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1-Bromo-2,3-difluorobenzene

Product Name
1-Bromo-2,3-difluorobenzene
CAS No.
38573-88-5
Chemical Name
1-Bromo-2,3-difluorobenzene
Synonyms
2,3-DIFLUOROBROMOBENZENE;2,3-Diflurobromobenzene;2,3-DifluoroBrmorobenzene;1-Bromo-2,3-difL;1-Bromo-2,3-difluoro;Rimegepant Impurity 4;Rimegepant Impurity 33;2,3- twofluorine broMine;1-Bromo-2,3-difluobenzene;1-BROMO-2,3-DIFLUOROBENZENE
CBNumber
CB8236717
Molecular Formula
C6H3BrF2
Formula Weight
192.99
MOL File
38573-88-5.mol
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1-Bromo-2,3-difluorobenzene Property

Boiling point:
234 °C (765 mmHg)
Density 
1.724 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.509(lit.)
Flash point:
142 °F
storage temp. 
2-8°C
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
1.724
InChIKey
RKWWASUTWAFKHA-UHFFFAOYSA-N
CAS DataBase Reference
38573-88-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37/39
RIDADR 
1993
WGK Germany 
3
Hazard Note 
Flammable
HazardClass 
3.2
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B1800
Product name
1-Bromo-2,3-difluorobenzene
Purity
>98.0%(GC)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B1800
Product name
1-Bromo-2,3-difluorobenzene
Purity
>98.0%(GC)
Packaging
5g
Price
$55
Updated
2024/03/01
Alfa Aesar
Product number
B21585
Product name
1-Bromo-2,3-difluorobenzene, 98%
Packaging
1g
Price
$44.65
Updated
2024/03/01
Alfa Aesar
Product number
B21585
Product name
1-Bromo-2,3-difluorobenzene, 98%
Packaging
5g
Price
$132.65
Updated
2024/03/01
TCI Chemical
Product number
B1800
Product name
1-Bromo-2,3-difluorobenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$165
Updated
2024/03/01
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1-Bromo-2,3-difluorobenzene Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to peach liquid

Uses

1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.

Uses

intermediate for liquid crystal and drugs

General Description

Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.

Synthesis

Add 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
Fig The synthetic method of 1-Bromo-2,3-difluorobenzene

storage

Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

1-Bromo-2,3-difluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Bromo-2,3-difluorobenzene Suppliers

Americas 1 Belgium 1 Canada 1 China 324 Europe 4 France 1 Germany 3 India 17 Italy 1 Japan 3 Russia 1 Sweden 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 41 Global 421
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Fine Corporation
Tel
--
Fax
--
Email
info@fine-c.jp
Country
Japan
ProdList
1427
Advantage
58
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from 1-Bromo-2,3-difluorobenzene manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
1-Bromo-2,3-difluorobenzene 38573-88-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-19
Kindchem(Nanjing)Co.,Ltd
Product
1-Bromo-2,3-difluorobenzene 38573-88-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100
Release date
2023-12-28
Shaanxi Haibo Biotechnology Co., Ltd
Product
1-Bromo-2,3-difluorobenzene 38573-88-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-28

38573-88-5, 1-Bromo-2,3-difluorobenzeneRelated Search:

4,4'-DIBROMOOCTAFLUOROBIPHENYL 1-Bromo-2,3-difluorobenzene 1,2-Dibromotetrafluorobenzene 1,4-DIBROMOTETRAFLUOROBENZENE 1-BROMO-2,3,6-TRIFLUOROBENZENE 4-BROMO-2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE 1-bromo-2,3,4,6-tetrafluorobenzene 2,3,4-Trifluorobromobenzene 1-Bromo-2,3,5-trifluorobenzene 1-BROMO-2,3,4,5-TETRAFLUOROBENZENE 4-BROMO-2,3,5,6-TETRAFLUOROBENZOIC ACID 1-BROMO-4-CHLORO-2,3,5,6-TETRAFLUOROBENZENE 1,3-DIBROMOTETRAFLUOROBENZENE Bromopentafluorobenzene 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE 4-BROMO-2,5-DIFLUOROBENZENE-1-SULFONYL CHLORIDE 1-Bromo-2,5-difluorobenzene 98%,1-Bromo-2,5-difluorobenzene98%,1-BROMO-2,5-DIFLUOROBENZENE 99.5%,1-BROMO-2,5-DIFLUOROBENZENE,2-BROMO-1,4-DIFLUOROBENZENE 3,5-Difluorochlorobenzene

  • 2,3- twofluorine broMine
  • 1-Bromo-2,3-difluorobenzene 98%
  • 2,3-DIFLUOROBROMOBENZENE
  • 1-BROMO-2,3-DIFLUOROBENZENE
  • 2,3-DifluoroBrmorobenzene
  • 1-Bromo-2,3-Difluorobenzenne
  • 2,3-Difluorobromobenzene 98%
  • 2,3-Difluorobromobenzene98%
  • 1-Bromo-2,3-difluorobenzene,98%
  • 2,3-Diflurobromobenzene
  • 1-Bromo-2,3-difluoro
  • 3-broMo-1,2-difluorobenzene
  • 1-BroMo-2,3-difluorobenzene[2,3-DifluorobroMobenzene]
  • Benzene,1-bromo-2,3-difluoro-
  • 1-Bromo-2,3-difulorobenzene
  • 1-Bromo-2,3-difluorobenzene &gt
  • 1-Bromo-2,3-difL
  • 1-Bromo-2,3-difluorobenzene ISO 9001：2015 REACH
  • 1-Bromo-2,3-difluobenzene
  • Rimegepant Impurity 4
  • Rimegepant Impurity 33
  • 38573-88-5
  • 38583-88-5
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • Building Blocks
  • Aryl
  • C6
  • Miscellaneous
  • Aryl
  • C6
  • Halogenated Hydrocarbons
  • Fluorobenzene Series
  • Fluorobenzene
  • Aromatic Halides (substituted)
  • Other fluorin-contained compounds
  • Purines
  • 38573-88-5