ChemicalBook > CAS DataBase List > 3-Bromo-2,4-difluoroaniline

3-Bromo-2,4-difluoroaniline

Product Name: 3-Bromo-2,4-difluoroaniline
CAS No.: 103977-79-3
Chemical Name: 3-Bromo-2,4-difluoroaniline
Synonyms: 3-Bromo-2,4-difluoroaniline;3-Bromo-2,4-difluorophenylamine;3-Amino-2,6-difluorobromobenzene;BenzenaMine, 3-broMo-2,4-difluoro-;2-bromo-1,3-difluoro-4-aminobenzene;Hexanoicacid,5-methyl-6-oxo-,ethylester
CBNumber: CB8970154
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: Mol file

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3-Bromo-2,4-difluoroaniline Property

Boiling point:: 224.8±35.0 °C(Predicted)
Density: 1.788±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.19±0.10(Predicted)
form: crystalline solid
color: Grey to faint purple

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Safety

HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B997320
Product name: 3-Bromo-2,4-difluoroaniline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC49009
Product name: 3-Bromo-2,4-difluoroaniline
Packaging: 1g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-B-06
Product name: 3-Bromo-2,4-difluoroaniline
Packaging: 1g
Price: $36
Updated: 2021/12/16

ChemScene

Product number: CS-0127903
Product name: 3-Bromo-2,4-difluoroaniline
Purity: 99.56%
Packaging: 5g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC49009
Product name: 3-Bromo-2,4-difluoroaniline
Packaging: 5g
Price: $68
Updated: 2021/12/16

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3-Bromo-2,4-difluoroaniline Chemical Properties,Usage,Production

Uses

3-Bromo-2,4-difluoroaniline is a fluoroaniline compound that is used in the preparation of pharmaceutical chemicals.

Synthesis

103977-78-2

103977-79-3

General procedure for the synthesis of 2,4-difluoro-3-bromoaniline from 2-bromo-1,3-difluoro-4-nitrobenzene: A mixture of 2-bromo-1,3-difluoro-4-nitrobenzene (30 g, 130 mmol) and tin (II) chloride dihydrate in 36% hydrochloric acid (150 ml) was heated to 40 °C. Ether (20 ml) was added slowly to form a homogeneous solution. The reaction then proceeded rapidly, accompanied by boiling of the ether. After continued heating at 60°C for 1 hour, the reaction mixture was cooled and subsequently poured into ice water (1.5 liters). The pH of the mixture was adjusted to 13 with a 30% aqueous sodium hydroxide solution, while the internal temperature was controlled below 20°C. The resulting gray slurry was vortex-extracted with chloroform (2 x 500 ml), the organic phases were combined, washed with water and subsequently dried over anhydrous magnesium sulfate containing 2 g of decolorized carbon. After filtration, the solvent was removed by evaporation to give the crude product. Grinding of the crude product with isohexane afforded 23 g (83% yield) of 2,4-difluoro-3-bromoaniline as a light yellow solid. The product was characterized by 1H NMR (360 MHz, CDCl3): δ 3.51 (2H, br), 6.65-6.70 (1H, m), 6.75-6.80 (1H, m).

References

[1] Patent: WO2003/93272, 2003, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5927 - 5932
[3] Patent: CN108117553, 2018, A. Location in patent: Paragraph 0105; 0106; 0122-0124
[4] Tetrahedron Letters, 2010, vol. 51, # 4, p. 600 - 601
[5] Patent: WO2015/54572, 2015, A1. Location in patent: Page/Page column 279

3-Bromo-2,4-difluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-2,4-difluoroaniline manufacturers

Career Henan Chemical Co

Product: 3-Bromo-2,4-difluoroaniline 103977-79-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 200KG
Release date: 2020-01-07

103977-79-3, 3-Bromo-2,4-difluoroanilineRelated Search:

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3-Bromo-2,4-difluoroaniline

3-Bromo-2,4-difluorophenylamine

2-bromo-1,3-difluoro-4-aminobenzene

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BenzenaMine, 3-broMo-2,4-difluoro-

Hexanoicacid,5-methyl-6-oxo-,ethylester

103977-79-3