ChemicalBook > CAS DataBase List > 4-Bromo-2-fluoroaniline

4-Bromo-2-fluoroaniline

Product Name
4-Bromo-2-fluoroaniline
CAS No.
367-24-8
Chemical Name
4-Bromo-2-fluoroaniline
Synonyms
2-Fluoro-4-Bromoaniline;4-BROMO-2-FLUORO-PHENYLAMINE;4-Bromo-2-fL;AKOS BBS-00003609;Abesili impurity 9;Bromofluoroaniline4;4-Bromo-2-fluoroanil;4-Brom-2-fluoranilin;Fluoro-4-bromoaniline;Vandetanib Impurity 2
CBNumber
CB2765000
Molecular Formula
C6H5BrFN
Formula Weight
190.01
MOL File
367-24-8.mol
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4-Bromo-2-fluoroaniline Property

Melting point:
40-42 °C
Boiling point:
103-108 °C (13 mmHg)
Density 
1.6196 (rough estimate)
refractive index 
1.4710 (estimate)
Flash point:
220 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.50±0.10(Predicted)
form 
Crystalline Mass, Powder, Crystals and/or Chunks
color 
Beige to light brown to brown-gray or gray
BRN 
2081089
Stability:
Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents.
InChI
InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
InChIKey
GZRMNMGWNKSANY-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(Br)C=C1F
CAS DataBase Reference
367-24-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Bromo-2-fluoroaniline(367-24-8)
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Safety

Hazard Codes 
Xi,T,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-37/39-36/37/39-36
RIDADR 
UN2811
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
304220
Product name
4-Bromo-2-fluoroaniline
Purity
98%
Packaging
10g
Price
$48.7
Updated
2025/07/31
Sigma-Aldrich
Product number
304220
Product name
4-Bromo-2-fluoroaniline
Purity
98%
Packaging
50g
Price
$110
Updated
2025/07/31
TCI Chemical
Product number
B1314
Product name
4-Bromo-2-fluoroaniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$72
Updated
2025/07/31
TRC
Product number
B961505
Product name
4-Bromo-2-fluoroaniline
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
B961505
Product name
4-Bromo-2-fluoroaniline
Packaging
10g
Price
$75
Updated
2021/12/16
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4-Bromo-2-fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

4-Bromo-2-fluoroaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

4-Bromo-2-fluoroaniline was used in synthesis of 4-amino-3-fluorophenyl boronic acid. It was also used in chemical modification and synthesis of boronic acid derivatives for ultraviolet-visible titration.

Synthesis


To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 ??C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline.

References

[1] Journal of Organic Chemistry, 2005, vol. 70, # 11, p. 4267 - 4271
[2] Beilstein Journal of Organic Chemistry, 2012, vol. 8, p. 744 - 748
[3] Tetrahedron Letters, 2015, vol. 56, # 41, p. 5646 - 5650
[4] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5852 - 5869
[5] Patent: CN106905168, 2017, A. Location in patent: Paragraph 0026-0029

4-Bromo-2-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

2-Fluoro-4-(methylsulfonyl)aniline
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4-Bromo-2-fluoroaniline Suppliers

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View Lastest Price from 4-Bromo-2-fluoroaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-2-fluoroaniline 367-24-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-2-fluoroaniline 367-24-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
4-Bromo-2-fluoroaniline 367-24-8
Price
US $80.00-20.00/kgkg
Min. Order
1kgkg
Purity
0.99
Supply Ability
10000
Release date
2023-09-26

367-24-8, 4-Bromo-2-fluoroanilineRelated Search:

3-Fluoroaniline 2-Fluoroaniline Diphenylamine 3-Aminobenzotrifluoride 3-Bromoanisole 4-(Trifluoromethoxy)aniline 4-Fluoroaniline Ethyl bromodifluoroacetate 2,4-DIBROMO-6-FLUOROPHENYL ISOTHIOCYANATE 4-Bromo-2,6-difluoroaniline 4-BROMO-2,5-DIFLUORONITROBENZENE 4-BROMO-2-FLUOROPHENYL ISOCYANATE 4'-Bromo-2'-fluoroacetanilide 2,4-DIBROMO-6-FLUOROANILINE Vandetanib 2,6-Dibromo-4-fluoroaniline 2-Bromo-4-fluoroaniline99%,2-Bromo-4-fluoroaniline 99%,2-BROMO-4-FLUOROANILINE 98+%,2-BROMO-4-FLUOROANILINE Bromine

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  • Fluoro-4-bromoaniline
  • 4-Brom-2-fluoranilin
  • 4-Bromo-2-fluoroaniline &gt
  • 4-Bromo-2-fluoroaniline ISO 9001：2015 REACH
  • Vandetanib Impurity 2
  • 4- Bromo 2- Fluoro aniline [ 4-B2FA]
  • Abesili impurity 9
  • 4-Bromo-2-fluoroaniline, 95%
  • 1-ethyl-4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin- 2-one
  • 367-24-8
  • 367-42-8
  • C2 to C6
  • Amines
  • Building Blocks
  • Nitrogen Compounds
  • Organic Building Blocks
  • Trifluoromethoxybenzene Series
  • Anilines, Amides & Amines
  • Bromine Compounds
  • Fluorine Compounds
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Fluorobenzene
  • Fluoro-Aromatics
  • PHARMACEUTICAL INTERMEDIATES
  • Anilines, Aromatic Amines and Nitro Compounds
  • Aniline
  • amine| alkyl Fluorine| alkyl bromide
  • Benzenes