4-BROMO-2,5-DIFLUOROANILINE
- Product Name
- 4-BROMO-2,5-DIFLUOROANILINE
- CAS No.
- 112279-60-4
- Chemical Name
- 4-BROMO-2,5-DIFLUOROANILINE
- Synonyms
- 4-BROMO-2,5-DIFLUOROANILINE;2,5-Difluoro-4-bromoaniline;4-Bromo-2,5-difluoroaniline98%;4-Bromo-2,5-difluoroaniline >4-broMo-2,5-difluorobenzenaMine;4-Bromo-2,5-difluoroaniline 98%;4-Bromo-2,5-difluoro-phenylamine;Benzenamine, 4-bromo-2,5-difluoro-;4-BROMO-2,5-DIFLUOROANILINE ISO 9001：2015 REACH;4-bromo-2,5-difluorophenylamine,4-BroMo-2,5-difluoroaniline,4-Amino-2,5-difluorobromobenzene,4-Bromo-2,5-difluorobenzenamine
- CBNumber
- CB9242885
- Molecular Formula
- C6H4BrF2N
- Formula Weight
- 208
- MOL File
- 112279-60-4.mol
4-BROMO-2,5-DIFLUOROANILINE Property
- Melting point:
- 74-78 °C (lit.)
- Boiling point:
- 212.1±35.0 °C(Predicted)
- Density
- 1.788±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 1.48±0.10(Predicted)
- color
- White to Light yellow
- BRN
- 4741102
- InChI
- InChI=1S/C6H4BrF2N/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,10H2
- InChIKey
- XOYHFIQPPOJMFK-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(F)=C(Br)C=C1F
- CAS DataBase Reference
- 112279-60-4(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38
- Safety Statements
- 28-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 638412
- Product name
- 4-Bromo-2,5-difluoroaniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $64.3
- Updated
- 2025/07/31
- Product number
- 638412
- Product name
- 4-Bromo-2,5-difluoroaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $35
- Updated
- 2023/06/20
- Product number
- B2072
- Product name
- 4-Bromo-2,5-difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- B2072
- Product name
- 4-Bromo-2,5-difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- B699578
- Product name
- 4-Bromo-2,5-difluoroaniline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
4-BROMO-2,5-DIFLUOROANILINE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
367-30-6
112279-60-4
Example 14 Preparation of 4-bromo-2,5-difluoroaniline: To a stirred mixture of 100 g of 2,5-difluoroaniline and 1150 mL of acetic acid (AcOH) was slowly added 40.2 mL of bromine (Br2) in 350 mL of acetic acid (AcOH) over a period of 1.3 h. The reaction temperature was maintained at a temperature of between 15 °C and 20 °C. The reaction was carried out over a period of 2.3 hours. Upon completion of the reaction, the resulting pink suspension was continued to be stirred for 30 minutes, followed by vacuum evaporation to remove the solvent. The residue was alkalized with 50% sodium hydroxide (NaOH) solution (ice was added during the process to maintain the temperature below 35°C). The free base was extracted with 1 L of dichloromethane (CH2Cl2), and the extract was washed with 2 x 100 mL of water (H2O), dried over anhydrous sodium sulfate (Na2SO4), and finally the solvent was evaporated under vacuum to afford 157 g (97.5% yield) of the target product 4-bromo-2,5-difluoroaniline, with melting points ranging from 73°C to 75°C. Mass spectrometry analysis showed the M+1 ion peaks at 208 and 210.
References
[1] Patent: EP224001, 1991, B1
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 43 - 64
[3] Journal of Materials Chemistry, 2004, vol. 14, # 11, p. 1731 - 1743
[4] Patent: EP329752, 1989, A1
[5] Patent: WO2013/142266, 2013, A1. Location in patent: Paragraph 00498
4-BROMO-2,5-DIFLUOROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-2,5-DIFLUOROANILINE manufacturers
- Product
- 4-BROMO-2,5-DIFLUOROANILINE 112279-60-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-08-26
- Product
- 4-BROMO-2,5-DIFLUOROANILINE 112279-60-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- 4-BROMO-2,5-DIFLUOROANILINE 112279-60-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11