4-Bromo-2,6-difluoroaniline
- Product Name
- 4-Bromo-2,6-difluoroaniline
- CAS No.
- 67567-26-4
- Chemical Name
- 4-Bromo-2,6-difluoroaniline
- Synonyms
- BUTTPARK 22\07-66;Abesili impurity 10;4-Bromo-2,6-difluoro;Vandetanib Impurity 8;4-Bromo-2, 6-difluoroan;2,6-difluro-4-broMoaniline;4-Bromo-2,6-diflaoroaniline;4-BROMO-2,6-DIFLUOROANILINE;2,6-DIFLUORO-4-BROMOANILINE;BFQSQUAVMNHOEF-UHFFFAOYSA-N
- CBNumber
- CB4249197
- Molecular Formula
- C6H4BrF2N
- Formula Weight
- 208
- MOL File
- 67567-26-4.mol
4-Bromo-2,6-difluoroaniline Property
- Melting point:
- 63-65 °C (lit.)
- Boiling point:
- 188.2±35.0 °C(Predicted)
- Density
- 1.788±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 1.11±0.10(Predicted)
- form
- Crystalline Powder
- color
- Brown
- InChI
- InChI=1S/C6H4BrF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
- InChIKey
- BFQSQUAVMNHOEF-UHFFFAOYSA-N
- SMILES
- C1(N)=C(F)C=C(Br)C=C1F
- CAS DataBase Reference
- 67567-26-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-36/37/39-22
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 327867
- Product name
- 4-Bromo-2,6-difluoroaniline
- Purity
- 98%
- Packaging
- 5g
- Price
- $93.8
- Updated
- 2025/07/31
- Product number
- B3220
- Product name
- 4-Bromo-2,6-difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $65
- Updated
- 2025/07/31
- Product number
- B3220
- Product name
- 4-Bromo-2,6-difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $159
- Updated
- 2025/07/31
- Product number
- B3220
- Product name
- 4-Bromo-2,6-difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $536
- Updated
- 2025/07/31
- Product number
- B683430
- Product name
- 4-Bromo-2,6-difluoroaniline
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
4-Bromo-2,6-difluoroaniline Chemical Properties,Usage,Production
Chemical Properties
Off-white crystalline
Uses
4-Bromo-2,6-difluoroaniline was used in synthesis of:
- ammonium 5-bromo-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate, fluorogenic derivatizating reagent for the determination of aminothiols by HPLC
- olefin tolanes
- 1-(4-amino-3,5-difluoro)-2-(4-butyloxyphenyl)ethyne
- 4′′-n-butyloxy-3,5-difluoroterphenyl-4-amine
- 4-(3-methylbut-1-yn-3-ol)-2,6-difluoroaniline
Uses
4-Bromo-2,6-difluoroaniline is used in the preparation of potent, VEGF receptor tyrosine kinase inhibitors.
Synthesis
5509-65-9
67567-26-4
b) Preparation of Intermediate 2: Dissolve 2,6-difluoroaniline (3.0 g, 22.56 mmol) in acetic acid (10 mL). Bromine (1.2 mL) was slowly added dropwise to the above solution. The reaction mixture was stirred at room temperature for 15 minutes. After the reaction was completed, the solvent was evaporated under reduced pressure. The residue was neutralized with aqueous sodium carbonate and the aqueous phase was subsequently extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give Intermediate 2 in 92% yield.
References
[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 4, p. 1544 - 1547
[2] Angew. Chem., 2016, vol. 128, # 4, p. 1569 - 1573,5
[3] Journal of Materials Chemistry C, 2016, vol. 4, # 23, p. 5326 - 5333
[4] Patent: WO2006/15985, 2006, A1. Location in patent: Page/Page column 54
[5] Patent: US6716491, 2004, B2
4-Bromo-2,6-difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2,6-difluoroaniline manufacturers
- Product
- 4-bromo-2,6-difluoro-phenylamine 67567-26-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 4-Bromo-2,6-difluoroaniline 67567-26-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 4-Bromo-2,6-difluoroaniline 67567-26-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-12