1-Bromo-2,5-difluorobenzene

Product Name: 1-Bromo-2,5-difluorobenzene
CAS No.: 399-94-0
Chemical Name: 1-Bromo-2,5-difluorobenzene
Synonyms: 2-BROMO-1,4-DIFLUOROBENZENE;NSC 10250;2-Bromo-1,4-difL;1-Bromo-2,5-difluoro;2,5-DIFLUOROBROMOBENZENE;2-Brom-1,4-difluorbenzol;1,4-Difluoro-2-bromobenzene;1-BROMO-2,5-DIFLUOROBENZENE;2,5-Difluorobromobenzene 98%;1-Bromo-2,5-difluorobenzene98%
CBNumber: CB2701983
Molecular Formula: C6H3BrF2
Formula Weight: 192.99
MOL File: 399-94-0.mol

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1-Bromo-2,5-difluorobenzene Property

Melting point:: −31 °C(lit.)
Boiling point:: 58-59 °C20 mm Hg(lit.)
Density: 1.708 g/mL at 25 °C(lit.)
refractive index: n20/D 1.508(lit.)
Flash point:: 149 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
Specific Gravity: 1.708
color: Colorless to Light yellow to Light orange
Water Solubility: Insoluble
BRN: 1680893
InChI: InChI=1S/C6H3BrF2/c7-5-3-4(8)1-2-6(5)9/h1-3H
InChIKey: XCRCSPKQEDMVBO-UHFFFAOYSA-N
SMILES: C1(F)=CC=C(F)C=C1Br
CAS DataBase Reference: 399-94-0(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 2-bromo-1,4-difluoro-(399-94-0)

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Safety

Hazard Codes: Xi,F,Xn
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-2637/39-37/39
RIDADR: UN 2922
WGK Germany: 3
Hazard Note: Flammable
HazardClass: IRRITANT, FLAMMABLE
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 247952
Product name: 2-Bromo-1,4-difluorobenzene
Purity: 98%
Packaging: 5g
Price: $45.1
Updated: 2023/06/20

TCI Chemical

Product number: B1166
Product name: 1-Bromo-2,5-difluorobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B1166
Product name: 1-Bromo-2,5-difluorobenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $68
Updated: 2025/07/31

TRC

Product number: B689648
Product name: 2-Bromo-1,4-difluorobenzene
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J51055
Product name: 2,5-Difluorobromobenzene
Packaging: 500g
Price: $180
Updated: 2021/12/16

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1-Bromo-2,5-difluorobenzene Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Bromo-1,4-difluorobenzene has been used in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone.

General Description

Lithiation of 2-bromo-1,4-difluorobenzene in the presence of lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane and butyllithium in THF-hexane has been reported.

Synthesis

108-86-1

1072-85-1

399-94-0

1073-06-9

348-61-8

460-00-4

GENERAL STEPS: In a FEP or PFA reactor equipped with a PTFE-lined magnetic stir bar and connected to a gas scrubber bottle, substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (2 mL per mL of C6H5R), and BF3-Et2O (1.3-1.5 mmol/mmol C6H5R) were added. The mixture was stirred at 0-5 °C (ice bath) for 10-15 min, followed by batchwise addition of XeF2 (1.2-1.3 mmol/mmol C6H5R). After each addition, the mixture was stirred at 22-25 °C for 3-5 min and cooled to 0-5 °C again. After the addition was completed, the dark-colored solution was continued to be stirred at 22-25 °C for 15-30 min. Upon completion of the reaction, the reaction was quenched by the addition of 10% aqueous KHCO3, the upper organic layer was separated and filtered through a short column packed with silica gel (40-60 μm) and finally dried with magnesium sulfate. The solution was analyzed by 19F NMR and GC/MS. The major products are listed in the table and the others are as follows (GC/MS data provided).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

1-Bromo-2,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Bromo-2,5-difluorobenzene Suppliers

Americas 1 Belgium 4 China 343 Europe 4 France 3 Germany 7 India 8 Italy 1 Japan 8 Jordan 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 23 United States 54 Global 464

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View Lastest Price from 1-Bromo-2,5-difluorobenzene manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Bromo-2,5-difluorobenzene 399-94-0
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-07

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Bromo-2,5-difluorobenzene 399-94-0
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Henan Fengda Chemical Co., Ltd

Product: 1-Bromo-2,5-difluorobenzene 399-94-0
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

399-94-0, 1-Bromo-2,5-difluorobenzeneRelated Search:

2-Bromofluorobenzene 4'-Bromopropiophenone 2-Bromobenzonitrile 4-Bromofluorobenzene 1,3-Difluorobenzene 1,2-Difluorobenzene 3-Bromoanisole 1,3-Dibromobenzene 4-BROMO-2,5-DIFLUOROBENZENE-1-SULFONYL CHLORIDE Bromopentafluorobenzene 1,4-Dibromo-2,5-difluorobenzene 1-Bromo-2,4,5-trifluorobenzene 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE Bromine 1-BROMO-2,3-DIFLUOROBENZENE 1-Bromo-3,5-difluorobenzene98%,1-Bromo-3,5-difluorobenzene,98% [3,5-Difluorobromobenzene],1-Bromo-3,5-difluorobenzene 98%,1-BROMO-3,5-DIFLUOROBENZENE 4-Bromo-1,2-difluorobenzene 1-BROMO-2,4-DIFLUOROBENZENE,Bromo-2,4-difluorobenzen

1,4-Difluoro-2-bromobenzene

2,5-DIFLUOROBROMOBENZENE

2-BROMO-1,4-DIFLUOROBENZENE

1-BROMO-2,5-DIFLUOROBENZENE

1-Bromo-2,5-difluorobenzene 98%

1-Bromo-2,5-difluorobenzene98%

1-BROMO-2,5-DIFLUOROBENZENE 99.5%

1-Bromo-2,5-difluoro

2,5-Difluorobromobenzene 98%

2-Bromo-1,4-difluorobenzene 98%

NSC 10250

2-Bromo-1,4-difL

1-Bromo-2,5-difluorobenzene &gt

2-Brom-1,4-difluorbenzol

Benzene, 2-bromo-1,4-difluoro-

1-Bromo-2,5-difluorobenzene ISO 9001：2015 REACH

2-Bromo-1,4-difluorobenzene, 98%min

399-94-0

Halogenated Hydrocarbons

ARYL HALIDE

Aryl

Building Blocks

Organic Building Blocks

C6

Aryl

Halogenated Hydrocarbons

alkyl bromide| alkyl Fluorine

Aromatic Hydrocarbons (substituted) & Derivatives

Fluorobenzene

Miscellaneous

Bromine Compounds

Fluorine Compounds

Fluorobenzene Series

bc0001

C6