2,5-Difluoronitrobenzene
- Product Name
- 2,5-Difluoronitrobenzene
- CAS No.
- 364-74-9
- Chemical Name
- 2,5-Difluoronitrobenzene
- Synonyms
- 1,4-DIFLUORO-2-NITROBENZENE;AKOS BBS-00006468;2,5-Difluoronitroben;3,5-diflurobenzalcohol;2,5-Difluotonitrobenzene;2,5-DIFLUORONITROBENZENE;1,4-difluoro-2-nitro-benzen;2,5-Difluoro-1-nitrobenzene;2,5-Difluoronitrobenzene98%;1-Nitro-2,5-difluorobenzene
- CBNumber
- CB0219938
- Molecular Formula
- C6H3F2NO2
- Formula Weight
- 159.09
- MOL File
- 364-74-9.mol
2,5-Difluoronitrobenzene Property
- Melting point:
- -11.7 °C (lit.)
- Boiling point:
- 206.5 °C (lit.)
- Density
- 1.467 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.509(lit.)
- Flash point:
- 194 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- color
- Clear yellow
- Specific Gravity
- 1.467
- Water Solubility
- insoluble
- BRN
- 2210200
- InChI
- InChI=1S/C6H3F2NO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
- InChIKey
- XNJAYQHWXYJBBD-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(F)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 364-74-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,5-Difluoronitrobenzene(364-74-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 196622
- Product name
- 2,5-Difluoronitrobenzene
- Purity
- 97%
- Packaging
- 25g
- Price
- $42.6
- Updated
- 2025/07/31
- Product number
- D1700
- Product name
- 2,5-Difluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $141
- Updated
- 2025/07/31
- Product number
- D447738
- Product name
- 2,5-Difluoronitrobenzene
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC2860
- Product name
- 2,5-Difluoronitrobenzene
- Purity
- 98%
- Packaging
- 50g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 4654-3-08
- Product name
- 2,5-Difluoronitrobenzene
- Purity
- 98%
- Packaging
- 25g
- Price
- $25
- Updated
- 2021/12/16
2,5-Difluoronitrobenzene Chemical Properties,Usage,Production
Chemical Properties
CLEAR YELLOW LIQUID
Uses
2,5-Difluoronitrobenzene was used in the synthesis of :
- N-alkylated 2-arylaminobenzimidazoles
- quinoxalinones
- N-(2-nitro-4-fluorophenyl)-l,2,3,4-tetrahydroisoquinoline
Synthesis
98-95-3
402-67-5
369-34-6
364-74-9
350-46-9
1493-27-2
GENERAL STEPS: In a FEP or PFA reactor fitted with a PTFE-lined magnetic stir bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 mL per mL of C6H5R), and BF3-Et2O (1.3-1.5 mmol/mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by batchwise addition of XeF2 (1.2-1.3 mmol/mmol C6H5R). After each addition, the mixture was stirred at 22-25 °C for 3-5 min and recooled. After the addition was completed, the dark solution was continued to be stirred at 22-25 °C for 15-30 min. At the end of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the upper organic layer was separated and filtered through a short column packed with silica gel (40-60 μm) and subsequently dried with magnesium sulfate. The final products were analyzed by 19F NMR and GC/MS. The major products are listed in the table and the others are as follows (with GC/MS data).
References
[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8
2,5-Difluoronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Difluoronitrobenzene manufacturers
- Product
- 2,5-Difluoronitrobenzene 364-74-9
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-08
- Product
- 2,5-Difluoronitrobenzene 364-74-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-06-11
- Product
- 2,5-Difluoronitrobenzene 364-74-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18