1-Bromo-3,5-difluorobenzene
- Product Name
- 1-Bromo-3,5-difluorobenzene
- CAS No.
- 461-96-1
- Chemical Name
- 1-Bromo-3,5-difluorobenzene
- Synonyms
- 3,5-DIFLUOROBROMOBENZENE;DM1Impurity22;uorobromobenzene;5-difluorobenzene;1-Bromo-3,5-difluoro;1-Brom-3,5-difluorbenzol;3,5-difluoro-1-bromobenzene;1-BROMO-3,5-DIFLUOROBENZENE;1-Bromo-3,5-difulorobenzene;1,3-Difluoro-5-bromobenzene
- CBNumber
- CB3668317
- Molecular Formula
- C6H3BrF2
- Formula Weight
- 192.99
- MOL File
- 461-96-1.mol
1-Bromo-3,5-difluorobenzene Property
- Melting point:
- -27 °C
- Boiling point:
- 140 °C (lit.)
- Density
- 1.676 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.499(lit.)
- Flash point:
- 112 °F
- storage temp.
- Sealed in dry,2-8°C
- solubility
- 0.238g/l
- form
- Liquid
- color
- Clear colorless to light yellow
- Specific Gravity
- 1.686
- PH
- 6.6 (0.238g/l, H2O, 20℃)
- Water Solubility
- 0.238 g/L (20 ºC)
- BRN
- 1931520
- InChIKey
- JHLKSIOJYMGSMB-UHFFFAOYSA-N
- CAS DataBase Reference
- 461-96-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,N,F,Xi
- Risk Statements
- 10-22-38-43-48/22-50/53-36/37/38
- Safety Statements
- 24-36/37-60-61-36-26-16
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 2
- Hazard Note
- Flammable
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- 290165
- Product name
- 1-Bromo-3,5-difluorobenzene
- Purity
- 98%
- Packaging
- 10g
- Price
- $58.66
- Updated
- 2025/07/31
- Product number
- 290165
- Product name
- 1-Bromo-3,5-difluorobenzene
- Purity
- 98%
- Packaging
- 100g
- Price
- $198.59
- Updated
- 2025/07/31
- Product number
- B1764
- Product name
- 1-Bromo-3,5-difluorobenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $60
- Updated
- 2025/07/31
- Product number
- B1764
- Product name
- 1-Bromo-3,5-difluorobenzene
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $241
- Updated
- 2025/07/31
- Product number
- 158405
- Product name
- 1-Bromo-3,5-difluorobenzene
- Packaging
- 25g
- Price
- $403
- Updated
- 2021/12/16
1-Bromo-3,5-difluorobenzene Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Uses
1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid.
Uses
Intermediates of Liquid Crystals
Synthesis Reference(s)
Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008
Synthesis
6303-21-5
101471-20-9
461-96-1
General procedure: A diazonium salt solution was prepared by dissolving 1 mole of 2-bromo-4,6-difluoroaniline hydrobromide in aqueous HCl with 1.1-1.10 moles of NaNO2 at 0°C to 5°C. The solution was then slowly warmed to 15°C, during which time the release of nitrogen was observed. To this solution, 1.5 moles of hypophosphorous acid was added at a temperature below 5°C, followed by a slow warming to 15°C, during which the release of nitrogen was observed. The reaction mixture is stirred for 1 hour, decanted and extracted with a suitable organic solvent to give 1-bromo-3,5-difluorobenzene in 75% molar yield. The target product with purity higher than 99% was obtained by distillation. This method is also applicable to the synthesis of other 1-bromo-3,5-dihalobenzenes.
References
[1] Patent: US5157169, 1992, A
1-Bromo-3,5-difluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Bromo-3,5-difluorobenzene manufacturers
- Product
- 1-Bromo-3,5-difluorobenzene 461-96-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-04
- Product
- 1-Bromo-3,5-difluorobenzene 461-96-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-11
- Product
- 1-bromo-3,5-difluorobenzene 461-96-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09