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1-Bromo-2,3-difluorobenzene

Product Name
1-Bromo-2,3-difluorobenzene
CAS No.
38573-88-5
Chemical Name
1-Bromo-2,3-difluorobenzene
Synonyms
2,3-DIFLUOROBROMOBENZENE;2,3-Diflurobromobenzene;2,3-DifluoroBrmorobenzene;1-Bromo-2,3-difL;1-Bromo-2,3-difluoro;Rimegepant Impurity 4;Rimegepant Impurity 33;2,3- twofluorine broMine;1-Bromo-2,3-difluobenzene;1-BROMO-2,3-DIFLUOROBENZENE
CBNumber
CB8236717
Molecular Formula
C6H3BrF2
Formula Weight
192.99
MOL File
38573-88-5.mol
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1-Bromo-2,3-difluorobenzene Property

Boiling point:
234 °C (765 mmHg)
Density 
1.724 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.509(lit.)
Flash point:
142 °F
storage temp. 
2-8°C
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
1.724
InChIKey
RKWWASUTWAFKHA-UHFFFAOYSA-N
CAS DataBase Reference
38573-88-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37/39
RIDADR 
1993
WGK Germany 
3
Hazard Note 
Flammable
HazardClass 
3.2
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B1800
Product name
1-Bromo-2,3-difluorobenzene
Purity
>98.0%(GC)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B1800
Product name
1-Bromo-2,3-difluorobenzene
Purity
>98.0%(GC)
Packaging
5g
Price
$55
Updated
2024/03/01
Alfa Aesar
Product number
B21585
Product name
1-Bromo-2,3-difluorobenzene, 98%
Packaging
1g
Price
$44.65
Updated
2024/03/01
Alfa Aesar
Product number
B21585
Product name
1-Bromo-2,3-difluorobenzene, 98%
Packaging
5g
Price
$132.65
Updated
2024/03/01
TCI Chemical
Product number
B1800
Product name
1-Bromo-2,3-difluorobenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$165
Updated
2024/03/01
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1-Bromo-2,3-difluorobenzene Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to peach liquid

Uses

1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.

Uses

intermediate for liquid crystal and drugs

General Description

Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.

Synthesis

Add 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
Fig The synthetic method of 1-Bromo-2,3-difluorobenzene

storage

Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

1-Bromo-2,3-difluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Bromo-2,3-difluorobenzene Suppliers

Anstar Chemical (Group) Co.,Ltd.
Tel
18053179586
Email
export@anstarchemical.com
Country
China
ProdList
346
Advantage
58
China Synchem Technology Co.,Ltd.
Tel
+86-0552-4929304 +86-18055277008
Fax
+86-552-4928800
Email
sales@cnsynchem.com
Country
China
ProdList
57
Advantage
65
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Shandong Hongyuan Chemical Technology Co., LTD
Tel
13561560789
Email
xinxiaoxiao2008@126.com
Country
China
ProdList
511
Advantage
58
Nanjing Yili Biotechnology Co., Ltd.
Tel
15951679563
Email
2853992905@qq.com
Country
China
ProdList
8136
Advantage
58
Changzhou Zeyuan Pharmaceutical Technology Co., Ltd
Tel
19026388314
Email
2589694173@qq.com
Country
China
ProdList
135
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from 1-Bromo-2,3-difluorobenzene manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
1-Bromo-2,3-difluorobenzene 38573-88-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-19
Kindchem(Nanjing)Co.,Ltd
Product
1-Bromo-2,3-difluorobenzene 38573-88-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100
Release date
2023-12-28
Shaanxi Haibo Biotechnology Co., Ltd
Product
1-Bromo-2,3-difluorobenzene 38573-88-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-28

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