2-Bromo-3-fluoroaniline
- Product Name
- 2-Bromo-3-fluoroaniline
- CAS No.
- 111721-75-6
- Chemical Name
- 2-Bromo-3-fluoroaniline
- Synonyms
- 2-BROMO-3-FLUORO-PHENYLAMINE;Bromo-3-fluoroaniline;2-BROMO-3-FLUOROANILINE;2-Bromo-3-fluoroaniline 98%;Benzenamine, 2-bromo-3-fluoro-;2-Bromo-3-fluoroaniline, 97%, for synthesis;2-Bromo-3-fluoroaniline ISO 9001：2015 REACH;2-Bromo-3-fluorophenylamine,2-Bromo-3-fluoroaniline
- CBNumber
- CB4777632
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 111721-75-6.mol
2-Bromo-3-fluoroaniline Property
- Melting point:
- 32-34 °C
- Boiling point:
- 229.8±20.0 °C(Predicted)
- Density
- 1.670
- Flash point:
- 94°(201°F)
- refractive index
- 1.5830
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Crystalline
- pka
- 1.52±0.10(Predicted)
- color
- Off-white
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H5BrFN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2
- InChIKey
- XZRSXRUYZXBTGD-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(F)=C1Br
- CAS DataBase Reference
- 111721-75-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36-36/37/38-20/21/22
- Safety Statements
- 9-26-36/37-60
- RIDADR
- 2811
- Hazard Note
- Harmful/Irritant
- HazardClass
- 6.1
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B961495
- Product name
- 2-Bromo-3-fluoroaniline
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B961495
- Product name
- 2-Bromo-3-fluoroaniline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB67928
- Product name
- 2-Bromo-3-fluoroaniline
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- X8981
- Product name
- 2-Bromo-3-fluoroaniline
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
- Product number
- PC5082
- Product name
- 2-Bromo-3-fluoroaniline
- Purity
- 98%
- Packaging
- 5g
- Price
- $91
- Updated
- 2021/12/16
2-Bromo-3-fluoroaniline Chemical Properties,Usage,Production
Chemical Properties
Light yellow liquid
Uses
2-Bromo-3-fluoroaniline is used as pharmaceutical intermediate.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 27, p. 2151, 1990 DOI: 10.1002/jhet.5570270755
Synthesis
59255-94-6
111721-75-6
General procedure for the synthesis of 2-bromo-3-fluoroaniline from 2-bromo-3-fluoro nitrobenzene: 2-bromo-1-fluoro-3-nitrobenzene (1.0 g, 5.0 mmol) was dissolved in methanol (50 mL) at 0 °C, and NiCl? (2.2 g, 10 mmol) and NaBH? (0.50 g, 14 mmol) were added sequentially. After the addition was completed, the reaction mixture was stirred at 0 °C for 5 min. Subsequently, the reaction was quenched by the addition of water (20 mL) and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried over anhydrous Na?SO? and concentrated under reduced pressure to afford 2-bromo-3-fluoroaniline (600 mg, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl?): δ 7.07-7.02 (m, 1H), 6.55-6.49 (m, 1H), 4.22 (br s, 2H).
References
[1] Patent: CN108002976, 2018, A. Location in patent: Paragraph 0045; 0047; 0050; 0051; 0060; 0069
[2] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437
[3] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 121
[4] Patent: US2011/98311, 2011, A1
[5] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1674
2-Bromo-3-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-3-fluoroaniline manufacturers
- Product
- 2-Bromo-3-fluoroaniline 111721-75-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-08