ChemicalBook > CAS DataBase List > 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE

1,4-DIFLUORO-2-METHYL-5-NITROBENZENE

Product Name
1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
CAS No.
141412-60-4
Chemical Name
1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
Synonyms
2-Difluoro-4-nitrotoluene;2，5-Difluoro-4-nitrotoluene;2,5-Difluoro-4-methyinitrobenzene;2,5-Difluoro-4-methylnitrobenzene;4-DIFLUORO-2-METHYL-5-NITROBENZENE;1,4-DIFLUORO-2-METHYL-5-NITROBENZENE;Benzene, 1,4-difluoro-2-methyl-5-nitro-;1,4-DIFLUORO-2-METHYL-5-NITROBENZENE ISO 9001：2015 REACH;1,4-Difluoro-2-Methyl-5-nitrobenzene[2,5-difluoro-4-nitrotoluene];2,5-Difluoro-4-methylnitrobenzene, 1,4-Difluoro-2-methyl-5-nitrobe
CBNumber
CB5420294
Molecular Formula
C7H5F2NO2
Formula Weight
173.12
MOL File
141412-60-4.mol
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1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Property

Melting point:
25 °C
Boiling point:
251 ºC
Density 
1.374
Flash point:
121 ºC
storage temp. 
Sealed in dry,Room Temperature
form 
powder to lump to clear liquid
color 
White or Colorless to Yellow to Green
CAS DataBase Reference
141412-60-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4806
Product name
2,5-Difluoro-4-nitrotoluene
Purity
>98.0%(GC)
Packaging
1g
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
D4806
Product name
2,5-Difluoro-4-nitrotoluene
Purity
>98.0%(GC)
Packaging
5g
Price
$205
Updated
2025/07/31
TRC
Product number
D448598
Product name
1,4-Difluoro-2-methyl-5-nitrobenzene
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
D448598
Product name
1,4-Difluoro-2-methyl-5-nitrobenzene
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
D448598
Product name
1,4-Difluoro-2-methyl-5-nitrobenzene
Packaging
1g
Price
$75
Updated
2021/12/16
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1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 2321, 1992 DOI: 10.1021/jm00090a024

Synthesis

452-67-5

141412-60-4

General procedure for the synthesis of 2,5-difluoro-4-nitrotoluene from 2,5-difluorotoluene: To a stirred solution of 2,5-difluorotoluene (0.544 g, 4.25 mmol, Aldrich, for direct use) in concentrated sulfuric acid (5.0 mL) was added a single addition of potassium nitrate (KNO3, 0.430 g, 4.25 mmol) at 0 °C. The reaction mixture was gradually warmed to 28 °C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was quenched by pouring into ice (25 g) and extracted with ethyl acetate (40 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 2,5-difluoro-4-nitrotoluene (0.555 g, 91% yield) as a light red oil. The product was characterized by 1H NMR (CDCl3): δ 2.369 (d, 3H, J = 1.8 Hz), 7.127 (dd, 1H, J1 = 8.1 Hz, J2 = 6.0 Hz), 7.734 (dd, 1H, J1 = 8.4 Hz, J2 = 6.3 Hz).

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2321 - 2327
[2] Journal of Organic Chemistry, 1995, vol. 60, # 18, p. 5838 - 5842
[3] Patent: US5631373, 1997, A
[4] Patent: WO2008/119720, 2008, A1. Location in patent: Page/Page column 54

1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DIFLUORO-2-METHYL-5-NITROBENZENE Suppliers

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View Lastest Price from 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE manufacturers

Henan Fengda Chemical Co., Ltd
Product
1,4-DIFLUORO-2-METHYL-5-NITROBENZENE 141412-60-4
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-26
Honest Joy Holdings Limited
Product
1,4-Difluoro-2-methyl-5-nitrobenzene 141412-60-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.2%
Supply Ability
100 tons
Release date
2022-01-26
Shaanxi Dideu Medichem Co. Ltd
Product
1,4-Difluoro-2-methyl-5-nitrobenzene 141412-60-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2020-01-10

141412-60-4, 1,4-DIFLUORO-2-METHYL-5-NITROBENZENERelated Search:

2,4-difluoro-N-methyl-5-nitrobenzene-1-sulfonamide 1,3-difluoro-2-methyl-4-nitrobenzene 2,5-difluoro-1-methyl-3-nitrobenzene 2,4,5-TRIFLUORO-3-METHYL-6-NITROBENZOIC ACID 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE 2,5-Difluoro-4-nitrobenzoic acid 2,5-DIFLUORO-4-NITROBENZYL BROMIDE METHYL 2,5-DIFLUORO-4-NITROBENZENECARBOXYLATE

  • 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
  • 2,5-Difluoro-4-methylnitrobenzene
  • 2，5-Difluoro-4-nitrotoluene
  • 2,5-Difluoro-4-methyinitrobenzene
  • 2,5-Difluoro-4-methylnitrobenzene, 1,4-Difluoro-2-methyl-5-nitrobenzene
  • 1,4-Difluoro-2-Methyl-5-nitrobenzene[2,5-difluoro-4-nitrotoluene]
  • Benzene, 1,4-difluoro-2-methyl-5-nitro-
  • 2-Difluoro-4-nitrotoluene
  • 2,5-Difluoro-4-methylnitrobenzene, 1,4-Difluoro-2-methyl-5-nitrobe
  • 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE ISO 9001：2015 REACH
  • 4-DIFLUORO-2-METHYL-5-NITROBENZENE
  • 141412-60-4
  • Halogen toluene