3-Bromo-2,4-difluoroaniline
- Product Name
- 3-Bromo-2,4-difluoroaniline
- CAS No.
- 103977-79-3
- Chemical Name
- 3-Bromo-2,4-difluoroaniline
- Synonyms
- 3-Bromo-2,4-difluoroaniline;3-Bromo-2,4-difluorophenylamine;3-Amino-2,6-difluorobromobenzene;BenzenaMine, 3-broMo-2,4-difluoro-;2-bromo-1,3-difluoro-4-aminobenzene;Hexanoicacid,5-methyl-6-oxo-,ethylester
- CBNumber
- CB8970154
- Molecular Formula
- C6H4BrF2N
- Formula Weight
- 208
- MOL File
- Mol file
3-Bromo-2,4-difluoroaniline Property
- Boiling point:
- 224.8±35.0 °C(Predicted)
- Density
- 1.788±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.19±0.10(Predicted)
- form
- crystalline solid
- color
- Grey to faint purple
Safety
- HS Code
- 2921420090
N-Bromosuccinimide Price
- Product number
- B997320
- Product name
- 3-Bromo-2,4-difluoroaniline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0127903
- Product name
- 3-Bromo-2,4-difluoroaniline
- Purity
- 99.56%
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC49009
- Product name
- 3-Bromo-2,4-difluoroaniline
- Packaging
- 5g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 3630-B-06
- Product name
- 3-Bromo-2,4-difluoroaniline
- Packaging
- 5G
- Price
- $80
- Updated
- 2021/12/16
- Product number
- Z6709
- Product name
- 3-Bromo-2,4-difluoroaniline
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
3-Bromo-2,4-difluoroaniline Chemical Properties,Usage,Production
Uses
3-Bromo-2,4-difluoroaniline is a fluoroaniline compound that is used in the preparation of pharmaceutical chemicals.
Synthesis
103977-78-2
103977-79-3
General procedure for the synthesis of 2,4-difluoro-3-bromoaniline from 2-bromo-1,3-difluoro-4-nitrobenzene: A mixture of 2-bromo-1,3-difluoro-4-nitrobenzene (30 g, 130 mmol) and tin (II) chloride dihydrate in 36% hydrochloric acid (150 ml) was heated to 40 °C. Ether (20 ml) was added slowly to form a homogeneous solution. The reaction then proceeded rapidly, accompanied by boiling of the ether. After continued heating at 60°C for 1 hour, the reaction mixture was cooled and subsequently poured into ice water (1.5 liters). The pH of the mixture was adjusted to 13 with a 30% aqueous sodium hydroxide solution, while the internal temperature was controlled below 20°C. The resulting gray slurry was vortex-extracted with chloroform (2 x 500 ml), the organic phases were combined, washed with water and subsequently dried over anhydrous magnesium sulfate containing 2 g of decolorized carbon. After filtration, the solvent was removed by evaporation to give the crude product. Grinding of the crude product with isohexane afforded 23 g (83% yield) of 2,4-difluoro-3-bromoaniline as a light yellow solid. The product was characterized by 1H NMR (360 MHz, CDCl3): δ 3.51 (2H, br), 6.65-6.70 (1H, m), 6.75-6.80 (1H, m).
References
[1] Patent: WO2003/93272, 2003, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5927 - 5932
[3] Patent: CN108117553, 2018, A. Location in patent: Paragraph 0105; 0106; 0122-0124
[4] Tetrahedron Letters, 2010, vol. 51, # 4, p. 600 - 601
[5] Patent: WO2015/54572, 2015, A1. Location in patent: Page/Page column 279
3-Bromo-2,4-difluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-2,4-difluoroaniline manufacturers
- Product
- 3-Bromo-2,4-difluoroaniline 103977-79-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 200KG
- Release date
- 2020-01-07