2-Fluoro-4-iodoaniline
- Product Name
- 2-Fluoro-4-iodoaniline
- CAS No.
- 29632-74-4
- Chemical Name
- 2-Fluoro-4-iodoaniline
- Synonyms
- uoro-4-iodoaniL;2-Fluor-4-Iodanilin;2-fluo-4-iodoaniline;2-Fluoro-4-iodoanili;2-fluro-4-iodoaniline;2-FLUORO-4-IODOANILINE;4-iodo-2-fluoroaniline;2-Fluoro-4-idioaniline;4-iodo-o-fluoroaniline;2-FLORO 4-IODO ANILINE
- CBNumber
- CB1281329
- Molecular Formula
- C6H5FIN
- Formula Weight
- 237.01
- MOL File
- 29632-74-4.mol
2-Fluoro-4-iodoaniline Property
- Melting point:
- 55-57 °C (lit.)
- Boiling point:
- 248.6±25.0 °C(Predicted)
- Density
- 2.008±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 2.41±0.10(Predicted)
- form
- Powder
- color
- Off-white to brown
- Water Solubility
- insoluble
- Sensitive
- Light Sensitive
- BRN
- 2081100
- InChIKey
- CUMTUBVTKOYYOU-UHFFFAOYSA-N
- LogP
- 2.680 (est)
- CAS DataBase Reference
- 29632-74-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39-26/37/39
- RIDADR
- PG3
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- IRRITANT-HARMFUL, LIGHT SENSITIVE
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0417
- Product name
- 2-Fluoro-4-iodoaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- F0417
- Product name
- 2-Fluoro-4-iodoaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- F591985
- Product name
- 2-Fluoro-4-iodoaniline
- Packaging
- 50g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- F591985
- Product name
- 2-Fluoro-4-iodoaniline
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- J93927
- Product name
- 2-Fluoro-4-iodoaniline
- Packaging
- 100g
- Price
- $55
- Updated
- 2021/12/16
2-Fluoro-4-iodoaniline Chemical Properties,Usage,Production
Chemical Properties
off-white to brown powder
Uses
2-Fluoro-4-iodoaniline is widely used in the pharmaceutical, chemical and food industries as a fundamental building block to create a variety of important compounds.
General Description
The profiling of iodine-containing metabolites produced by the earthworm Eisenia veneta by exposing it to 2-fluoro-4-iodoaniline was carried out using high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS).
Synthesis
348-54-9
29632-74-4
The general procedure for the synthesis of 2-fluoro-4-iodoaniline from o-fluoroaniline is as follows: o-fluoroaniline (54 g, 486 mmol) was added to an aqueous solution (250 mL) of sodium bicarbonate (41 g, 486 mmol) with vigorous stirring. The suspension was heated to 60 °C in an oil bath and iodine (123 g, 486 mmol) was added in batches. After addition, the dark-colored mixture was continued to be stirred at 60°C for 3 hours. After completion of the reaction, it was cooled to room temperature and dichloromethane (300 mL) was added, followed by saturated sodium bisulfite solution (300 mL). The two-phase system was stirred vigorously for 10 minutes. The mixture was transferred to a 2L separatory funnel and the organic layer was separated. The aqueous layer was further extracted with dichloromethane (3 x 200 mL) and the combined organic phases were washed with brine (200 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under reduced pressure to give a black crystalline solid. Hexane (300 mL) was added to the solid and the mixture was heated to reflux. A hexane solution was poured from the black insoluble syrup. Upon cooling, the product crystallized from hexane as fine yellow needles. Final isolation afforded 65 g (274 mmol) of 2-fluoro-4-iodoaniline as a fine yellow solid in 56% yield with a melting point of 53°C. 1H NMR (400 MHz, CDCl3) δ 8.1 (t, J=8Hz, 1H), 7.4 (d, J=6Hz, 1H), 7.2 (d, J=6Hz, 1H).
References
[1] Journal of the Chemical Society. Perkin Transactions 2, 1999, # 3, p. 481 - 491
[2] Arzneimittel-Forschung/Drug Research, 1984, vol. 34, # 11 A, p. 1612 - 1624
[3] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2870 - 2873
[4] Patent: WO2004/41793, 2004, A1. Location in patent: Page 141
[5] Chemical Communications, 2014, vol. 50, # 17, p. 2136 - 2138
2-Fluoro-4-iodoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-4-iodoaniline Suppliers
- Tel
- 0411-88165951 13601035838
- Fax
- 0411-87406949
- marketing@qi-chem.com
- Country
- China
- ProdList
- 160
- Advantage
- 58
- Tel
- 0418-5113999 18740177324
- Fax
- 2851606178
- sales@custchem.com.cn
- Country
- China
- ProdList
- 441
- Advantage
- 58
- Tel
- 15652467323
- sales@inno-chem.com.cn
- Country
- China
- ProdList
- 8293
- Advantage
- 58
- Tel
- +86-024-83607930; 18640359690
- Fax
- 024-83607930
- sales@honghuchem.com
- Country
- China
- ProdList
- 256
- Advantage
- 58
- Tel
- 15250805028
- Fax
- QQ：1048979734
- 1048979734@qq.com
- Country
- China
- ProdList
- 339
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94644
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 15527621225
- 1791901229@qq.com
- Country
- China
- ProdList
- 6945
- Advantage
- 52
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 7471
- Advantage
- 65
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 3997
- Advantage
- 55
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 022-60116533 13207668525
- Fax
- 022-60979672
- saleskc@scipharmacn.com
- Country
- China
- ProdList
- 603
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 0512-65617459 18915409046
- Fax
- 0512-65617459
- sales@sibian-chem.com
- Country
- China
- ProdList
- 1922
- Advantage
- 55
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- 13598610367 0373-7129549
- Fax
- 0373-8369699
- 2468833170@qq.com
- Country
- China
- ProdList
- 932
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 010-010-1234567 17526513758
- 2062435649@qq.com
- Country
- China
- ProdList
- 97
- Advantage
- 49
- Tel
- 18939837085
- Fax
- 2880152141(QQ)
- youchemicals@gmail.com
- Country
- China
- ProdList
- 1839
- Advantage
- 55
View Lastest Price from 2-Fluoro-4-iodoaniline manufacturers
- Product
- 2-Fluoro-4-iodoaniline 29632-74-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-04
- Product
- 2-Fluoro-4-iodoaniline 29632-74-4
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 2-Fluoro-4-iodoaniline 29632-74-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08