2,5-Difluoroaniline
- Product Name
- 2,5-Difluoroaniline
- CAS No.
- 367-30-6
- Chemical Name
- 2,5-Difluoroaniline
- Synonyms
- 2,5-DIFLUOROBENZENAMINE;Difluoroaniline3;2,5-Difluoranilin;2,5-DIFLUOROANILINE;Aniline, 2,5-difluoro-;2,5-Difluoroaniline,98%;2,5-Difluoroaniline 98%;2,5-Difluoroaniline,99%;2,5-Difluoroaniline >2,5-Difluoro-phenylamine
- CBNumber
- CB6299323
- Molecular Formula
- C6H5F2N
- Formula Weight
- 129.11
- MOL File
- 367-30-6.mol
2,5-Difluoroaniline Property
- Melting point:
- 11-13 °C (lit.)
- Boiling point:
- 176-178 °C (lit.)
- Density
- 1.288 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.513(lit.)
- Flash point:
- 156 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.19±0.10(Predicted)
- form
- clear liquid
- color
- Colorless to Yellow to Orange
- Specific Gravity
- 1.29
- Water Solubility
- Not miscible in water.
- BRN
- 2802549
- InChI
- InChI=1S/C6H5F2N/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
- InChIKey
- YNOOQIUSYGWMSS-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(F)=CC=C1F
- CAS DataBase Reference
- 367-30-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, 2,5-difluoro-(367-30-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 28-36/37/39-26-36
- RIDADR
- 2941
- WGK Germany
- 3
- F
- 8-10-23
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214210
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 196606
- Product name
- 2,5-Difluoroaniline
- Purity
- 99.5%
- Packaging
- 25g
- Price
- $33.15
- Updated
- 2025/07/31
- Product number
- 196606
- Product name
- 2,5-Difluoroaniline
- Purity
- 99.5%
- Packaging
- 5g
- Price
- $27
- Updated
- 2023/06/20
- Product number
- D1634
- Product name
- 2,5-Difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- D1634
- Product name
- 2,5-Difluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- D442320
- Product name
- 2,5-Difluoroaniline
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
2,5-Difluoroaniline Chemical Properties,Usage,Production
Chemical Properties
clear brown liquid
Uses
2,5-Difluoroaniline was used in the synthesis of 2,4-di-tert-butyl-6-[(2,5-difluorophenyl)iminomethyl]phenol. It was also used in ultrasound-assisted preparation of 1,4-diazabutadienes. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
Synthesis
364-74-9
367-30-6
General procedure for the synthesis of 2,5-difluoroaniline from 2,5-difluoronitrobenzene: To a solution of 1,4-difluoro-2-nitrobenzene (500 mg, 3.14 mmol) in methanol (20 mL) was added palladium/carbon catalyst (66.9 mg, 0.629 mmol) in batches. Subsequently, the reaction mixture was stirred at 20 °C for 1 h under hydrogen atmosphere. The reaction progress was monitored by thin layer chromatography (TLC, petroleum ether/ethyl acetate = 3/1) and after confirming the complete consumption of raw materials, the reaction mixture was filtered. The filtrate was concentrated to afford the target product 2,5-difluoroaniline (338 mg, 2.61 mmol, 83% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.94-6.88 (m, 1H), 6.50-6.46 (m, 1H), 6.40-6.31 (m, 1H), 3.82 (br.s., 2H).
References
[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0485; 0486
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 109
[3] Recueil des Travaux Chimiques des Pays-Bas, 1914, vol. 33, p. 299
[4] Chem. Zentralbl., 1914, vol. 85, # II, p. 320
[5] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111
2,5-Difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Difluoroaniline manufacturers
- Product
- 2,5-Difluoroaniline 367-30-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-18
- Product
- 2,5-Difluoroaniline 367-30-6
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
- Product
- 2,5-Difluoroaniline 367-30-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18