ChemicalBook > CAS DataBase List > 2,5-Difluoroaniline

2,5-Difluoroaniline

Product Name
2,5-Difluoroaniline
CAS No.
367-30-6
Chemical Name
2,5-Difluoroaniline
Synonyms
2,5-DIFLUOROBENZENAMINE;Difluoroaniline3;2,5-Difluoranilin;2,5-DIFLUOROANILINE;Aniline, 2,5-difluoro-;2,5-Difluoroaniline,98%;2,5-Difluoroaniline 98%;2,5-Difluoroaniline,99%;2,5-Difluoroaniline >2,5-Difluoro-phenylamine
CBNumber
CB6299323
Molecular Formula
C6H5F2N
Formula Weight
129.11
MOL File
367-30-6.mol
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2,5-Difluoroaniline Property

Melting point:
11-13 °C (lit.)
Boiling point:
176-178 °C (lit.)
Density 
1.288 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.513(lit.)
Flash point:
156 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
2.19±0.10(Predicted)
form 
clear liquid
color 
Colorless to Yellow to Orange
Specific Gravity
1.29
Water Solubility 
Not miscible in water.
BRN 
2802549
InChI
InChI=1S/C6H5F2N/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
InChIKey
YNOOQIUSYGWMSS-UHFFFAOYSA-N
SMILES
C1(N)=CC(F)=CC=C1F
CAS DataBase Reference
367-30-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2,5-difluoro-(367-30-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
28-36/37/39-26-36
RIDADR 
2941
WGK Germany 
3
F 
8-10-23
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
196606
Product name
2,5-Difluoroaniline
Purity
99.5%
Packaging
25g
Price
$33.15
Updated
2025/07/31
Sigma-Aldrich
Product number
196606
Product name
2,5-Difluoroaniline
Purity
99.5%
Packaging
5g
Price
$27
Updated
2023/06/20
TCI Chemical
Product number
D1634
Product name
2,5-Difluoroaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
D1634
Product name
2,5-Difluoroaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$118
Updated
2025/07/31
TRC
Product number
D442320
Product name
2,5-Difluoroaniline
Packaging
1g
Price
$55
Updated
2021/12/16
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2,5-Difluoroaniline Chemical Properties,Usage,Production

Chemical Properties

clear brown liquid

Uses

2,5-Difluoroaniline was used in the synthesis of 2,4-di-tert-butyl-6-[(2,5-difluorophenyl)iminomethyl]phenol. It was also used in ultrasound-assisted preparation of 1,4-diazabutadienes. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.

Synthesis

364-74-9

367-30-6

General procedure for the synthesis of 2,5-difluoroaniline from 2,5-difluoronitrobenzene: To a solution of 1,4-difluoro-2-nitrobenzene (500 mg, 3.14 mmol) in methanol (20 mL) was added palladium/carbon catalyst (66.9 mg, 0.629 mmol) in batches. Subsequently, the reaction mixture was stirred at 20 °C for 1 h under hydrogen atmosphere. The reaction progress was monitored by thin layer chromatography (TLC, petroleum ether/ethyl acetate = 3/1) and after confirming the complete consumption of raw materials, the reaction mixture was filtered. The filtrate was concentrated to afford the target product 2,5-difluoroaniline (338 mg, 2.61 mmol, 83% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.94-6.88 (m, 1H), 6.50-6.46 (m, 1H), 6.40-6.31 (m, 1H), 3.82 (br.s., 2H).

References

[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0485; 0486
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 109
[3] Recueil des Travaux Chimiques des Pays-Bas, 1914, vol. 33, p. 299
[4] Chem. Zentralbl., 1914, vol. 85, # II, p. 320
[5] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111

2,5-Difluoroaniline Preparation Products And Raw materials

Raw materials

1,4-Difluorobenzene Nitric acid Iron

Preparation Products

4-BROMO-2,5-DIFLUOROBENZENESULFONYL CHLORIDE
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View Lastest Price from 2,5-Difluoroaniline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,5-Difluoroaniline 367-30-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-06-18
Henan Fengda Chemical Co., Ltd
Product
2,5-Difluoroaniline 367-30-6
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Honest Joy Holdings Limited
Product
2,5-Difluoroaniline 367-30-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99.3%
Supply Ability
100 tons
Release date
2022-02-18

367-30-6, 2,5-DifluoroanilineRelated Search:

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  • 367-30-6
  • Amines
  • Building Blocks
  • C2 to C6
  • Organic Building Blocks
  • Nitrogen Compounds
  • Anilines, Aromatic Amines and Nitro Compounds
  • Aniline
  • Fluorobenzene
  • Miscellaneous
  • Amines
  • C2 to C6
  • Nitrogen Compounds
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