1-Bromo-2,3-difluorobenzene

Product Name: 1-Bromo-2,3-difluorobenzene
CAS No.: 38573-88-5
Chemical Name: 1-Bromo-2,3-difluorobenzene
Synonyms: 2,3-DIFLUOROBROMOBENZENE;2,3-Diflurobromobenzene;2,3-DifluoroBrmorobenzene;1-Bromo-2,3-difL;1-Bromo-2,3-difluoro;Rimegepant Impurity 4;Rimegepant Impurity 33;2,3- twofluorine broMine;2,3-DifluoroBrmorobenzen;1-Bromo-2,3-difluobenzene
CBNumber: CB8236717
Molecular Formula: C6H3BrF2
Formula Weight: 192.99
MOL File: 38573-88-5.mol

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1-Bromo-2,3-difluorobenzene Property

Boiling point:: 234 °C (765 mmHg)
Density: 1.724 g/mL at 25 °C(lit.)
refractive index: n20/D 1.509(lit.)
Flash point:: 142 °F
storage temp.: 2-8°C
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 1.724
InChI: InChI=1S/C6H3BrF2/c7-4-2-1-3-5(8)6(4)9/h1-3H
InChIKey: RKWWASUTWAFKHA-UHFFFAOYSA-N
SMILES: C1(Br)=CC=CC(F)=C1F
CAS DataBase Reference: 38573-88-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
RIDADR: 1993
WGK Germany: 3
Hazard Note: Flammable
HazardClass: 3.2
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B1800
Product name: 1-Bromo-2,3-difluorobenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: B1800
Product name: 1-Bromo-2,3-difluorobenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $55
Updated: 2025/07/31

TCI Chemical

Product number: B1800
Product name: 1-Bromo-2,3-difluorobenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $165
Updated: 2025/07/31

TRC

Product number: B689643
Product name: 1-Bromo-2,3-difluorobenzene
Packaging: 5g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD33473
Product name: 2,3-Difluorobromobenzene
Packaging: 50g
Price: $90
Updated: 2021/12/16

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1-Bromo-2,3-difluorobenzene Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to peach liquid

Uses

1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.

Uses

intermediate for liquid crystal and drugs

General Description

Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.

Synthesis

Add 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
Fig The synthetic method of 1-Bromo-2,3-difluorobenzene

storage

Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

1-Bromo-2,3-difluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Bromo-2,3-difluorobenzene Suppliers

Americas 1 Belgium 1 Canada 1 China 350 Europe 4 France 1 Germany 3 India 18 Italy 1 Japan 3 Russia 1 Sweden 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 41 Global 448

Anstar Chemical (Group) Co.,Ltd.

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Energy Chemical

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View Lastest Price from 1-Bromo-2,3-difluorobenzene manufacturers

Moxin Chemicals

Product: Rimegepant Impurity 38573-88-5
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%+ HPLC
Supply Ability: 1000
Release date: 2025-06-05

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Bromo-2,3-difluorobenzene 38573-88-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Hebei Chuanghai Biotechnology Co,.LTD

Product: 1-Bromo-2,3-difluorobenzene 38573-88-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-19

38573-88-5, 1-Bromo-2,3-difluorobenzeneRelated Search:

4,4'-DIBROMOOCTAFLUOROBIPHENYL 1-Bromo-2,3-difluorobenzene 1,2-Dibromotetrafluorobenzene 1,4-DIBROMOTETRAFLUOROBENZENE 1-BROMO-2,3,6-TRIFLUOROBENZENE 4-BROMO-2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE 1-bromo-2,3,4,6-tetrafluorobenzene 2,3,4-Trifluorobromobenzene 1-Bromo-2,3,5-trifluorobenzene 1-BROMO-2,3,4,5-TETRAFLUOROBENZENE 4-BROMO-2,3,5,6-TETRAFLUOROBENZOIC ACID 1-BROMO-4-CHLORO-2,3,5,6-TETRAFLUOROBENZENE 1,3-DIBROMOTETRAFLUOROBENZENE Bromopentafluorobenzene 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE 4-BROMO-2,5-DIFLUOROBENZENE-1-SULFONYL CHLORIDE 1-Bromo-2,5-difluorobenzene 98%,1-Bromo-2,5-difluorobenzene98%,1-BROMO-2,5-DIFLUOROBENZENE 99.5%,1-BROMO-2,5-DIFLUOROBENZENE,2-BROMO-1,4-DIFLUOROBENZENE 3,5-Difluorochlorobenzene

2,3- twofluorine broMine

1-Bromo-2,3-difluorobenzene 98%

2,3-DIFLUOROBROMOBENZENE

1-BROMO-2,3-DIFLUOROBENZENE

2,3-DifluoroBrmorobenzene

1-Bromo-2,3-Difluorobenzenne

2,3-Difluorobromobenzene 98%

2,3-Difluorobromobenzene98%

1-Bromo-2,3-difluorobenzene,98%

2,3-Diflurobromobenzene

1-Bromo-2,3-difluoro

3-broMo-1,2-difluorobenzene

1-BroMo-2,3-difluorobenzene[2,3-DifluorobroMobenzene]

Benzene,1-bromo-2,3-difluoro-

1-Bromo-2,3-difulorobenzene

1-Bromo-2,3-difluorobenzene &gt

1-Bromo-2,3-difL

1-Bromo-2,3-difluorobenzene ISO 9001：2015 REACH

1-Bromo-2,3-difluobenzene

Rimegepant Impurity 4

Rimegepant Impurity 33

2,3-DifluoroBrmorobenzen

2Chemicalbook,3-DifluoroBrmorobenzene

1-Bromo-2,3-difluorobenzene, 98%min

38573-88-5

38583-88-5

Halogenated Hydrocarbons

Organic Building Blocks

Building Blocks

Aryl

C6

Miscellaneous

Aryl

Halogenated Hydrocarbons

Fluorobenzene Series

Fluorobenzene

Aromatic Halides (substituted)

Other fluorin-contained compounds

Purines

38573-88-5

C6