2-Fluoro-4-iodoaniline
- Product Name
- 2-Fluoro-4-iodoaniline
- CAS No.
- 29632-74-4
- Chemical Name
- 2-Fluoro-4-iodoaniline
- Synonyms
- uoro-4-iodoaniL;2-Fluor-4-Iodanilin;2-fluo-4-iodoaniline;2-Fluoro-4-iodoanili;2-fluro-4-iodoaniline;2-FLUORO-4-IODOANILINE;4-iodo-2-fluoroaniline;2-Fluoro-4-idioaniline;4-iodo-o-fluoroaniline;2-FLORO 4-IODO ANILINE
- CBNumber
- CB1281329
- Molecular Formula
- C6H5FIN
- Formula Weight
- 237.01
- MOL File
- 29632-74-4.mol
2-Fluoro-4-iodoaniline Property
- Melting point:
- 55-57 °C (lit.)
- Boiling point:
- 248.6±25.0 °C(Predicted)
- Density
- 2.008±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 2.41±0.10(Predicted)
- form
- Powder
- color
- Off-white to brown
- Water Solubility
- insoluble
- Sensitive
- Light Sensitive
- BRN
- 2081100
- InChIKey
- CUMTUBVTKOYYOU-UHFFFAOYSA-N
- LogP
- 2.680 (est)
- CAS DataBase Reference
- 29632-74-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39-26/37/39
- RIDADR
- PG3
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- IRRITANT-HARMFUL, LIGHT SENSITIVE
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0417
- Product name
- 2-Fluoro-4-iodoaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- F0417
- Product name
- 2-Fluoro-4-iodoaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- F591985
- Product name
- 2-Fluoro-4-iodoaniline
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- F591985
- Product name
- 2-Fluoro-4-iodoaniline
- Packaging
- 50g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- PC3759E
- Product name
- 2-Fluoro-4-iodoaniline
- Purity
- 98%
- Packaging
- 25g
- Price
- $16
- Updated
- 2021/12/16
2-Fluoro-4-iodoaniline Chemical Properties,Usage,Production
Chemical Properties
off-white to brown powder
Uses
2-Fluoro-4-iodoaniline is widely used in the pharmaceutical, chemical and food industries as a fundamental building block to create a variety of important compounds.
General Description
The profiling of iodine-containing metabolites produced by the earthworm Eisenia veneta by exposing it to 2-fluoro-4-iodoaniline was carried out using high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS).
Synthesis
348-54-9
29632-74-4
The general procedure for the synthesis of 2-fluoro-4-iodoaniline from o-fluoroaniline is as follows: o-fluoroaniline (54 g, 486 mmol) was added to an aqueous solution (250 mL) of sodium bicarbonate (41 g, 486 mmol) with vigorous stirring. The suspension was heated to 60 °C in an oil bath and iodine (123 g, 486 mmol) was added in batches. After addition, the dark-colored mixture was continued to be stirred at 60°C for 3 hours. After completion of the reaction, it was cooled to room temperature and dichloromethane (300 mL) was added, followed by saturated sodium bisulfite solution (300 mL). The two-phase system was stirred vigorously for 10 minutes. The mixture was transferred to a 2L separatory funnel and the organic layer was separated. The aqueous layer was further extracted with dichloromethane (3 x 200 mL) and the combined organic phases were washed with brine (200 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under reduced pressure to give a black crystalline solid. Hexane (300 mL) was added to the solid and the mixture was heated to reflux. A hexane solution was poured from the black insoluble syrup. Upon cooling, the product crystallized from hexane as fine yellow needles. Final isolation afforded 65 g (274 mmol) of 2-fluoro-4-iodoaniline as a fine yellow solid in 56% yield with a melting point of 53°C. 1H NMR (400 MHz, CDCl3) δ 8.1 (t, J=8Hz, 1H), 7.4 (d, J=6Hz, 1H), 7.2 (d, J=6Hz, 1H).
References
[1] Journal of the Chemical Society. Perkin Transactions 2, 1999, # 3, p. 481 - 491
[2] Arzneimittel-Forschung/Drug Research, 1984, vol. 34, # 11 A, p. 1612 - 1624
[3] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2870 - 2873
[4] Patent: WO2004/41793, 2004, A1. Location in patent: Page 141
[5] Chemical Communications, 2014, vol. 50, # 17, p. 2136 - 2138
2-Fluoro-4-iodoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-iodoaniline manufacturers
- Product
- 2-Fluoro-4-iodoaniline 29632-74-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-04
- Product
- 2-Fluoro-4-iodoaniline 29632-74-4
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 2-Fluoro-4-iodoaniline 29632-74-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08