3-Bromo-2-fluorobenzonitrile

Uses

Product Name: 3-Bromo-2-fluorobenzonitrile
CAS No.: 840481-82-5
Chemical Name: 3-Bromo-2-fluorobenzonitrile
Synonyms: 3-Bromo-2-fluorobenzonitrile;Benzonitrile, 3-broMo-2-fluoro-;1-Bromo-3-cyano-2-fluorobenzene;3-BROMO-2-FLUOROBENZONITRILE 96%;Benzonitrile, 3-bromo-2-fluoro- (9CI);KaiXinTianRui Technology Development Co., Ltd
CBNumber: CB01047006
Molecular Formula: C7H3BrFN
Formula Weight: 200.01
MOL File: 840481-82-5.mol

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3-Bromo-2-fluorobenzonitrile Property

Melting point:: 37-40°C
Boiling point:: 221.9±20.0 °C(Predicted)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: crystalline powder
color: Very faint orange
InChI: InChI=1S/C7H3BrFN/c8-6-3-1-2-5(4-10)7(6)9/h1-3H
InChIKey: AMKVZJOQZLIOSL-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=CC(Br)=C1F
CAS DataBase Reference: 840481-82-5

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Safety

Hazard Codes: Xi
RIDADR: 3439
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B692025
Product name: 3-Bromo-2-fluorobenzonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: X2754
Product name: 3-Bromo-2-fluorobenzonitrile
Packaging: 250mg
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB11492
Product name: 3-Bromo-2-fluorobenzonitrile
Packaging: 5G
Price: $86
Updated: 2021/12/16

Matrix Scientific

Product number: 024302
Product name: 3-Bromo-2-fluorobenzonitrile
Purity: 97%
Packaging: 500mg
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 024302
Product name: 3-Bromo-2-fluorobenzonitrile
Purity: 97%
Packaging: 1g
Price: $15
Updated: 2021/12/16

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3-Bromo-2-fluorobenzonitrile Chemical Properties,Usage,Production

Uses

3-Bromo-2-fluorobenzonitrile is an organic intermediate that can be prepared from 3-bromo-2-fluorobenzoic acid in two steps. 3-Bromo-2-fluorobenzonitrile can be used as a pharmaceutical intermediate in the preparation of STK4 inhibitors.

Synthesis

To a N, N-dimethylformamide solution (10 mL) of 3-bromo-2- fluorobenzamide (867 mg) was added to cyanuric chloride (806 mg) under ice-cooling, and the mixture was stirred overnight at room temperature. The mixture was diluted with ethyl acetate, and the organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. Purification by silica gel column chromatography (hexane: ethyl acetate = 1:0 - 1:1) gave 3-Bromo-2-fluorobenzonitrile (760 mg, yield 96%) as colorless crystals.

References

[1] Patent: WO2008/156757, 2008, A1. Location in patent: Page/Page column 139
[2] Patent: WO2016/161145, 2016, A1. Location in patent: Paragraph 00753

3-Bromo-2-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-2-fluorobenzonitrile Suppliers

China 151 Europe 1 India 2 United Kingdom 5 United States 12 Global 171

Jalor-Chem co.,LTD

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View Lastest Price from 3-Bromo-2-fluorobenzonitrile manufacturers

Hebei Fengjia New Material Co., Ltd

Product: Benzonitrile, 3-bromo-2-fluoro- (9CI) 840481-82-5
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: Benzonitrile, 3-bromo-2-fluoro- (9CI) 840481-82-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-02

Career Henan Chemical Co

Product: Benzonitrile, 3-bromo-2-fluoro- (9CI) 840481-82-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

840481-82-5, 3-Bromo-2-fluorobenzonitrileRelated Search:

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3-BROMO-2-FLUOROBENZONITRILE 96%

Benzonitrile, 3-bromo-2-fluoro- (9CI)

KaiXinTianRui Technology Development Co., Ltd

1-Bromo-3-cyano-2-fluorobenzene

Benzonitrile, 3-broMo-2-fluoro-

3-Bromo-2-fluorobenzonitrile

840481-82-5

84081-82-5

Fluorine series

FLUORO

Bromine Compounds

Fluorine Compounds

Nitriles