ChemicalBook > CAS DataBase List > 2-Bromo-3-fluoroaniline

2-Bromo-3-fluoroaniline

Product Name
2-Bromo-3-fluoroaniline
CAS No.
111721-75-6
Chemical Name
2-Bromo-3-fluoroaniline
Synonyms
2-BROMO-3-FLUORO-PHENYLAMINE;Bromo-3-fluoroaniline;2-BROMO-3-FLUOROANILINE;2-Bromo-3-fluoroaniline 98%;Benzenamine, 2-bromo-3-fluoro-;2-Bromo-3-fluoroaniline, 97%, for synthesis;2-Bromo-3-fluoroaniline ISO 9001：2015 REACH;2-Bromo-3-fluorophenylamine,2-Bromo-3-fluoroaniline
CBNumber
CB4777632
Molecular Formula
C6H5BrFN
Formula Weight
190.01
MOL File
111721-75-6.mol
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2-Bromo-3-fluoroaniline Property

Melting point:
32-34 °C
Boiling point:
229.8±20.0 °C(Predicted)
Density 
1.670
Flash point:
94°(201°F)
refractive index 
1.5830
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Crystalline
pka
1.52±0.10(Predicted)
color 
Off-white
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C6H5BrFN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2
InChIKey
XZRSXRUYZXBTGD-UHFFFAOYSA-N
SMILES
C1(N)=CC=CC(F)=C1Br
CAS DataBase Reference
111721-75-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36-36/37/38-20/21/22
Safety Statements 
9-26-36/37-60
RIDADR 
2811
Hazard Note 
Harmful/Irritant
HazardClass 
6.1
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B961495
Product name
2-Bromo-3-fluoroaniline
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
B961495
Product name
2-Bromo-3-fluoroaniline
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB67928
Product name
2-Bromo-3-fluoroaniline
Packaging
10g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
X8981
Product name
2-Bromo-3-fluoroaniline
Packaging
1g
Price
$83
Updated
2021/12/16
Apolloscientific
Product number
PC5082
Product name
2-Bromo-3-fluoroaniline
Purity
98%
Packaging
5g
Price
$91
Updated
2021/12/16
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2-Bromo-3-fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

2-Bromo-3-fluoroaniline is used as pharmaceutical intermediate.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 2151, 1990 DOI: 10.1002/jhet.5570270755

Synthesis

59255-94-6

111721-75-6

General procedure for the synthesis of 2-bromo-3-fluoroaniline from 2-bromo-3-fluoro nitrobenzene: 2-bromo-1-fluoro-3-nitrobenzene (1.0 g, 5.0 mmol) was dissolved in methanol (50 mL) at 0 °C, and NiCl? (2.2 g, 10 mmol) and NaBH? (0.50 g, 14 mmol) were added sequentially. After the addition was completed, the reaction mixture was stirred at 0 °C for 5 min. Subsequently, the reaction was quenched by the addition of water (20 mL) and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried over anhydrous Na?SO? and concentrated under reduced pressure to afford 2-bromo-3-fluoroaniline (600 mg, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl?): δ 7.07-7.02 (m, 1H), 6.55-6.49 (m, 1H), 4.22 (br s, 2H).

References

[1] Patent: CN108002976, 2018, A. Location in patent: Paragraph 0045; 0047; 0050; 0051; 0060; 0069
[2] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437
[3] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 121
[4] Patent: US2011/98311, 2011, A1
[5] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1674

2-Bromo-3-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-3-fluoroaniline manufacturers

Career Henan Chemical Co
Product
2-Bromo-3-fluoroaniline 111721-75-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-08

111721-75-6, 2-Bromo-3-fluoroanilineRelated Search:

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  • 2-BROMO-3-FLUOROANILINE
  • 2-BROMO-3-FLUORO-PHENYLAMINE
  • 2-Bromo-3-fluoroaniline 98%
  • Bromo-3-fluoroaniline
  • 2-Bromo-3-fluoroaniline, 97%, for synthesis
  • Benzenamine, 2-bromo-3-fluoro-
  • 2-Bromo-3-fluoroaniline ISO 9001：2015 REACH
  • 2-Bromo-3-fluorophenylamine,2-Bromo-3-fluoroaniline
  • 111721-75-6
  • 11721-75-6
  • Fluorine series
  • Pyridines
  • Aniline
  • Anilines, Aromatic Amines and Nitro Compounds