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1-Bromo-3,5-difluorobenzene

Product Name
1-Bromo-3,5-difluorobenzene
CAS No.
461-96-1
Chemical Name
1-Bromo-3,5-difluorobenzene
Synonyms
3,5-DIFLUOROBROMOBENZENE;DM1Impurity22;uorobromobenzene;5-difluorobenzene;1-Bromo-3,5-difluoro;1-Brom-3,5-difluorbenzol;3,5-difluoro-1-bromobenzene;1-BROMO-3,5-DIFLUOROBENZENE;1-Bromo-3,5-difulorobenzene;1,3-Difluoro-5-bromobenzene
CBNumber
CB3668317
Molecular Formula
C6H3BrF2
Formula Weight
192.99
MOL File
461-96-1.mol
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1-Bromo-3,5-difluorobenzene Property

Melting point:
-27 °C
Boiling point:
140 °C (lit.)
Density 
1.676 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.499(lit.)
Flash point:
112 °F
storage temp. 
Sealed in dry,2-8°C
solubility 
0.238g/l
form 
Liquid
color 
Clear colorless to light yellow
Specific Gravity
1.686
PH
6.6 (0.238g/l, H2O, 20℃)
Water Solubility 
0.238 g/L (20 ºC)
BRN 
1931520
InChIKey
JHLKSIOJYMGSMB-UHFFFAOYSA-N
CAS DataBase Reference
461-96-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N,F,Xi
Risk Statements 
10-22-38-43-48/22-50/53-36/37/38
Safety Statements 
24-36/37-60-61-36-26-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
2
Hazard Note 
Flammable
HazardClass 
3
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
290165
Product name
1-Bromo-3,5-difluorobenzene
Purity
98%
Packaging
10g
Price
$58.66
Updated
2025/07/31
Sigma-Aldrich
Product number
290165
Product name
1-Bromo-3,5-difluorobenzene
Purity
98%
Packaging
100g
Price
$198.59
Updated
2025/07/31
TCI Chemical
Product number
B1764
Product name
1-Bromo-3,5-difluorobenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$60
Updated
2025/07/31
TCI Chemical
Product number
B1764
Product name
1-Bromo-3,5-difluorobenzene
Purity
>98.0%(GC)
Packaging
250g
Price
$241
Updated
2025/07/31
Usbiological
Product number
158405
Product name
1-Bromo-3,5-difluorobenzene
Packaging
25g
Price
$403
Updated
2021/12/16
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1-Bromo-3,5-difluorobenzene Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid.

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

Synthesis

6303-21-5

101471-20-9

461-96-1

General procedure: A diazonium salt solution was prepared by dissolving 1 mole of 2-bromo-4,6-difluoroaniline hydrobromide in aqueous HCl with 1.1-1.10 moles of NaNO2 at 0°C to 5°C. The solution was then slowly warmed to 15°C, during which time the release of nitrogen was observed. To this solution, 1.5 moles of hypophosphorous acid was added at a temperature below 5°C, followed by a slow warming to 15°C, during which the release of nitrogen was observed. The reaction mixture is stirred for 1 hour, decanted and extracted with a suitable organic solvent to give 1-bromo-3,5-difluorobenzene in 75% molar yield. The target product with purity higher than 99% was obtained by distillation. This method is also applicable to the synthesis of other 1-bromo-3,5-dihalobenzenes.

References

[1] Patent: US5157169, 1992, A

1-Bromo-3,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Hydrochloric acid Bromine

Preparation Products

2,6-Difluoro-4-hydroxybenzonitrile 3,5-DIFLUORO-BENZAMIDINE HYDROCHLORIDE
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1-Bromo-3,5-difluorobenzene Suppliers

Americas 1 Belgium 4 Canada 1 China 436 Europe 2 France 4 Germany 6 India 25 Italy 1 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 22 United States 52 Global 565
Elixens
Tel
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Fax
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Country
France
ProdList
146
Advantage
58
Kleos Pharma
Tel
--
Fax
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Email
guedj.gregory@kleos-pharma.com
Country
France
ProdList
298
Advantage
58
Interchim SA
Tel
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Fax
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Email
him@interchim.com
Country
France
ProdList
2725
Advantage
58
Interchim S.A.
Tel
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Fax
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Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from 1-Bromo-3,5-difluorobenzene manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-Bromo-3,5-difluorobenzene 461-96-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-04
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-Bromo-3,5-difluorobenzene 461-96-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-11
airuikechemical co., ltd.
Product
1-bromo-3,5-difluorobenzene 461-96-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09

461-96-1, 1-Bromo-3,5-difluorobenzeneRelated Search:

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  • 461-96-1
  • C6H3BrF2
  • HALIDE
  • Organic Building Blocks
  • Halogenated Hydrocarbons
  • Aryl
  • Building Blocks
  • C6
  • Fluorine series
  • Fluorobenzene
  • Miscellaneous
  • Aryl
  • Halogenated Hydrocarbons
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • bc0001
  • C6