1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
- Product Name
- 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
- CAS No.
- 141412-60-4
- Chemical Name
- 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
- Synonyms
- 2-Difluoro-4-nitrotoluene;2，5-Difluoro-4-nitrotoluene;2,5-Difluoro-4-methyinitrobenzene;2,5-Difluoro-4-methylnitrobenzene;4-DIFLUORO-2-METHYL-5-NITROBENZENE;1,4-DIFLUORO-2-METHYL-5-NITROBENZENE;Benzene, 1,4-difluoro-2-methyl-5-nitro-;1,4-DIFLUORO-2-METHYL-5-NITROBENZENE ISO 9001：2015 REACH;1,4-Difluoro-2-Methyl-5-nitrobenzene[2,5-difluoro-4-nitrotoluene];2,5-Difluoro-4-methylnitrobenzene, 1,4-Difluoro-2-methyl-5-nitrobe
- CBNumber
- CB5420294
- Molecular Formula
- C7H5F2NO2
- Formula Weight
- 173.12
- MOL File
- 141412-60-4.mol
1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Property
- Melting point:
- 25 °C
- Boiling point:
- 251 ºC
- Density
- 1.374
- Flash point:
- 121 ºC
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to lump to clear liquid
- color
- White or Colorless to Yellow to Green
- CAS DataBase Reference
- 141412-60-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4806
- Product name
- 2,5-Difluoro-4-nitrotoluene
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- D4806
- Product name
- 2,5-Difluoro-4-nitrotoluene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $205
- Updated
- 2025/07/31
- Product number
- D448598
- Product name
- 1,4-Difluoro-2-methyl-5-nitrobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D448598
- Product name
- 1,4-Difluoro-2-methyl-5-nitrobenzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D448598
- Product name
- 1,4-Difluoro-2-methyl-5-nitrobenzene
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 2321, 1992 DOI: 10.1021/jm00090a024
Synthesis
452-67-5
141412-60-4
General procedure for the synthesis of 2,5-difluoro-4-nitrotoluene from 2,5-difluorotoluene: To a stirred solution of 2,5-difluorotoluene (0.544 g, 4.25 mmol, Aldrich, for direct use) in concentrated sulfuric acid (5.0 mL) was added a single addition of potassium nitrate (KNO3, 0.430 g, 4.25 mmol) at 0 °C. The reaction mixture was gradually warmed to 28 °C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was quenched by pouring into ice (25 g) and extracted with ethyl acetate (40 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 2,5-difluoro-4-nitrotoluene (0.555 g, 91% yield) as a light red oil. The product was characterized by 1H NMR (CDCl3): δ 2.369 (d, 3H, J = 1.8 Hz), 7.127 (dd, 1H, J1 = 8.1 Hz, J2 = 6.0 Hz), 7.734 (dd, 1H, J1 = 8.4 Hz, J2 = 6.3 Hz).
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2321 - 2327
[2] Journal of Organic Chemistry, 1995, vol. 60, # 18, p. 5838 - 5842
[3] Patent: US5631373, 1997, A
[4] Patent: WO2008/119720, 2008, A1. Location in patent: Page/Page column 54
1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE manufacturers
- Product
- 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE 141412-60-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 1,4-Difluoro-2-methyl-5-nitrobenzene 141412-60-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 1,4-Difluoro-2-methyl-5-nitrobenzene 141412-60-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10