3,4-Difluoroaniline

Product Name: 3,4-Difluoroaniline
CAS No.: 3863-11-4
Chemical Name: 3,4-Difluoroaniline
Synonyms: 3,4-DIFLUOROBENZENAMINE;3,4-Difluoro-phenylamine;AKOS 91142;3,4-DIFLUOROANILINE;TIMTEC-BB SBB007915;3, 4-2 fluoro aniline;Linezolid Impurity 95;3,4-Difluoroaniline98%;3,4-Difluoroaniline>3,4-difluoro-benzenamin
CBNumber: CB1398032
Molecular Formula: C6H5F2N
Formula Weight: 129.11
MOL File: 3863-11-4.mol

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3,4-Difluoroaniline Property

Melting point:: 22°C
Boiling point:: 77 °C/7 mmHg (lit.)
Density: 1.302 g/mL at 25 °C (lit.)
refractive index: n20/D 1.513(lit.)
Flash point:: 185 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to lump to clear liquid
pka: 3?+-.0.10(Predicted)
Specific Gravity: 1.302
color: White or Colorless to Yellow
Water Solubility: SLIGHTLY SOLUBLE
BRN: 971235
InChI: InChI=1S/C6H5F2N/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
InChIKey: AXNUZKSSQHTNPZ-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(F)C(F)=C1
CAS DataBase Reference: 3863-11-4(CAS DataBase Reference)
NIST Chemistry Reference: 3,4-Difluoroaniline(3863-11-4)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
RIDADR: UN 2941 6.1/PG 3
WGK Germany: 3
RTECS: CX9871900
F: 8-10-23
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 270237
Product name: 3,4-Difluoroaniline
Purity: 99%
Packaging: 5g
Price: $50.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 270237
Product name: 3,4-Difluoroaniline
Purity: 99%
Packaging: 25g
Price: $91.77
Updated: 2025/07/31

TCI Chemical

Product number: D1809
Product name: 3,4-Difluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $92
Updated: 2025/07/31

TCI Chemical

Product number: D1809
Product name: 3,4-Difluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 100g
Price: $276
Updated: 2025/07/31

TRC

Product number: D445340
Product name: 3,4-Difluoroaniline
Packaging: 5g
Price: $50
Updated: 2021/12/16

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3,4-Difluoroaniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow to straw liquid after melting

Uses

3,4-Difluoroaniline was used in the synthesis of (3,4-disfluoro)phenylquione.

General Description

3,4-Difluoroaniline (3,4-DFA) was degraded, under aerobic conditions, by Pseudomonas fluorescens.

Synthesis

369-34-6

3863-11-4

The general procedure for the synthesis of 3,4-difluoroaniline from 3,4-difluoronitrobenzene was as follows: 200.0 g of 3,4-difluoronitrobenzene, 600.0 mL of toluene and 12.0 g of Pd/C catalyst were added to an autoclave at 25 °C to 35 °C. Hydrogen was passed into the reaction system, keeping the hydrogen pressure between 2.0 and 6.0 kg/cm2, and the reaction was carried out at 25 °C to 35 °C for 3 to 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) to ensure complete reaction. Upon completion of the reaction, the reaction mixture was sequentially depressurized and unloaded, filtered through a Hyflow bed, and the filter cake was washed with 200.0 mL of toluene. The filtrate was collected and vacuum distilled at less than 50 °C to remove the solvent. Finally, 152.0 g of crude 3,4-difluoroaniline was obtained in 93.8% yield and 95.85% purity by high performance liquid chromatography (HPLC).

References

[1] Patent: WO2015/68171, 2015, A1. Location in patent: Page/Page column 9; 16
[2] Tetrahedron Letters, 2010, vol. 51, # 5, p. 786 - 789
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 2, p. 613 - 617
[4] ChemPlusChem, 2018, vol. 83, # 5, p. 375 - 382
[5] Synthesis, 2001, # 1, p. 81 - 84

3,4-Difluoroaniline Preparation Products And Raw materials

Raw materials

Iron

Preparation Products

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3,4-Difluoroaniline Suppliers

Americas 1 Belgium 1 Canada 1 China 312 Europe 4 France 1 Germany 7 India 6 Italy 1 Japan 4 Jordan 1 Russia 1 Slovakia 1 Switzerland 1 Ukraine 2 United Kingdom 18 United States 40 Global 402

Zhejiang Xieshi New Materials Co., Ltd.,

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

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Capot Chemical Co., Ltd

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View Lastest Price from 3,4-Difluoroaniline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3,4-Difluoroaniline 3863-11-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-30

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3,4-Difluoroaniline 3863-11-4
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

Shaanxi Dideu Medichem Co. Ltd

Product: 3,4-Difluoroaniline 3863-11-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-14

3863-11-4, 3,4-DifluoroanilineRelated Search:

3-Aminobenzotrifluoride Sodium diphenylamine-4-sulfonate 3-Fluoroaniline 4-(Trifluoromethoxy)aniline N,N-Dimethyl-1,4-phenylenediamine 2-Fluoroaniline Diphenylamine 4-Fluoroaniline N,N-Dimethylaniline 2,3,4-Trifluorobenzenamine 2,3,4,5,6-Pentafluoroaniline 2-BROMO-4,5,6-TRIFLUOROANILINE N,N'-BIS(PENTAFLUOROPHENYL)UREA 2,4,5-Trifluoroaniline 2,4,5-TRIFLUORO-6-BROMOANILINE 3,4-Difluoronitrobenzene 2,3-DIFLUOROANILINE 2,5-Difluoroaniline

3,4-Difluoroaniline, 99+% 2.5ML

Linezolid Aniline Impurity

Linezolid Impurity 95

3,4-Difluoroaniline 98%, 4-Difluoroaniline 98%

3, 4-2 fluoro aniline

TIMTEC-BB SBB007915

3,4-DIFLUOROANILINE

3,4-DIFLUOROBENZENAMINE

3,4-difluoro-benzenamin

Benzenamine, 3,4-difluoro-

3,4-Difluoro-phenylamine

AKOS 91142

3,4-Difluoroaniline, 99+%

3,4-Difluoroaniline 98%

3,4-Difluoroaniline98%

3,4-Difluoroaniline&gt

Gefitinib Impurity 35 (3,4-Difluoroaniline)

3,4-Difluoroaniline ISO 9001：2015 REACH

3,4-Difluoroaniline (Gefitinib Impurity)

high quality 3,4-Difluoroaniline

3863-11-4

11/4/3863

717280

3683-11-4

717-28-0

3843-11-4

Amines

Building Blocks

C2 to C6

Nitrogen Compounds

Organic Building Blocks

Nitrogen Compounds

Amines

C2 to C6

Anilines, Amides & Amines

Fluorine Compounds

Anilines, Aromatic Amines and Nitro Compounds

Fluorobenzene Series

Fluorine series

bc0001