3-Fluoro-4-broMoaniline
- Product Name
- 3-Fluoro-4-broMoaniline
- CAS No.
- 656-65-5
- Chemical Name
- 3-Fluoro-4-broMoaniline
- Synonyms
- 4-Bromo-3-fluoroanil;3-Fluoro-4-broMoanilin;4-BROMO-3-FLUOROANILINE;4-Bromo-3-fluoroaniline98%;4-Bromo-3-fluorobenzenamine;4-BROMO-3-FLUOROPHENYLAMINE;4-Bromo-3-fluoroaniline >4-BroMo-3-fluoroaniline, 97+%;Benzenamine, 4-bromo-3-fluoro-;4 - broMine - 3 - fluoro aniline
- CBNumber
- CB9345779
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 656-65-5.mol
3-Fluoro-4-broMoaniline Property
- Melting point:
- 72-73°C
- Boiling point:
- 65-68 °C (lit.)
- Density
- 0.982 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.471(lit.)
- Flash point:
- 105 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Acetonitrile, Methanol
- form
- Crystalline Powder
- pka
- 2.88±0.10(Predicted)
- color
- Yellow to tan
- Water Solubility
- Soluble in acetonitrile, methanol. Insoluble in water.
- BRN
- 3236457
- InChI
- InChI=1S/C6H5BrFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
- InChIKey
- YTMVYYAKOPIJCZ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Br)C(F)=C1
- CAS DataBase Reference
- 656-65-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 518719
- Product name
- 4-Bromo-3-fluoroaniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $31.2
- Updated
- 2025/07/31
- Product number
- B2102
- Product name
- 4-Bromo-3-fluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- B2102
- Product name
- 4-Bromo-3-fluoroaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $65
- Updated
- 2025/07/31
- Product number
- B684550
- Product name
- 4-Bromo-3-fluoroaniline
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- HCH0023078
- Product name
- 4-BROMO-3-FLUOROANILINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $780.78
- Updated
- 2021/12/16
3-Fluoro-4-broMoaniline Chemical Properties,Usage,Production
Chemical Properties
Beige to brown needles and crystalline powder
Uses
4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.
Uses
4-Bromo-3-fluoroaniline is a intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4 ,4"-alkoxyalkylterphenyls.
Synthesis
351-30-4
656-65-5
General procedure for the synthesis of 4-bromo-3-fluoroaniline from 3-fluoro-4-bromoacetanilide: N-(4-bromo-3-fluorophenyl)acetamide (12.9 g, 12.9 mmol) was dissolved in ethanol (30 mL), and stirred until completely dissolved. Subsequently, concentrated hydrochloric acid (15 mL) was added to the solution and the reaction was refluxed at 80 °C for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with ice water and extracted with ethyl acetate. The organic layers were combined and washed sequentially with water and brine solution. Finally, the solvent was removed by vacuum distillation to afford 4-bromo-3-fluoroaniline (2.45 g, 100.0% yield) as an off-white solid.
References
[1] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 97; 98
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 43 - 64
[3] Journal of the Chemical Society, 1958, p. 2815,2818
3-Fluoro-4-broMoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-4-broMoaniline manufacturers
- Product
- 4-Bromo-3-fluoroaniline 656-65-5
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22
- Product
- 4-Bromo-3-fluoroaniline 656-65-5
- Price
- US $0.00/KG Ton
- Min. Order
- 1KG Ton
- Purity
- 98%+
- Supply Ability
- 2 tons/month
- Release date
- 2022-10-10
- Product
- 4-Bromo-3-fluoroaniline 656-65-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-13