ChemicalBook > CAS DataBase List > 1-Bromo-3,5-difluorobenzene

1-Bromo-3,5-difluorobenzene

Product Name: 1-Bromo-3,5-difluorobenzene
CAS No.: 461-96-1
Chemical Name: 1-Bromo-3,5-difluorobenzene
Synonyms: 3,5-DIFLUOROBROMOBENZENE;DM1Impurity22;uorobromobenzene;5-difluorobenzene;1-Bromo-3,5-difluoro;1-Brom-3,5-difluorbenzol;3,5-difluoro-1-bromobenzene;1-BROMO-3,5-DIFLUOROBENZENE;1-Bromo-3,5-difulorobenzene;1,3-Difluoro-5-bromobenzene
CBNumber: CB3668317
Molecular Formula: C6H3BrF2
Formula Weight: 192.99
MOL File: 461-96-1.mol

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1-Bromo-3,5-difluorobenzene Property

Melting point:: -27 °C
Boiling point:: 140 °C (lit.)
Density: 1.676 g/mL at 25 °C (lit.)
refractive index: n20/D 1.499(lit.)
Flash point:: 112 °F
storage temp.: Sealed in dry,2-8°C
solubility: 0.238g/l
form: Liquid
color: Clear colorless to light yellow
Specific Gravity: 1.686
PH: 6.6 (0.238g/l, H2O, 20℃)
Water Solubility: 0.238 g/L (20 ºC)
BRN: 1931520
InChIKey: JHLKSIOJYMGSMB-UHFFFAOYSA-N
CAS DataBase Reference: 461-96-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,N,F,Xi
Risk Statements: 10-22-38-43-48/22-50/53-36/37/38
Safety Statements: 24-36/37-60-61-36-26-16
RIDADR: UN 1993 3/PG 3
WGK Germany: 2
Hazard Note: Flammable
HazardClass: 3
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290165
Product name: 1-Bromo-3,5-difluorobenzene
Purity: 98%
Packaging: 10g
Price: $58.66
Updated: 2025/07/31

Sigma-Aldrich

Product number: 290165
Product name: 1-Bromo-3,5-difluorobenzene
Purity: 98%
Packaging: 100g
Price: $198.59
Updated: 2025/07/31

TCI Chemical

Product number: B1764
Product name: 1-Bromo-3,5-difluorobenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: B1764
Product name: 1-Bromo-3,5-difluorobenzene
Purity: >98.0%(GC)
Packaging: 250g
Price: $241
Updated: 2025/07/31

Usbiological

Product number: 158405
Product name: 1-Bromo-3,5-difluorobenzene
Packaging: 25g
Price: $403
Updated: 2021/12/16

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1-Bromo-3,5-difluorobenzene Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid.

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

Synthesis

6303-21-5

101471-20-9

461-96-1

General procedure: A diazonium salt solution was prepared by dissolving 1 mole of 2-bromo-4,6-difluoroaniline hydrobromide in aqueous HCl with 1.1-1.10 moles of NaNO2 at 0°C to 5°C. The solution was then slowly warmed to 15°C, during which time the release of nitrogen was observed. To this solution, 1.5 moles of hypophosphorous acid was added at a temperature below 5°C, followed by a slow warming to 15°C, during which the release of nitrogen was observed. The reaction mixture is stirred for 1 hour, decanted and extracted with a suitable organic solvent to give 1-bromo-3,5-difluorobenzene in 75% molar yield. The target product with purity higher than 99% was obtained by distillation. This method is also applicable to the synthesis of other 1-bromo-3,5-dihalobenzenes.

References

[1] Patent: US5157169, 1992, A

1-Bromo-3,5-difluorobenzene Preparation Products And Raw materials

Raw materials

Hydrochloric acid Bromine

Preparation Products

2,6-Difluoro-4-hydroxybenzonitrile 3,5-DIFLUORO-BENZAMIDINE HYDROCHLORIDE

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View Lastest Price from 1-Bromo-3,5-difluorobenzene manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Bromo-3,5-difluorobenzene 461-96-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Bromo-3,5-difluorobenzene 461-96-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-11

airuikechemical co., ltd.

Product: 1-bromo-3,5-difluorobenzene 461-96-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

461-96-1, 1-Bromo-3,5-difluorobenzeneRelated Search:

Decabromodiphenyl Ethane 1,3-Difluorobenzene 3,5-Difluorophenol Transfluthrin 1,2-Difluorobenzene Florfenicol 4-Bromofluorobenzene 1-Bromo-3,5-dichlorobenzene 1,2-Dibromotetrafluorobenzene 1,4-DIBROMOTETRAFLUOROBENZENE 2-BROMO-4,5,6-TRIFLUOROANILINE Bromopentafluorobenzene Bromine 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE 1-Bromo-2,3,5-trifluorobenzene 2-Bromo-4,6-difluoroaniline 1,2-DIBROMO-3,5-DIFLUOROBENZENE 4,4'-DIBROMOOCTAFLUOROBIPHENYL

1-Bromo-3,5-difluorobenzene,99%

1-BROMO-3,5-DIFLUOROBENZENE

3,5-DIFLUOROBROMOBENZENE

1-Bromo-3,5-difluorobenzene,98% [3,5-Difluorobromobenzene]

3,5-difluoro-1-bromobenzene

1-Bromo-3,5-difluorobenzene 98%

1-Bromo-3,5-difluorobenzene98%

1-Brom-3,5-difluorbenzol

3,5-DIFLUOROBROMOBENZENE A.K.A.1-BROMO-3,5-DIFLUOR

3,5-DIFLUORO BROMO BENZENE 461-96-1

1-BroMo-35-difluorobenzene/35-Difluorochlorobenzene

3,5-DifluorobroMobenzene, 97+%

3, 5 - two fluorine broMobenzene

1-Bromo-3,5-difulorobenzene

1-Bromo-3,5-difluoro

3,5-Difluorobromobenzene 98%

5-difluorobenzene

1-BroMo-3,5-difluorobenzene, 99% 10ML

1,3-Difluoro-5-bromobenzene

1-Bromo-3,5-difluorobenzene &gt

uorobromobenzene

Benzene, 1-bromo-3,5-difluoro-

1-Bromo-3,5-difluorobenzene ISO 9001：2015 REACH

DM1Impurity22

1-Bromo-3,5-difluorobenzene, 98%min

461-96-1

C6H3BrF2

HALIDE

Organic Building Blocks

Halogenated Hydrocarbons

Aryl

Building Blocks

Fluorine series

Fluorobenzene

Miscellaneous

Aryl

Halogenated Hydrocarbons

Aromatic Hydrocarbons (substituted) & Derivatives

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