3-Bromo-4-fluoroaniline

Product Name: 3-Bromo-4-fluoroaniline
CAS No.: 656-64-4
Chemical Name: 3-Bromo-4-fluoroaniline
Synonyms: 3-Bromo-4-fluorobenzenamine;CL032;3-Bromo-4-fL;3-Bromo-4-flu;3-Bromo-4-fluoroanil;3-Bromo-4-fluoroanline;4-Fluoro-3-bromoaniline;3-BROMO-4-FLUOROANILINE;3-Bromo-4-fluoroaniline98%;3-Bromo-4-fluoroaniline 98%
CBNumber: CB1186895
Molecular Formula: C6H5BrFN
Formula Weight: 190.01
MOL File: 656-64-4.mol

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3-Bromo-4-fluoroaniline Property

Melting point:: 34-36°C
Boiling point:: 235°C
Density: 1.694±0.06 g/cm3(Predicted)
Flash point:: 235°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to lump
pka: 3.58±0.10(Predicted)
color: White to Orange to Green
Water Solubility: Insoluble in water.
Sensitive: Air Sensitive
InChI: InChI=1S/C6H5BrFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2
InChIKey: KOWPUNQBGWIERF-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(F)C(Br)=C1
CAS DataBase Reference: 656-64-4(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 36/37/38-36-36/38-20/21/22
Safety Statements: 26-36/37/39-36/37
RIDADR: UN2811
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B2957
Product name: 3-Bromo-4-fluoroaniline
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $54
Updated: 2025/07/31

TRC

Product number: B803468
Product name: 3-Bromo-4-fluoroaniline
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: B803468
Product name: 3-Bromo-4-fluoroaniline
Packaging: 10g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 013091
Product name: 3-Bromo-4-fluoroaniline
Packaging: 5g
Price: $10
Updated: 2021/12/16

Apolloscientific

Product number: PC9908
Product name: 3-Bromo-4-fluoroaniline
Purity: 98%
Packaging: 5g
Price: $10
Updated: 2021/12/16

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3-Bromo-4-fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

light yellow crystal

Uses

3-Bromo-4-fluoroaniline is used in organic synthesis as an intermediate of agrochemicals and active pharmaceutical ingredient.

Synthesis

701-45-1

656-64-4

In a 2L four-necked round-bottomed flask equipped with a stirrer, an Erlenmeyer condenser, a 1L dropping funnel, and a thermometer, 466.9 g (2.07 mol) of tin chloride dihydrate and 760 mL of ethanol were added and the mixture was stirred to room temperature. After the tin chloride was completely dissolved, 102.7 g (0.466 mol) of THF solution of 3-bromo-4-fluoronitrobenzene (760 mL) was slowly added dropwise, followed by continuous stirring for 2 hours at 60 °C. Upon completion of the reaction, the reaction solution was cooled to room temperature and the solvent was removed by distillation under reduced pressure. To the residue, 440 g of ice was added and adjusted to alkaline with 1580 mL of aqueous 7% sodium hydroxide. The slurry formed was separated by filtration and the solid residue was washed with 600 mL of dichloromethane (DCM). The filtrates were combined, the organic layer was separated and the aqueous layer was extracted with 600mL DCM. All DCM layers were combined, washed with 600mL of water and subsequently dried with potassium carbonate. After drying, potassium carbonate was removed by filtration and solvent was removed by distillation under reduced pressure. Finally, the crude product was purified by silica gel column chromatography using toluene as the unfolding agent to give 54.7 g (61.7% yield) of 3-bromo-4-fluoroaniline.

References

[1] Journal of Organic Chemistry, 1981, vol. 46, # 11, p. 2280 - 2286
[2] Patent: JP2018/90561, 2018, A. Location in patent: Paragraph 0088
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 369-370
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 6, p. 2538 - 2548

3-Bromo-4-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-4-fluoroaniline Suppliers

Americas 1 China 287 Europe 2 Germany 2 India 8 Italy 1 Japan 1 Russia 1 Ukraine 1 United Kingdom 11 United States 25 Global 340

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
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Nanjing Wanpu Pharmaceutical Technology Co.,Ltd

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Energy Chemical

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View Lastest Price from 3-Bromo-4-fluoroaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Bromo-4-fluoroaniline 656-64-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Bromo-4-fluoroaniline 656-64-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Hebei Miaobian Biotechnology Co., Ltd

Product: 3-Bromo-4-fluoroaniline 656-64-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99
Supply Ability: 10Ton
Release date: 2021-03-10

656-64-4, 3-Bromo-4-fluoroanilineRelated Search:

2-Bromoaniline 2-Fluoroaniline 4-Bromoaniline Ethyl bromodifluoroacetate 2,4,5-Trifluoroaniline 3-Bromoaniline 4-(Trifluoromethoxy)aniline 4-Fluoroaniline 3-BROMO-4-FLUOROPYRIDINE 1-Amino-3-bromo-4-fluorobenzene hydrochloride 5-BROMO-2,4-DIFLUOROANILINE 3-BROMO-4,5-DIFLUOROANILINE 4-Bromo-5-fluoro-2-nitrotoluene 3-Bromo-4-fluoronitrobenzene 3-Fluoro-4-broMoaniline 2-BROMO-3-FLUOROANILINE 2,4-DIBROMO-6-FLUOROANILINE Bromine

3-Bromo-4-flu

3 - broMine - 4 - fluoro aniline

3-Bromo-4-fluorophenylamine

3-BROMO-4-FLUOROANILINE

3-Bromo-4-fluoroaniline 98%

3-Bromo-4-fluoroaniline98%

3-Bromo-4-fluoroanline

3-Bromo-4-fluorobenzenamine

BENZENAMINE, 3-BROMO-4-FLUORO-

CL032

4-Fluoro-3-bromoaniline

3-Bromo-4-fluoroanil

3-Bromo-4-fL

3-Bromo-4-fluoroaniline &gt

3-Bromo-4-fluoroaniline ISO 9001：2015 REACH

3-Bromo-4-fluoroaniline, 97%

656-64-4

656-64-6

626-64-4

Miscellaneous

Anilines, Amides & Amines

Bromine Compounds

Fluorine Compounds

Aniline series

Fluorine series

Oxetanes

bc0001