2,6-Difluoronitrobenzene
Uses- Product Name
- 2,6-Difluoronitrobenzene
- CAS No.
- 19064-24-5
- Chemical Name
- 2,6-Difluoronitrobenzene
- Synonyms
- 1,3-DIFLUORO-2-NITROBENZENE;2,6-Difluoronitroben;6-Difluoronitrobenzene;2,6-Difluoronitrobenzne;2,6-DIFLUORONITROBENZENE;1,3-Difluor-2-nitrobenzol;2,6-Difluoro-1-nitrobenzene;2,6-Difluoronitrobenzene98%;2,6-Difluoronitrobenzene>2,6-Difluoronitrobenzene 98%
- CBNumber
- CB8439211
- Molecular Formula
- C6H3F2NO2
- Formula Weight
- 159.09
- MOL File
- 19064-24-5.mol
2,6-Difluoronitrobenzene Property
- Melting point:
- 0C
- Boiling point:
- 91-92 °C/11 mmHg (lit.)
- Density
- 1.503 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.494(lit.)
- Flash point:
- 190 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to lump to clear liquid
- color
- Light yellow to Yellow to Green
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H3F2NO2/c7-4-2-1-3-5(8)6(4)9(10)11/h1-3H
- InChIKey
- SSNCMIDZGFCTST-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=CC(F)=C1[N+]([O-])=O
- CAS DataBase Reference
- 19064-24-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 382957
- Product name
- 2,6-Difluoronitrobenzene
- Purity
- 98%
- Packaging
- 5g
- Price
- $128
- Updated
- 2025/07/31
- Product number
- 382957
- Product name
- 2,6-Difluoronitrobenzene
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- D4123
- Product name
- 2,6-Difluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- D4123
- Product name
- 2,6-Difluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $144
- Updated
- 2025/07/31
- Product number
- D447193
- Product name
- 1,3-Difluoro-2-nitrobenzene
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
2,6-Difluoronitrobenzene Chemical Properties,Usage,Production
Uses
1,3-Difluoro-2-nitrobenzene is a useful chemical reagent.
Chemical Properties
Light yellow to dark yellow solid
Uses
2,6-Difluoronitrobenzene may be used in the preparation of secondary amine precursors, required for the synthesis of two families of nitric oxide donors.
General Description
2,6-Difluoronitrobenzene is an organic building block. Molecular structure, conformation and potential to internal rotation of 2,6-difluoronitrobenzene been studied by gas-phase electron diffraction (GED), MP2 ab initio, and by B3LYP density functional calculations.
Synthesis
5509-65-9
19064-24-5
Step 1: A mixture of sodium perborate tetrahydrate (65 g, 422 mmol) in glacial acetic acid (250 mL) was stirred at 80 °C. 2,6-Difluoroaniline (11.0 g, 85 mmol) was dissolved in glacial acetic acid (50 mL) and slowly added to the above mixture. The reaction temperature was maintained between 80-90°C for 1 hour. The cooled reaction mixture was poured into water and extracted twice with ether. The organic layers were combined, washed with dilute sodium bicarbonate solution, dried over anhydrous magnesium sulfate and the solvent evaporated. The residue was purified by a Biotage fast chromatography system (FlasH90i, silica gel column, 10% THF/hexane as eluent) and the product was washed with hexane to give 2,6-difluoronitrobenzene (7.0 g, 52% yield). Mass spectrum (ESI) m/z 160 ([M + H]+).
References
[1] Patent: US2005/222148, 2005, A1. Location in patent: Page/Page column 58
[2] Patent: US2008/153873, 2008, A1. Location in patent: Page/Page column 20
[3] Journal of Organic Chemistry, 1992, vol. 57, # 21, p. 5577 - 5585
[4] European Journal of Organic Chemistry, 2006, # 5, p. 1109 - 1112
[5] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 8
2,6-Difluoronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Difluoronitrobenzene manufacturers
- Product
- 2,6-Difluoronitrobenzene 19064-24-5
- Price
- US $80.00-800.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-07
- Product
- 2,6-Difluoronitrobenzene 19064-24-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2,6-Difluoronitrobenzene 19064-24-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09