaichem@163.com
Country: China
ProdList: 818
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2788
Advantage: 52

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Suzhou Chenke Biotech Co., Ltd.

Tel: 18662408853
Email: 2120408911@qq.com
Country: China
ProdList: 981
Advantage: 55

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

CHMA Chemical Technology (Shanghai) Co., Ltd

Tel: 021-61556450 15800904410
Fax: 021-61556450
Country: China
ProdList: 2832
Advantage: 58

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Nanjing Ally Chemical S&T Co., Ltd.

Tel: 025-025-58367986 18913956109
Fax: QQ:3209878052
Email: amy.xiang@ally-chem.com
Country: China
ProdList: 568
Advantage: 58

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9942
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Less

View Lastest Price from 4-Bromo-3,5-difluoroaniline manufacturers

Career Henan Chemical Co

Product: 4-Bromo-3,5-difluoroaniline 203302-95-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

203302-95-8, 4-Bromo-3,5-difluoroanilineRelated Search:

4-Aminobenzotrifluoride 2-Aminobenzotrifluoride 4-Fluoroaniline 4-(Trifluoromethoxy)aniline 3-Bromoaniline 2,5-Difluoroaniline 4-Bromoaniline 2-Fluoroaniline 3,5-Difluoroaniline Ethyl bromodifluoroacetate Bromine 3-Bromo-4,5-difluoroaniline98%,3-Bromo-4,5-difluoroaniline 98%,3-BROMO-4,5-DIFLUOROANILINE 2-Bromo-4,6-difluoroaniline98%,2-Bromo-4,6-difluoroaniline 98%,2-BROMO-4,6-DIFLUOROANILINE,2-Bromo-4,6-difluoroaniline, 99+%,6-BROMO-2,4-DIFLUOROANILINE 4-BROMO-2,6-DIFLUOROANILINE,4-BROMO-2,6-DIFLUOROANILINE 99% 3-BROMO-4,6-DIFLUOROANILINE,5-BROMO-2,4-DIFLUOROANILINE 2-Bromo-3,4-Difluoroaniline 3-Bromo-2,6-difluoroaniline 4-Bromo-2,5-difluoroaniline98%,4-Bromo-2,5-difluoroaniline 98%,4-BROMO-2,5-DIFLUOROANILINE

4-BROMO-3,5-DIFLUOROANILINE

BUTTPARK 35\03-50

4-bromo-3,5-difluoro-Benzenamine

4-Bromo-3,5-difluoroaniline 95%

4-BroMo-3,5-difluoroaniline 95%, 5-difluoroaniline 95%

Benzenamine, 4-bromo-3,5-difluoro-

4-Bromo-3,5-difluoroaniline &gt

4-Bromo-3,5-difluoroaniline ISO 9001：2015 REACH

203302-95-8

203303-95-8

Anilines, Aromatic Amines and Nitro Compounds

Aniline