3-Bromo-4-fluoroaniline
- Product Name
- 3-Bromo-4-fluoroaniline
- CAS No.
- 656-64-4
- Chemical Name
- 3-Bromo-4-fluoroaniline
- Synonyms
- 3-Bromo-4-fluorobenzenamine;CL032;3-Bromo-4-fL;3-Bromo-4-flu;3-Bromo-4-fluoroanil;3-Bromo-4-fluoroanline;4-Fluoro-3-bromoaniline;3-BROMO-4-FLUOROANILINE;3-Bromo-4-fluoroaniline98%;3-Bromo-4-fluoroaniline 98%
- CBNumber
- CB1186895
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 656-64-4.mol
3-Bromo-4-fluoroaniline Property
- Melting point:
- 34-36°C
- Boiling point:
- 235°C
- Density
- 1.694±0.06 g/cm3(Predicted)
- Flash point:
- 235°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to lump
- pka
- 3.58±0.10(Predicted)
- color
- White to Orange to Green
- Water Solubility
- Insoluble in water.
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C6H5BrFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2
- InChIKey
- KOWPUNQBGWIERF-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(F)C(Br)=C1
- CAS DataBase Reference
- 656-64-4(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 36/37/38-36-36/38-20/21/22
- Safety Statements
- 26-36/37/39-36/37
- RIDADR
- UN2811
- Hazard Note
- Toxic
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B2957
- Product name
- 3-Bromo-4-fluoroaniline
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- B803468
- Product name
- 3-Bromo-4-fluoroaniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B803468
- Product name
- 3-Bromo-4-fluoroaniline
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 012817
- Product name
- 3-Bromo-4-fluoroaniline
- Purity
- 98%
- Packaging
- 100g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 013091
- Product name
- 3-Bromo-4-fluoroaniline
- Packaging
- 100g
- Price
- $55
- Updated
- 2021/12/16
3-Bromo-4-fluoroaniline Chemical Properties,Usage,Production
Chemical Properties
light yellow crystal
Uses
3-Bromo-4-fluoroaniline is used in organic synthesis as an intermediate of agrochemicals and active pharmaceutical ingredient.
Synthesis
701-45-1
656-64-4
In a 2L four-necked round-bottomed flask equipped with a stirrer, an Erlenmeyer condenser, a 1L dropping funnel, and a thermometer, 466.9 g (2.07 mol) of tin chloride dihydrate and 760 mL of ethanol were added and the mixture was stirred to room temperature. After the tin chloride was completely dissolved, 102.7 g (0.466 mol) of THF solution of 3-bromo-4-fluoronitrobenzene (760 mL) was slowly added dropwise, followed by continuous stirring for 2 hours at 60 °C. Upon completion of the reaction, the reaction solution was cooled to room temperature and the solvent was removed by distillation under reduced pressure. To the residue, 440 g of ice was added and adjusted to alkaline with 1580 mL of aqueous 7% sodium hydroxide. The slurry formed was separated by filtration and the solid residue was washed with 600 mL of dichloromethane (DCM). The filtrates were combined, the organic layer was separated and the aqueous layer was extracted with 600mL DCM. All DCM layers were combined, washed with 600mL of water and subsequently dried with potassium carbonate. After drying, potassium carbonate was removed by filtration and solvent was removed by distillation under reduced pressure. Finally, the crude product was purified by silica gel column chromatography using toluene as the unfolding agent to give 54.7 g (61.7% yield) of 3-bromo-4-fluoroaniline.
References
[1] Journal of Organic Chemistry, 1981, vol. 46, # 11, p. 2280 - 2286
[2] Patent: JP2018/90561, 2018, A. Location in patent: Paragraph 0088
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 369-370
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 6, p. 2538 - 2548
3-Bromo-4-fluoroaniline Preparation Products And Raw materials
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View Lastest Price from 3-Bromo-4-fluoroaniline manufacturers
- Product
- 3-Bromo-4-fluoroaniline 656-64-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-09
- Product
- 3-Bromo-4-fluoroaniline 656-64-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-Bromo-4-fluoroaniline 656-64-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.99
- Supply Ability
- 10Ton
- Release date
- 2021-03-10