2,3-Difluoroaniline
- Product Name
- 2,3-Difluoroaniline
- CAS No.
- 4519-40-8
- Chemical Name
- 2,3-Difluoroaniline
- Synonyms
- 2,3-Difluorobenzenamine;2,3-DIFLUOROANILINE;TIMTEC-BB SBB006565;2,3-Difluoroaniline>2,3- twofluoro aniline;2,3-difluorophenylamine;2,3-Difluoroaniline,98%;2,3-Difluoroaniline 98%;Benzenamine, 2,3-difluoro-;2,3-Difluoroaniline, 98% 1GR
- CBNumber
- CB8453088
- Molecular Formula
- C6H5F2N
- Formula Weight
- 129.11
- MOL File
- 4519-40-8.mol
2,3-Difluoroaniline Property
- Boiling point:
- 68-69 °C
- Density
- 1.274 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.514(lit.)
- Flash point:
- 160 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.19±0.10(Predicted)
- form
- Liquid
- Specific Gravity
- 1.274
- color
- Clear light orange
- BRN
- 2716500
- InChI
- InChI=1S/C6H5F2N/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
- InChIKey
- YCCQGFYAVUTQFK-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(F)=C1F
- CAS DataBase Reference
- 4519-40-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-27-28-36/37/39-36
- RIDADR
- 2941
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 265306
- Product name
- 2,3-Difluoroaniline
- Purity
- 98%
- Packaging
- 5g
- Price
- $66.4
- Updated
- 2025/07/31
- Product number
- D2595
- Product name
- 2,3-Difluoroaniline
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- D2595
- Product name
- 2,3-Difluoroaniline
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- D445510
- Product name
- 2,3-Difluoroaniline
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D445510
- Product name
- 2,3-Difluoroaniline
- Packaging
- 5g
- Price
- $105
- Updated
- 2021/12/16
2,3-Difluoroaniline Chemical Properties,Usage,Production
Chemical Properties
clear light orange liquid
Uses
2,3-Difluoroaniline was used in the synthesis of ethyl 2-arylamino-4-trifluoromethylpyrimidine-5-carboxylate.
Uses
intermediate for liquid crystal and drugs
Synthesis
1481-57-8
4519-40-8
The general procedure for the synthesis of 2,3-difluoroaniline from 2,3-dibromo-5,6-difluoronitrobenzene was as follows: first, 0.638 g (2.01 mmol) of 2,3-dibromo-5,6-difluoronitrobenzene was dissolved in 4 mL of methanol. Subsequently, 48.4 mg of 10% Pd/C (50% wet) catalyst and 6.2 mg (0.06 mmol) of triethylamine were added to the solution. The atmosphere in the reaction vessel was replaced with hydrogen and the reaction mixture was stirred at 50 °C for 2 h under slight hydrogen pressure. The reaction mixture was analyzed by HPLC, which showed the presence of 2.2 area% of 2,3-dibromo-5,6-difluoroaniline as a residual intermediate. The reaction was continued under the same conditions for 0.5 hours. After completion of the reaction, the catalyst was removed by filtration. The resulting liquid was quantitatively analyzed by HPLC and the yield of 2,3-difluoroaniline was measured to be 93% and the intermediate 2,3-dibromo-5,6-difluoroaniline was completely consumed.
References
[1] Patent: EP2940002, 2015, A1. Location in patent: Paragraph 0075
2,3-Difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Difluoroaniline manufacturers
- Product
- 2,3-Difluoroaniline 4519-40-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2,3-Difluoroaniline 4519-40-8
- Price
- US $10.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-01
- Product
- 2,3-Difluoroaniline 4519-40-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09